Recurrent Glioblastoma—Molecular Underpinnings and Evolving Treatment Paradigms
Christopher Chang,
Velina S. Chavarro,
Jakob V. E. Gerstl
et al.
Abstract:Glioblastoma is the most common and lethal central nervous system malignancy with a median survival after progression of only 6–9 months. Major biochemical mechanisms implicated in glioblastoma recurrence include aberrant molecular pathways, a recurrence-inducing tumor microenvironment, and epigenetic modifications. Contemporary standard-of-care (surgery, radiation, chemotherapy, and tumor treating fields) helps to control the primary tumor but rarely prevents relapse. Cytoreductive treatment such as surgery h… Show more
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