Recurrent hypokalemic paralysis in hypothyroidism

Singh, Jitendra; Dinkar, Anju; Kumar, Nilesh; Krishna, K. R.

doi:10.1016/j.amjms.2023.01.009

Cited by 2 publications

(6 citation statements)

References 26 publications

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Section: Introductionmentioning

confidence: 99%

“…(3) peripheral nerve or nerve root dysfunction; and (4) muscular disease-periodic paralysis. [2][3][4] Infectious, autoimmune, and toxic causes are the most prevalently seen causes of this condition, which can be fatal in some cases. Therefore, the reason should be identified, and an appropriate diagnosis should be initiated as soon as possible.…”

Section: Introductionmentioning

confidence: 99%

“…One of the relatively prevalent neuromuscular complaints among patients presenting to the emergency rooms are rapidly progressive neuromuscular paralysis, which can reach its maximum level in less than days or weeks 1 . A wide range of etiologies can cause this condition, and differentiating them is not always straightforward, but differential diagnoses can be limited by considering their specific features 2 . These etiologies are generally categorized into four main groups, including: (1) anterior horn cell pathologies; (2) abnormal neuromuscular junction function; (3) peripheral nerve or nerve root dysfunction; and (4) muscular disease—periodic paralysis 2–4 .…”

Section: Introductionmentioning

confidence: 99%

“… 1 A wide range of etiologies can cause this condition, and differentiating them is not always straightforward, but differential diagnoses can be limited by considering their specific features. 2 These etiologies are generally categorized into four main groups, including: (1) anterior horn cell pathologies; (2) abnormal neuromuscular junction function; (3) peripheral nerve or nerve root dysfunction; and (4) muscular disease—periodic paralysis. 2 , 3 , 4 Infectious, autoimmune, and toxic causes are the most prevalently seen causes of this condition, which can be fatal in some cases.…”

Section: Introductionmentioning

confidence: 99%

“… 2 These etiologies are generally categorized into four main groups, including: (1) anterior horn cell pathologies; (2) abnormal neuromuscular junction function; (3) peripheral nerve or nerve root dysfunction; and (4) muscular disease—periodic paralysis. 2 , 3 , 4 Infectious, autoimmune, and toxic causes are the most prevalently seen causes of this condition, which can be fatal in some cases. Therefore, the reason should be identified, and an appropriate diagnosis should be initiated as soon as possible.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Hypokalemic paralysis following intramuscular betamethasone injection: A case report and review of literature

Ebrahimi,

Taheri,

Mousavinejad

et al. 2024

Clinical Case Reports

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Key Clinical MessageAcute neuromuscular paralysis is a relatively common condition in emergency rooms (ERs). They can be caused by several reasons, including adverse drug reactions. Betamethasone is a glucocorticoid commonly used for various conditions, such as allergic conditions. One of the rare but known side effects of glucocorticoids is hypokalemia. Rare cases of hypokalemia following high‐ and low‐dose glucocorticoid injections have been reported. This study presents the history of a young, healthy male without significant past medical history who presented with an inability to stand and walk due to four‐limb paralysis (more prominent in the lower limbs) following an intramuscular injection of a 4 mg betamethasone, which was prescribed for the treatment of allergic rhinitis. The patient was stabilized with an intravascular injection of potassium chloride diluted in 1000 mL of normal saline and monitored for 24 h, ruling out any other endocrine condition. Hypokalemia and its severe form are defined as the serum level of lower than 3.5 and 2.5 mEq/Lit, respectively. One of the etiologies of drug‐induced hypokalemic paralysis is systemic glucocorticoid administration. In severe cases, it can cause quadriplegia and other neuromuscular, respiratory, and cardiac complications. Therefore, it is an urgent condition that should be managed carefully. Pregnant women who are receiving these medications are a specific group at risk of hypokalemic paralysis. There are several safer treatments for seasonal allergic rhinitis compared to systemic glucocorticoids, which should be considered by physicians. Moreover, paralysis in patients receiving these medications should be approached attentively since it might be caused by hypokalemia, which can be life threatening if not treated. It is advisable that the blood level of electrolytes, especially potassium, be checked for patients who present with paralysis or weakness after glucocorticoid injections.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%