Recurrent Headache and MRI Findings in Systemic Lupus Erythematosus

Headache in Systemic Lupus Erythematosus vs Multiple Sclerosis: A Prospective Comparative Study

“…Although migraine is related with small brain lesions, 29 imaging studies also failed to detect any association between brain lesions and all headache types in SLE patients 30,31 . Moreover, within SLE migraineurs no relation between brain MRI lesions and anti‐phospholipid antibodies or abnormal coagulation parameters could be established 31 . Thus, there is no evidence that brain lesions are related with any headache type in the context of SLE.…”

“…However, recent controlled studies intended to detect cognitive impairment in SLE patients with chronic headaches, including migraines, that would possibly indicate cortical damage failed to reveal an association 28 . Although migraine is related with small brain lesions, 29 imaging studies also failed to detect any association between brain lesions and all headache types in SLE patients 30,31 . Moreover, within SLE migraineurs no relation between brain MRI lesions and anti‐phospholipid antibodies or abnormal coagulation parameters could be established 31 .…”

H-magnetic resonance spectroscopy: diagnostic tool in recurrent headache in systemic lupus erythematosus. A case report

“…A decrease in Naa in SLE patients has been reported in the literature and probably reflects neuronal loss and dysfunctions [5] , [22] .…”

“…To date, the specific cause of the high frequency of headaches in SLE patients has not been determined; circulating cytokines, cerebrovascular insult, or neuronal injury could be involved [3] , [4] . The relationship between headache and neuroradiological findings in these patients is also not well known [5] .…”

Migren ve Hastalık Birlikteliği

“…It was reported that it arised from vascular, neuronal and endothelial cell dysfunction and was closely related with disease exacerbations. In patients with Lupus, any headache was found with a rate of 32-78% and the prevalence of isolated migraine was found to be 25-66% (88,89).…”