Recurrent infections with IgG2 deficiency.

Plebani, Alessandro; Duse, Marzia; Monafò, V.

doi:10.1136/adc.60.7.670

Cited by 16 publications

(7 citation statements)

References 6 publications

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“…Deficiencies of one or more IgO subclasses with normal levels of serum IgG, IgA and IgM have been reported in children with recurrent infections [2,3,11,14,20,22,23,26,28,30] some successfully treated with intravenous immunoglobtdins [4]. Furthermore, IgG2 deficiency is frequently associated with IgA deficiency in ataxia telangiectasia [19] and has also been reported in children with selective IgA deficiency [7,18,27].…”

Section: Introductionmentioning

confidence: 96%

Serum IgG subclass concentrations in healthy subjects at different age: Age normal percentile charts

et al. 1989

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IgG subclass levels were determined in 448 normal children from 6 months to 18 years of age and in 141 healthy adults by radial immunodiffusion using monoclonal antibodies. Age-normal percentile values were calculated for each year of age up to 18 years for IgG1, IgG2, IgG3 and in adults for all four subclasses. The broad spread of IgG4 values in children did not permit calculation of reference values.

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Section: Introductionmentioning

confidence: 96%

Serum IgG subclass concentrations in healthy subjects at different age: Age normal percentile charts

et al. 1989

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“…Bronchiectasis has been occasionally found in patients with IgG subclass deficiencies (IgGSD) (10)(11)(12). These findings could suggest a cause-effect relationship between the two pathologies.…”

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confidence: 99%

IgG subclass deficiencies associated with bronchiectasis.

Gracia¹,

Rodrigo²,

Morell³

et al. 1996

Am J Respir Crit Care Med

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Only a small number of patients with IgG subclass deficiencies (IgGSD) have been observed to have bronchiectasis. Moreover, in the series of patients with bronchiectasis, IgGSD have not been found at any frequency, and the etiology of bronchiectasis remains unclear in 29 to 49% of cases. Serum concentrations of total IgG, IgA, and IgG subclasses as well as pulmonary function were measured in 65 patients (aged: 10 to 74 yr) with bronchiectasis of unknown etiology. An ELISA test was performed to quantify subclasses 1 through 4 using subclass-specific antihuman monoclonal antibodies. IgG subclass estimation in a healthy population with age-stratified normal ranges was derived from 100 adults, 37 children aged between 10 and 12 yr, and 27 adolescents aged between 13 and 16 yr. Serum concentrations of specific IgG antibodies to Haemophilus influenzae type b capsular polysaccharide (Hib-PRP) were also assayed by an ELISA test in 19 of the patients (10 with IgGSD and nine with non-IgGSD) and in 58 healthy individuals before and 3 wk after immunization with Hib-PRP conjugated to meningococcal outer membrane protein complex (OMPC). Thirty-one patients (48%) had low serum concentrations of one or more IgG subclasses (19 IgG2 deficiencies, 2 IgG3 deficiencies, 3 IgG4 deficiencies, and 7 combined subclass deficiencies). All patients showed increased levels of total IgG, IgG1, and IgA, but this rise was significantly higher in patients without IgGSD. Patients with IgGSD showed impaired antibody response to Hib-PRP compared with patients with non-IgGSD and the control group. IgGSD, particularly IgG2 deficiency, are not an unusual cause of bronchiectasis. Therefore, serum levels of IgG subclasses must be assayed whenever other causes of bronchiectasis have been ruled out.

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“…Recent developments on radial immunodi usion using monoclonal antibodies have made possible rather accurate measures on four known subclasses of IgG (assigned IgG 1-4). Deÿciencies of one or more IgG subclasses are associated with recurrent infections in children, see Beck and Heiner [1], Plebani et al [2] and Umetsu et al [3]. As the scope of IgG subclass measurements as a diagnostic tool has increased since the early 1980's, health professionals in various countries have found it useful to establish the percentile ranges for their own populations, see Beard et al [4], Bird et al [5], Plebani et al [6] and Lau et al [7], for example.…”

Section: Introductionmentioning

confidence: 99%

Marginal versus joint Box–Cox transformation with applications to percentile curve construction for IgG subclasses and blood pressures

Shi

2003

Statistics in Medicine

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When age-specific percentile curves are constructed for several correlated variables, the marginal method of handling one variable at a time has typically been used. We address the question, frequently asked by practitioners, of whether we can achieve efficiency gains by joint estimation. We focus on a simple but common method of Box-Cox transformation and assess the statistical impact of a joint transformation to multivariate normality on the percentile curve estimation for correlated variables. We find that there is little gain from the joint transformation for estimating percentiles around the median but a noticeable reduction in variances is possible for estimating extreme percentiles that are usually of main interest in medical and biological applications. Our study is motivated by problems in constructing percentile charts for IgG subclasses of children and for blood pressures in adult populations, both of which are discussed in the paper as examples, and yet our general findings are applicable to a wide range of other problems.

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Recurrent infections with IgG2 deficiency.

Cited by 16 publications

References 6 publications

Serum IgG subclass concentrations in healthy subjects at different age: Age normal percentile charts

Serum IgG subclass concentrations in healthy subjects at different age: Age normal percentile charts

IgG subclass deficiencies associated with bronchiectasis.

Marginal versus joint Box–Cox transformation with applications to percentile curve construction for IgG subclasses and blood pressures

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