Recurrent Granular Corneal Dystrophy

Stuart, John C.; Mund, Michael L.; Iwamoto, Takeo; Troutman, Richard C.; White, Henry; DeVoe, Arthur Gerard

doi:10.1016/0002-9394(75)90451-1

Cited by 40 publications

(14 citation statements)

References 11 publications

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“…11 Although the epithelial basement membrane may be destroyed, Bowman's layer may not be affected 11 or may be markedly attenuated or absent. 3,4 These recurrences support the contention that keratocytes are slowly replaced by those of the recipient in whom the inherited defect is located. 2 Lyons and colleagues 12 have suggested that the vortex pattern of the corneal opacities recurring in the grafted cornea is more consistent with an epithelial or tear film origin for the dystrophy, rather than the classical assumption of a stromal disease and this epithelial origin is supported by Johnson and coworkers.…”

Section: Recurrencesupporting

confidence: 64%

“…Typically, visual acuity of patients with granular dystrophy is not obstructed until late in the disease, 3,4 which may be in the fourth or fifth decade 7 or even later. 4 In a study of 71 patients, Moller 8 reported visual loss as minimal in the early stages, reducing to around 6/12 in adults and between 6/12 and 6/60 in elderly patients.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] Its mode of inheritance is autosomal dominant 1,3-5 with a 100 per cent penetrance, 6 although occasionally there may be a noncontributory family history. 4 Neither the siblings nor the offspring of the patient reported here were available for examination to determine occurrence of the dystrophy in the family.…”

Section: Discussionmentioning

confidence: 99%

“…3 More recently, phototherapeutic keratectomy (PTK) with a 193 nm excimer laser has been advocated as treatment for granular dystrophy. [14][15][16] Ablation zones of 5.5 to 6.0 mm have been used, with an ablation depth of 110 microns.…”

mentioning

confidence: 99%

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Granular dystrophy of the cornea

Collin

Hendicott

1999

Clinical and Experimental Optometry

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Background: Granular corneal dystrophy is the commonest of the dystrophies and usually results in visual disability in the fourth or fifth decades. Case history: A patient with granular corneal dystrophy is reported and the clinical characteristics described. Discussion: The classical clinical features and the pathology and management of granular dystrophy are reviewed. Two unusual variations of the corneal dystrophy, namely, juvenile granular dystrophy and Avellino dystrophy, which is a concurrence of the features of granular and lattice dystrophies, are also described.

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Section: Recurrencesupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Granular dystrophy of the cornea

Collin

Hendicott

1999

Clinical and Experimental Optometry

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“…[6][7][8] However, GCDs are known to recur within the graft over several years following keratoplasty 9 or PTK. 10 The recurrences often take the form of diffuse subepithelial deposits after keratoplasty 11 or PTK, 10 and recurrences at the host-graft interface of the stroma are also sometimes observed after LKP. 1 The superficial nature of recurrences may make these amenable to surgical removal by lamellar excision.…”

Section: Introductionmentioning

confidence: 99%

Electrolytic removal of recurrence of granular corneal dystrophy

Mashima

Kawashima

Yamada

2003

Eye

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Aims To report the efficacy of corneal electrolysis for the treatment of recurrent corneal opacities at the subepithelial region or at the host-graft interface of the stroma in granular corneal dystrophy (GCD). Methods In patients with recurrences of opacities at the host-graft interface of the stroma after lamellar keratoplasty, the deep aspect of the graft was partially separated from host tissue to expose the deposits. The graft was everted, and electrolysis was applied directly to remove the deposits attached to both surfaces of the host and the graft. Then the graft was returned to its place and sutured. In patients with diffuse subepithelial opacities following penetrating keratoplasty, electrolysis was applied directly to the corneal surface. Results Deposits in the subepithelial region or at the host-graft interface of the stroma disappeared following treatment, and vision recovered. However, GCD recurred 2-3 years after the treatment. Conclusions Corneal electrolysis is a simple, easy, and inexpensive way to remove deposits that recur after lamellar or penetrating keratoplasty for GCD. Eye (2003) 17, 975-981.

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