Recurrent Hypokalemic Muscle Weakness as an Initial Manifestation of Wilson’s Disease

Nakazawa, R.; Kaneko, Mai; Hoshi, Hisakazu; Kim, T.; Nakamura, Mieko; Azuma, Nakanobu; Suzuki, Mikiya; Jin, Dong Kyu; Kohsaka, Takao; Koo, Ja Wook; Ha, Il Soo; Cheong, Hae Il; Choi, Yong

doi:10.1159/000189114

Cited by 25 publications

(7 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The creatine kinase level in this patient was high (initially 704 IU/l and increased to 1262 IU/L subsequently, reference range: 60-300) probably due to rhabdomyolysis associated with hypokalemia and RTA [5,7], although this did not result in acute kidney injury (AKI).…”

Section: Case Presentationmentioning

confidence: 85%

See 1 more Smart Citation

Hypokalemic paralysis associated with cystic disease of the kidney: case report

et al. 2011

View full text Add to dashboard Cite

BackgroundSevere hypokalemia is known to cause muscle paralysis, and renal tubular acidosis is a recognized cause. Cystic disease of the kidney is associated with severe hypokalemia.Case presentationWe report a 33-year-old male patient who presented with generalized limb weakness caused by severe hypokalemia due to renal tubular acidosis, who was found to have renal medullary cysts.ConclusionThe association of cystic renal disease with hypokalemia, and the possible pathophysiological basis of the development of renal cysts in patients with severe hypokalemia, are discussed.

show abstract

Section: Case Presentationmentioning

confidence: 85%

“…The possibility of Wilsons disease was considered as it may also present as renal tubular acidosis[7]. However, ophthalmological assessment excluded Kaiser-Fleisher (KF) rings in this patient.…”

Section: Case Presentationmentioning

confidence: 99%

Hypokalemic paralysis associated with cystic disease of the kidney: case report

et al. 2011

View full text Add to dashboard Cite

show abstract

“…As copper can be accumulated in different organs and systems, WD has been associated with arthropathy[ 22 ], recurrent muscle weakness due to hypokalaemia[ 23 ], cardiomyopathy[ 24 ], symptomatic urolithiasis[ 25 ], pancreatitis[ 26 ], cases of hypoparathyroidism[ 27 ], and infertility[ 28 , 29 ].…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Wilson's disease: Revisiting an old friend

Lucena-Valera¹,

Perez-Palacios²,

Muñoz³

et al. 2021

WJH

View full text Add to dashboard Cite

Wilson's disease (WD) is a rare condition caused by copper accumulation primarily in the liver and secondly in other organs, such as the central nervous system. It is a hereditary autosomal recessive disease caused by a deficiency in the ATP7B transporter. This protein facilitates the incorporation of copper into ceruloplasmin. More than 800 mutations associated with WD have been described. The onset of the disease frequently includes manifestations related to the liver (as chronic liver disease or acute liver failure) and neurological symptoms, although it can sometimes be asymptomatic. Despite it being more frequent in young people, WD has been described in all life stages. Due to its fatal prognosis, WD should be suspected in all patients with unexplained biochemical liver abnormalities or neurological or psychiatric symptoms. The diagnosis is established with a combination of clinical signs and tests, including the measurement of ceruloplasmin, urinary copper excretion, copper quantification in liver biopsy, or genetic assessment. The pharmacological therapies include chelating drugs, such as D-penicillamine or trientine, and zinc salts, which are able to change the natural history of the disease, increasing the survival of these patients. In some cases of end-stage liver disease or acute liver failure, liver transplantation must be an option to increase survival. In this narrative review, we offer an overview of WD, focusing on the importance of clinical suspicion, the correct diagnosis, and treatment.

show abstract

“…[ 7 ] The clinical presentation of RTA in Wilson's disease includes a number of facets which may involve hypercalcuria, nephrocalcinosis, urolithiasis, hypokalemic periodic paralysis, and a low bone mass. [ 12 ] Surprisingly, urolithiasis has been reported in about one sixth of patients with Wilson's disease and at times, renal colic may be the sole presenting feature. [ 13 ] Indeed, undiagnosed nephrocalcinosis may progress to end stage renal disease.…”

Section: E Ndocrine M Anifestations Of mentioning

confidence: 99%

Wilson′s disease: An endocrine revelation

Kapoor

Shetty

Nicolaï

et al. 2014

Indian J Endocr Metab

View full text Add to dashboard Cite

Wilson's disease is an inherited disorder of copper metabolism. The affected patients, who otherwise have a near normal life span, may often suffer from some potentially treatable and under recognized endocrine disorders that may hinder their quality of life. We explored previously published literature on the various endocrine aspects of this disease with their probable underlying mechanisms, highlighting the universal need of research in this area.

show abstract

Recurrent Hypokalemic Muscle Weakness as an Initial Manifestation of Wilson’s Disease

Cited by 25 publications

References 11 publications

Hypokalemic paralysis associated with cystic disease of the kidney: case report

Hypokalemic paralysis associated with cystic disease of the kidney: case report

Wilson's disease: Revisiting an old friend

Wilson′s disease: An endocrine revelation

Contact Info

Product

Resources

About