Recurrent giant fibroadenomas with transformation to cystosarcoma phyllodes in a 17-year-old girl: a rare case report from Syria

Abstract

BackgroundFibroadenoma is the most prevalent benign breast lesion that generally affects middle-aged women; it is rare in adolescents and younger children. The transformation into malignancy is not common. However, multiple recurrences of rapidly enlarging fibroadenomas suggest a high possibility of transforming into phyllodes tumors, which are uncommon fibroepithelial lesions that account for 0.3–0.5% of female breast tumors and typically present in premenopausal women.Case presentationWe report a case of a 17-year-old Syrian girl who previously had three episodes of recurrence of multiple rapidly enlarging fibroadenomas in her left breast and underwent three operations for complete resection of the lesions. However, a few months later, she was readmitted with multiple large masses in the same breast, and pathological findings confirmed a surprising combination of multiple fibroadenomas for the fourth time with a malignant phyllodes tumor (cystosarcoma phyllodes). The patient underwent lumpectomies followed by adjuvant radiotherapy. Long-term follow-up was recommended.ConclusionOur patient had an extraordinary number of episodes of recurrence at a young age and a rare combination of malignant and benign lesions in the same breast with multiple recurrences. We present her unique, very challenging case with the aim of highlighting the importance of clinical correlation, detailed diagnosis, and careful follow-up.

Clinicopathological profile of breast lesions and their management in paediatric patients seen in a tertiary health facility in Southern Nigeria

“…The suggestion by some authors to adopt watchful waiting, after imaging or histopathological examination of biopsies established that a breast lump was benign, does not consider the psychological burden the presence of such a lump places on the patient. [19,20] It is reassuring that despite suggestions of a reduction in the age of incidence of breast cancer, there was no case in which malignancy was identified in our series.…”

Dev juvenil fibroadenomun yönetiminde batwing mastopeksi yöntemi ile birlikte meme koruyucu cerrahi: 12 yaşinda kız olgu sunumu

“…Giant juvenile fibroadenomas may mimic malignant breast tumours because of their rapid growth. Whereas malignant transformation is rare in fibroadenomas; phyllodes tumors and adenocarcinomas should be evaluated in differential diagnosis [13,14].…”

Pengaruh Pendidikan Kesehatan terhadap Pengetahuan SADARI sebagai Deteksi Dini Tumor Payudara pada Remaja Putri di SMA N 3 Padang

“…Pada laporan kasus tersebut didapatkan hasil bahwa pada anak usia 17 tahun ditemukan fibroadenoma mamae. 9 Baswedan dkk (2014) menyebutkan bahwa wanita yang pernah menderita fibroadenoma mammae memiliki peningkatan risiko untuk mengalami kanker payudara 8,95 kali lebih tinggi, peningkatan risiko ini berhubungan dengan riwayat tumor jinak yang terjadi sebelumnya dimana pernah terjadi proliferasi sel secara berlebihan. 10 Data WHO memprediksi pada tahun 2030 akan terjadi peningkatan penderita kanker di Indonesia sampai tujuh kali lipat, dikarenakan banyaknya perempuan usia produktif dan pola hidup yang sudah beralih dari pertanian menjadi perindustrian, sehingga hal ini mengakibatkan tingginya risiko fibroadenoma mammae pada perempuan dengan tingkat prevelensi mencapai 9,6 per 1.000 orang.…”