Recurrent HELLP Syndrome at 22 Weeks of Gestation

Kaščák, Peter; Paskala, Milos; Péter, Antal; Gajdosik, Radovan

doi:10.1155/2017/9845637

Cited by 3 publications

(8 citation statements)

References 15 publications

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“…She was discharged eight days after the procedure, continuing antihypertensive and LMWH therapy and receiving treatment to cease lactation, as well as a referral for a thrombophilia screening. 7 In a subsequent occurrence in 2013, at 40 years old and pregnant for the second time, the same patient presented at 21 weeks and 2 days of gestation, reporting epigastric pain, headache, chills, and continuous vomiting. She had a history of a previous termination in 2009 due to severe preeclampsia and HELLP syndrome, which was confirmed to be associated with a heterozygous factor V Leiden mutation.…”

Section: Resultsmentioning

confidence: 95%

“…6 In Kascak et al documented case, we report a rare recurrence of preeclampsia and HELLP syndrome, both occurrences manifesting at an early gestational age. 7 Previous investigations illustrate the rarity of HELLP syndrome before 28 weeks of gestation, with no instances reported in a study analyzing 34 pregnancies in Ostrava, Czech Republic. 13 Another tenyear analysis in a tertiary maternity center in the Netherlands documented 26 cases of preeclampsia occurring before 24 weeks, wherein 65% experienced severe maternal morbidity, including HELLP syndrome, eclampsia, pulmonary edema, and a single maternal death.…”

Section: Discussionmentioning

confidence: 99%

“…Her situation aligns with tbe case and that of a 41year-old primigravida experiencing severe HELLP syndrome at 17 weeks of gestation. 7 The management of HELLP syndrome aims to prevent severe maternal morbidity and mortality. In instances with a nonviable fetus, vaginal termination of pregnancy is preferred, but various factors, including cervix score, disease progression speed, symptom severity, and feasibility of early delivery, must be considered.…”

Section: Discussionmentioning

confidence: 99%

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Maternal and Fetal Outcomes in Hellp Syndrome at 23 Weeks Gestation: Systematic Review

Aldela Paramerta

2023

JARMHS

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Introduction: Hypertensive disorders, affecting 5-10 of pregnancies, are a leading cause of maternal and perinatal mortality. Preeclampsia-eclampsia, a syndrome contributing to significant global deaths, demands prompt identification and management, particularly in resource-limited settings. Detecting and addressing early and late-onset preeclampsia are crucial for maternal and neonatal well-being. HELLP syndrome, a severe complication of preeclampsia, presents diverse symptoms and risks, with a maternal mortality rate as high as 24 Understanding its outcomes in pregnancies before 23 weeks is essential to guide better management strategies for improved maternal and neonatal health in such critical cases. Methods: The researchers in this study followed the 2020 Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines to ensure that their work met the required standards. This was done to ensure the precision and reliability of the conclusions derived from the research. Result: Our search produced 15 results. After looking at the titles and summaries, we found 6 papers that fit our criteria. At first, we excluded one articles because they were written in a review style. But after reading the full papers carefully, we included four papers in our final analysis. These papers included a retrospective observational study and several case reports. Conclusion: Occurrences of HELLP syndrome without associated hypertensive disorders and recurrent intrahepatic ruptures at extremely premature gestational ages are rare but pose significant risks to mothers and newborns. Swift diagnosis, pregnancy termination, and continuous monitoring are crucial to address early-onset HELLP syndrome, emphasizing the need for immediate attention and prompt management.

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Section: Resultsmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Maternal and Fetal Outcomes in Hellp Syndrome at 23 Weeks Gestation: Systematic Review

Aldela Paramerta

2023

JARMHS

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“…Even 10% of HELLP syndrome can occur below 27 weeks of gestational age. 19 This will be a concern since delivery is still the best management for HELLP syndrome. 20 SDP and DBP in preeclampsia and HELLP syndrome were different significantly (p<0.05) with median SDP was higher in HELLP and similar median DBP for both groups.…”

Section: Discussionmentioning

confidence: 99%

Maternal Characteristics, Pregnancy, and Neonatal Outome in Preeclampsia and HELLP Syndrome: a Comparative Study

