Recurrent Hyperglycemia Associated With Sepsis in a Neonate

James, Thomas; Blessa, Marta; Boggs, Thomas R.

doi:10.1001/archpedi.1979.02130060085020

Cited by 7 publications

(3 citation statements)

References 13 publications

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“…In contrast, most infected infants who remain normoglycemic have gram-positive organisms and mixed flora [20]. On the other hand, hyperglycemia and simultaneous abnormally low insulin levels, indicating inadequate insulin response, have been reported in an infant suffering E coli sepsis [21]. To our knowledge, glucose levels in premature infants with NEC have not been studied.…”

Section: Discussionmentioning

confidence: 95%

Laboratory parameters predictive of developing necrotizing enterocolitis in infants born before 33 weeks of gestation

Hällström

Koivisto

Janas

et al. 2006

Journal of Pediatric Surgery

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Section: Discussionmentioning

confidence: 95%

Laboratory parameters predictive of developing necrotizing enterocolitis in infants born before 33 weeks of gestation

Hällström

Koivisto

Janas

et al. 2006

Journal of Pediatric Surgery

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“…[14] Stress hyperglycemia has been described in children with cystic fibrosis, sepsis, near drowning, falls, traumatic brain injury and following cardiac surgery. [15161718192021]…”

Section: Introductionmentioning

confidence: 99%

Hyperglycemia in critically ill children

Patki¹,

Chougule²

2014

Indian Journal of Critical Care Medicine

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Objectives:To determine the incidence and study association of hyperglycemia with outcome of critically ill children.Setting and Design:This was a prospective observational study conducted in eight bedded pediatric intensive care unit (PICU) of a tertiary care hospital.Materials and Methods:One hundred and one critically ill non-diabetic children between ages of 1 month to 16 years were studied from the day of admission till discharge or death. Serial blood sugars were determined first at admission, thereafter every 12 hourly in all children. Blood glucose level above 126 mg/dl (>7 mmol/dl) was considered as hyperglycemia. Children with hyperglycemia were followed 6 hourly till blood glucose fell below 126 mg/dl. Hyper and non-hyperglycemic children were compared with respect to length of stay, mechanical ventilation, use of inotrops and final outcome. Survivors and non-survivors were compared in relation to admission blood glucose, peak blood glucose level and duration of hyperglycemia.Results:Seventy (69.3%) children had hyperglycemia. Requirement of ventilation [(23) 32.9% vs.(3) 9.7%], requirement of inotropic support [(27) 38.6% vs.(5) 16.1%], Mean length of stay in PICU (7.91 ± 5.01 vs. 5.58 ± 1.95 days) and mortality (28.6% vs. 3.2%) among hyperglycemic children was significantly higher (P < 0.05) than that of non-hyperglycemic. Logistic regression analysis showed Peak blood glucose level and duration of hyperglycemia has independent association with increased risk of death.Conclusion:Incidence of hyperglycemia is high in critically ill children and it is associated with high morbidity and mortality.

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“…Stress hyperglycemia has been described in children with cystic fibrosis, sepsis, near drowning, falls, traumatic brain injury, and following cardiac surgery (3)(4)(5)(6)(7)(8)(9)(10). In a retrospective study of patients admitted to a pediatric ICU (PICU), hyperglycemia and hypoglycemia were common and were associated with poorer outcomes (11).…”

mentioning

confidence: 99%