Recurrent Hematuria in 4 White Patients with Sickle Cell Trait

Oksenhendler, Éric; Bourbigot, B.; Desbazeille, François; Droz, Dominique; Choquenet, C; Girot, Robert; Jungers, Paul

doi:10.1016/s0022-5347(17)50097-x

Cited by 16 publications

(4 citation statements)

References 22 publications

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“…Despite autopsy, microscopic findings, and hemoglobin electrophoresis, the family physician had great difficulty believing the results. Complications of SCT including splenic syndrome in Caucasians have been described in the literature primarily due to exposure to altitude (50–55). Interestingly, the deceased reportedly previously experienced abdominal pain after working out in the gym; one can only speculate that SCT‐related splenic syndrome may have been the cause.…”

Section: Discussionmentioning

confidence: 99%

Sickle Cell Trait-Associated Deaths: A Case Series with a Review of the Literature*,†

Thogmartin

Wilson

Palma

et al. 2011

Journal of Forensic Sciences

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This study presents a series of 16 carriers of hemoglobin S (HbS) who died during various circumstances. Many of the cases were associated with mild to moderate exertion. The onset and/or duration of symptoms varied from a few minutes to several hours with many displaying a prolonged lucid interval with stable vital signs. Despite seeking medical treatment, sickle cell trait-related micro-occlusive crisis was never considered in the differential diagnosis. Several cases were associated with sudden death. In those deaths which were delayed, high anion gap and uncompensated metabolic acidosis were typical and were not heat related. Also characteristic were large increases in creatine kinase, alanine aminotransferase, and aspartate aminotransferase along with myoglobinemia. Although the antemortem diagnosis of rhabdomyolysis was made, the underlying cause was never deduced by the clinicians. The sickling found at autopsy is not always a postmortem artifact, and in the right circumstances can be diagnostic.

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Section: Discussionmentioning

confidence: 99%

Sickle Cell Trait-Associated Deaths: A Case Series with a Review of the Literature*,†

Thogmartin

Wilson

Palma

et al. 2011

Journal of Forensic Sciences

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“…Therefore, it is not surprising that there are pathologic findings from the chronic sickling process, including hyposthenuria, infarction, and hematuria from papillary necrosis. Both individuals with sickle cell disease and SCT can develop gross and painless hematuria, which is usually unilateral and originates commonly in the left kidney, probably from increased venous pressure in the longer left renal vein . Additionally, African‐Americans with SCT have two times the prevalence of end‐stage renal disease (ESRD) than individuals without this trait (15% prevalence compared to 7%, respectively) .…”

Section: Introductionmentioning

confidence: 99%

Renal medullary carcinoma and sickle cell trait: A systematic review

Álvarez

Rodríguez

Jordan

et al. 2015

Pediatr Blood Cancer

105

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Sickle cell trait (SCT) carries a small risk of renal medullary carcinoma (RMC). We conducted a systematic literature review and reported new four RMC cases (total N = 217). Eighty eight percent had SCT and 8% had sickle cell disease; 50% were children. Males had 2.4× risk than females. Isolated hematuria or in combination with abdominal or flank pain was the presenting sign in 66% cases. Tumor-related mortality was 95%. Four non-metastatic patients were long-term disease-free survivors. Although risk appears to be very low, individuals with SCT should be informed about the low risk of RMC with the hope of early diagnosis. Hematuria should prompt immediate investigation.

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“…It is associated with hematuria, but it is not always accompanied by haematuria. The haematuria of the SCA may be of any age and is more common in SCA carriers [16]. In the study of 73 SCA, hematuria was detected in 7 patients [11].…”

Section: Discussionmentioning

confidence: 99%

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2017

J Ann Eu Med

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Recurrent Hematuria in 4 White Patients with Sickle Cell Trait

Cited by 16 publications

References 22 publications

Sickle Cell Trait-Associated Deaths: A Case Series with a Review of the Literature*,†

Sickle Cell Trait-Associated Deaths: A Case Series with a Review of the Literature*,†

Renal medullary carcinoma and sickle cell trait: A systematic review

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