Sungkar¹,

Irwinda²,

Surya³

et al. 2021

ejki

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HELLP syndrome is a complication in pregnancy which may increase maternal morbidity and mortality risk. This study aims to compare maternal characteristics, pregnancy and neonatal outcome between preeclampsia and HELLP syndrome. All preeclampsia without or with severe features and HELLP syndrome using ACOG criteria coming to dr. Cipto Mangunkusumo Hospital from January 2015 to December 2017 were recruited into this cross-sectional study. Demographic, clinical, laboratories parameters, and neonatal outcomes were compared between HELLP and preeclampsia patients. The SPSS 20 for Windows was used for all analyses. There were 676 deliveries which was complicated by preeclampsia without or with severe features and 113 patients with HELLP syndrome. Gestational age, history of hypertension systolic and diastolic blood pressure, hemoglobin, hematocrit, urea, creatinine, uric acid, and albumin are different significantly between HELLP and preeclampsia patients. History of hypertension in previous pregnancy is considered as a significant risk factor for HELLP syndrome (p=0.001); RR 2.33 (95% CI 1.41–3.9). Based on data of gestational age at delivery which lower in HELLP syndrome, it showed lower median birth weight in HELLP syndrome (1442.5 g) compared with preeclampsia (1442.5 g vs 2400 g, p=; 95%CI There is significant difference in gestational age at delivery, nullipara, blood pressure, and laboratory findings (urea, creatinine, uric acid, albumin) between preeclampsia and HELLP syndrome group. History of hypertension in previous pregnancy is a significant risk factor for HELLP syndrome. Regarding neonatal outcome, baby born from HELLP syndrome has lower median birth weight. Keywords: HELLP syndrome, preeclampsia, risk factor, neonatal outcome. Karakteristik Maternal, Luaran Kehamilan, dan Neonatal pada Preeklamsia dan Sindrom HELLP: Studi Komparatif Abstrak Sindrom HELLP merupakan komplikasi kehamilan yang meningkatkan morbiditas dan mortalitas maternal. Studi ini bertujuan untuk mengetahui perbedaan karakteristik antara sindrom HELLP dan preeklamsia serta luaran neonatus. Studi potong lintang ini melibatkan seluruh pasien preeklamsia dengan atau tanpa perburukan dan sindrom HELLP berdasarkan kriteria ACOG yang datang ke RS dr. Cipto Mangunkusumo pada bulan Januari 2015 sampai Desember 2017. Analisis bivariat digunakan untuk mengetahui hubungan karakteristik demografi, klinis, laboratorium antara pasien HELLP dan preeklamsia sedangkan analisis multivariat untuk mengetahui karakteristik yang memengaruhi sindrom HELLP. Data dianalisis menggunakan SPSS 20. Terdapat 676 persalinan pada kelompok preeklamsia dengan atau tanpa perburukan dan 113 pasien dengan sindrom HELLP. Usia kehamilan, tekanan darah sistolik dan diastolik, hemoglobin, hematokrit, ureum, kreatinin, asam urat, dan albumin berbeda bermakna antara pasien sindrom HELLP dan preeklamsia. Riwayat hipertensi pada kehamilan sebelumnya dianggap sebagai faktor risiko terhadap sindrom HELLP (p=0,001); RR 2,33 (IK 95% 1,41-3,9). Berdasarkan usia kehamilan saat persalinan yang lebih awal dan bayi lahir lebih rendah pada sindrom HELLP (1442,5 g) dibandingkan preeklamsia (2400 g). Terdapat perbedaan bermakna pada usia kehamilan saat persalinan, tekanan darah, dan parameter laboratorium (ureum, kreatinin, asam urat, albumin) antara kelompok preeklamsia dan sindrom HELLP. Berdasarkan luaran neonatus, bayi dari sindrom HELLP lebih rendah berat lahirnya. Kata kunci: sindrom HELLP, preeklamsia, faktor risiko, luaran neonatus

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“…In both cases, caesarean section was perfomed. Fetuses weighed 280 g and 455 g (16). In another case reports, authors wrote about complication of HELLP syndrome.…”

Section: Discussionmentioning

confidence: 99%

Active surveillance of incidence and risk factors of hemolysis, elevated liver enzymes and low platelets syndrome in Slovakia

M¹,

Krištúfková²,

Némethová³

et al. 2019

BLL

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OBJECTIVE: Hemolysis, Elevated Liver Enzymes, Low Platelets syndrome (HELLP syndrome) is one of the actively haunted maternal morbidity through Slovak Obstetric Survey System (SOSS), the organisation for surveillance of severe maternal morbidity and mortality in Slovakia. METHODS: The questionaires were sent in 55 Obstetric Units in Slovakia. The analyzed and here presented data had been collected cases those happened in the period from 1.1.2012 till 31.12.2014. Controls were women from SR during observed years, who delivered without HELLP syndrome. RESULTS: The return rate of questionnaires was 89.67 %, thus covering 146 972 deliveries during the study period in Slovakia. The exact incidence of HELLP syndrome was 0.63/1000 deliveries (CI 95 % 0.51-0.78). Risk factors were age > 30 (OR = 1.63), nuliparous (OR = 2.96), pregnancy after assisted reproduction technology (OR = 8.29) and multiple pregnancy OR = 9.19). The mean gestation age at delivery was 33.8th weeks. Vaginal delivery was by 10 (10.8 %) patients with HELLP syndrome and in the 83 (89.2 %) patients pregnancy was terminated with acute caesarean section. There were reported 45 050 cases (30.7 %) of the caesarean section in the control group throughout the study period. CONCLUSION: The older age, nulliparity, multiple pregnancy and pregnancy after assisted reproduction techniques was identifi ed as a signifi cant risk factors of HELLP syndrome (Tab. 5, Fig. 1, Ref.

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Recurrent HELLP Syndrome at 22 Weeks of Gestation

Cited by 3 publications

References 15 publications

Maternal and Fetal Outcomes in Hellp Syndrome at 23 Weeks Gestation: Systematic Review

Maternal and Fetal Outcomes in Hellp Syndrome at 23 Weeks Gestation: Systematic Review

Maternal Characteristics, Pregnancy, and Neonatal Outome in Preeclampsia and HELLP Syndrome: a Comparative Study

Active surveillance of incidence and risk factors of hemolysis, elevated liver enzymes and low platelets syndrome in Slovakia

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