Recurrent giant phyllodes tumour in a 17-year-old female: a rare case report

Abstract

Phyllodes tumours (PTs) are rare fibroepithelial tumours of the breast with incidence accounting for <1% in the general population. Availability of reports on PTs with size of 31 cm or more in diameter in the literature are extremely rare. Herein, the case of a 17-year-old female patient with a giant recurrent right breast PT is reported. Histologically, the tumour showed proliferation of stromal tumour cells consisting of spindle cells with uniform nuclear chromatin, inconspicuous nucleoli, abundant eosinophilic cytoplasm and proliferation labelling index for Ki67 of <10%. PTs require meticulous surgical excision due to the fact that they have a high rate of recurrence and status of surgical margins must be included in the pathology report. This is because recurrent cases of PTs tend to grow faster than the primary ones with a high chance of transforming to malignancy.

Phylloides: Uncommon ulcerated breast tumor diagnosed at Singida regional referral hospital. Case report

“…First it will tell us histologically that it is phylloides and not otherwise and second it will give malignance status of the phylloides which can be benign, borderline or malignant. For this case it was confirmed phylloides tumor and was benign [ 2 , 7 ].…”

“…A systematic review and meta-analysis study done by Lu et al in China reported the pooled local recurrence rates for benign, borderline and malignant patients to be 8, 13 and 18%, respectively. This shows that the tendency of patients to recur locally increases with increase in aggressiveness of the tumor [ 1 , 7 ].…”

Immediate Breast Reconstruction in an 11-year-old Girl with a Large Malignant Phyllodes Tumor

“…10 A review of the literature reveals only 20 published cases of PTs in adolescents. 1,11 Of those existing reports, only one describes the reconstructive approach following mastectomy. 12 That case differs from ours in that the patient had reached full skeletal maturity and complete breast development at the time of diagnosis.…”

Phyllodes tumor in an adolescent female

“…These are fast growing tumors and can reach a median size of 4 cm and sometimes can grow up to 50 cm. 3 Mammography shows round densities with smooth borders and is distinguishable from fibroadenoma. Phyllodes tumor were classified as benign (70%), borderline (15%), or malignant (15%) based on histologic tumor characteristics i.e., cellular atypia, stromal overgrowth, tumor margins, tumor necrosis and mitotic count.…”