Recurrent implantation failure: current update and clinical approach to an ongoing challenge

Laufer, Neri; Simon, Alex

doi:10.1016/j.fertnstert.2012.03.033

Cited by 51 publications

(37 citation statements)

References 5 publications

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“…In conception cycles compared to non-conception cycles, higher number of oocytes retrieved, all available embryos, good-quality embryos, blastocysts, freezing surplus blastocysts, proportion of cycles with embryo transfer of at least one good-quality embryo, and lower dose of gonadotrophins were all related to a higher clinical pregnancy rate which is in consistence with findings of other authors [3, 15–18]. Women who did not get pregnant were older that those who did, but this difference did not reach statistical significance.…”

Section: Discussionsupporting

confidence: 88%

“…The woman’s age, the indication for IVF, ovarian reserve, the treatment protocol employed, uterine pathology, immunological factors, number of embryos transferred, number of available embryos, embryo quality, embryo transfer technique, sperm quality, and luteal phase support were identified as interfering with successful implantation and contributing to recurrent failure. However, reduced endometrium receptivity and low embryo quality are thought to be the most important factors [3]. …”

Section: Introductionmentioning

confidence: 99%

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Endometrial injury, the quality of embryos, and blastocyst transfer are the most important prognostic factors for in vitro fertilization success after previous repeated unsuccessful attempts

Reljič

Knez

Kovač

et al. 2017

J Assist Reprod Genet

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PurposeThe purpose of this study was to find out the most important prognostic factors for achieving a pregnancy after in vitro fertilization (IVF) in women with history of repeated unsuccessful IVF attempts.MethodsWe analyzed factors affecting pregnancy rate in a retrospective study including 429 IVF/ICSI cycles performed in women younger than 40 years with at least three previous consecutive failed IVF/ICSI attempts.ResultsClinical pregnancy was observed in 140/429 (32.6%) cycles. Clinical pregnancy rate (CPR) was significantly higher in cycles with LEI compared to cycles without LEI before embryo transfer (44.4 vs 26.54%, p = 0.007). The CPR was also higher in cycles with day 5 blastocyst- compared with day 3 cleavage-stage embryo transfers (45.51 vs 26.54%, p < 0.001). In multivariate logistic regression model, only transfer of at least one good quality embryo (OR = 4.32, 95% CI 2.41–7.73), local endometrial injury (OR = 1.73, 95% CI 1.02–2.92), and transfer on day 5 (OR = 3.02, 95% CI 1.53–5.94) remained important independent prognostic factors for clinical pregnancy.ConclusionsThese results suggest that hysteroscopy with local injury to the endometrium prior to ovarian stimulation for IVF/ICSI can improve implantation and pregnancy rates in women experiencing recurrent IVF failure. However, large studies are needed to confirm these findings.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Endometrial injury, the quality of embryos, and blastocyst transfer are the most important prognostic factors for in vitro fertilization success after previous repeated unsuccessful attempts

Reljič

Knez

Kovač

et al. 2017

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…RIF is defined as implantation failure following three IVF cycles involving the transfer of a high-grade embryo [1]. Various factors influence successful implantation, including anatomic or endometrial factors, thrombophilia, genetics, and immunologic factors, to name a few [2,3]. However, in terms of a clinical approach, the etiology of RIF remains a complicated challenge [2,4].…”

Section: Introductionmentioning

confidence: 99%

Genetic Variation of Methylenetetrahydrofolate Reductase (MTHFR) and Thymidylate Synthase (TS) Genes Is Associated with Idiopathic Recurrent Implantation Failure

et al. 2016

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The one-carbon metabolism pathway disorder was important role in successful pregnancy. The MTHFR and TS protein were crucial factor in one-carbon metabolism. To investigate the association between recurrent implantation failure (RIF) and enzymes in the one-carbon metabolism pathway. A total of 120 women diagnosed with RIF and 125 control subjects were genotyped for MTHFR 677C>T, 1298A>C, TSER 2R/3R and TS 1494del/ins by a polymerase chain reaction-restriction fragment length polymorphism assay. According to the gene-gene combination analysis, the MTHFR 677/MTHFR 1298 (TT/AA) and MTHFR 677/TS 1494 (TT/6bp6bp) genetic combinations were associated with relatively higher risks [adjusted odds ratio (AOR), 2.764; 95% CI, 1.065–7.174; P = 0.037 and AOR, 3.186; 95% CI, 1.241–8.178; P = 0.016] in RIF patients compared to the CC/AA (MTHFR 677/MTHFR 1298) and TT/6bp6bp (MTHFR 677/TS 1494) combinations, respectively. The results suggested that the combined MTHFR 677/MTHFR 1298 genotype might be associated with increased risk of RIF. To the best of our knowledge, this study is the first to elucidate the potential association of MTHFR, TS and TSER polymorphisms with RIF risk in Korean patients.

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“…Still there is no universally accepted definition for RIF, but most fertility specialists agree that it refers to the failure to achieve a clinical pregnancy after transfer of at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman under the age of 40 years [13,14,15,16,39] .…”

Section: Results Of the Study In The Context Of Other Observationsmentioning

confidence: 99%

PRP in recurrent implantation failure, hope or hype? A Prospective randomized controlled study

Rageh

Barakat

Ahmed

et al. 2020

Evidence Based Women's Health Journal

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Introduction:The endometrial function and endometrial receptivity have been accepted to be major limiting factors in the establishment of pregnancy. In spite of improved almost all aspects of IVF: ovarian stimulation, embryo culture and transfer, the pregnancy rates still not satisfactory. The bottleneck is the process of implantation. Recurrent implantation failure (RIF) is one of the nightmares in reproductive medicine and despite several strategies that have been described for management; there is no universal agreement yet. Recently, intrauterine infusion of platelet-rich plasma (PRP) is described to promote endometrial growth and receptivity, PRP has been investigated as a therapeutic approach for several medical disorders in dermatology and rheumatology, but its use in IVF is still limited. Aim: To evaluate the effectiveness of intrauterine perfusion of autologous platelet-rich plasma in improvement of pregnancy rate in RIF patients. Design: Prospective randomized controlled study. Patients and Methods: After ethical committee approval was obtained, 150 infertile women with history of RIF gave their consent to be included in this study, with age below 40 yrs, body mass index (BMI) below 30 kg/m2. They were divided into 2 comparable groups ; all participants underwent antagonist protocol. In the study group, intrauterine infusion of (PRP) was performed 48 hrs before blastocyst transfer, pregnancy tests were done 12 days after ET. Results: Out of 75 participants in each group, 32 got pregnant (43%) in the study group, compared to 11 pregnant participants (15%) in control group. Conclusion: According to our study, PRP significantly improved the pregnancy rate and may be a new hope in RIF patients.

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Recurrent implantation failure: current update and clinical approach to an ongoing challenge

Cited by 51 publications

References 5 publications

Endometrial injury, the quality of embryos, and blastocyst transfer are the most important prognostic factors for in vitro fertilization success after previous repeated unsuccessful attempts

Endometrial injury, the quality of embryos, and blastocyst transfer are the most important prognostic factors for in vitro fertilization success after previous repeated unsuccessful attempts

Genetic Variation of Methylenetetrahydrofolate Reductase (MTHFR) and Thymidylate Synthase (TS) Genes Is Associated with Idiopathic Recurrent Implantation Failure

PRP in recurrent implantation failure, hope or hype? A Prospective randomized controlled study

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