Recurrent Genito-Oral Aphthosis and Uveitis With Hypopyon (Behcet's Syndrome)

Curth, Helen Ollendorff

doi:10.1001/archderm.1946.01510370063005

Cited by 112 publications

(30 citation statements)

References 14 publications

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“…One of them was a 30-year-old German teacher, the others were Mediterranean workers born in Italy, Greece, and Turkey. The diagnosis of Behcet's disease was established ac cording to the criteria of Curth [9]. All patients had been chronically affected with the pertinent symptoms and signs for 2-9 years, when they were transferred to our hospital (table I).…”

Section: Methodsmentioning

confidence: 99%

Inhibition of the Fibrinolytic System in Behçet’s Disease?

Asbeck¹,

Meyer-Boernecke²,

Loo³

1977

Pathophysiol Haemos Thromb

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Suppression of the fibrinolytic system is a well-known phenomenon in patients with Behçet’s disease. It is generally explained by an increase in the inhibitory potential. In order to prove this theory, the fibrinolytic system was investigated in 5 male patients with severe chronic Behçet’s disease. By the venous occlusion test, a marked suppression of the activatability of the system could be demonstrated (euglobulin lysis time, various fibrin plate assays). Results of analysis of the known inhibitors could not explain the phenomenon: antithrombin III, α₂-macroglobulin, fast-reacting α₂-antiplasmin, C1 inactivator, and the plasmin-antiplasmin complex were normal. The only change was an elevation of α₁-antitrypsin and fibrinogen in 4 patients possibly due to an acute phase reaction. In addition to the possibility of a hitherto unidentified inhibitor, therefore, a decrease in production or in release of vessel wall activators must also be considered in the pathogenesis of this disorder.

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Section: Methodsmentioning

confidence: 99%

Inhibition of the Fibrinolytic System in Behçet’s Disease?

Asbeck¹,

Meyer-Boernecke²,

Loo³

1977

Pathophysiol Haemos Thromb

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“…Its importance has been stressed by both the Behçet's Disease Research Committee of Japan and the International Study Group of Behçet's Disease (18,22), as well as by a number of authorities (12)(13)(14)(15). Because of the different techniques put forward including the type of edge, size, and way of introducing the needle, time elapse before reading the test result, and use or no use of saline (38 -41), the International Study Group for Behçet's Disease described the technique.…”

Section: Pathergy Testmentioning

confidence: 99%

“…George and associates defined it as a chronic systemic, relapsing multisystem vasculitis (11). In a trial to put together the various clinical findings associated with BD, a number of suggestive criteria were put forward for diagnosis by a number of authorities (12)(13)(14)(15)(16)(17)(18)(19)(20)(21). This reflected the absence of collaborative criteria that could accommodate the different manifestations of this disease around the world.…”

Section: Introductionmentioning

confidence: 99%

Immunopathogenesis of Behçet's Disease

Hegab¹,

Al-Mutawa²

2000

Clinical Immunology

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“…At the cellular level, it is considered to be an upregulated inflammatory response [236,281]. Curth [282,283] was the first to recognize it as one of the main manifestations of BD and Hewitt et al [284,285] later considered it as one of the main criteria for the diagnosis of BD, which was then confirmed by the Behcet's Research Committee of Japan and the International Study Group (ISG) of Behcet's Disease (Tables 2 and 3) [55,56]. Due to controversy surrounding the technique, ISG of BD described the technique in detail.…”

Section: Pathergymentioning

confidence: 99%

Behcet’s disease

Al-Mutawa¹,

Hegab

2004

Clin Exp Med

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Behcet's disease is a recurrent multisystem vasculitis that can affect any organ or system, but was originally described as orogenital ulcerations and uveitis. Specific criteria have been proposed for diagnosis and identification of affected organs by different national authorities. Behcet's disease is proposed to be due to an antigen/antibody reaction. The antigen can be external (microbial or other) or self-antigen. Self-antigens include HLA-B, S and interphotoreceptor retinoid binding protein, the oral mucosal antigens, and alphatropomycin. The antibody reaction manifests as changes common to any inflammatory process. Circulating immune complexes and neutrophil hyperactivity are present with the expression of adhesion molecules related to disease activity associated with phenotypic and functional aberrations affecting both Th1 and Th2 activity. The results in an increase of interleukin-4, -10, and -1B and interleukin-2 receptors with deficient interleukin-12, interferon-gamma, and expression of cell adhesion CDII/CD18, accompanied by increased B cells secreting IgG. The clinical picture varies according to the organ affected; emphasis is placed on those of diagnostic importance and those affecting morbidity and mortality. The histopathology demonstrates vasculitis with inflammatory cell infiltration, the endothelium expressing ICAM-1 and E-selectin, vascular occlusion with sequences. Treatment includes corticosteroids. Other immunosuppressant and biological agents include anti-tumor necrosis factor, interferon-alpha, Campath-1, and the S antigen. Colchicine and other miscellaneous therapies are included.

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Recurrent Genito-Oral Aphthosis and Uveitis With Hypopyon (Behcet's Syndrome)

Cited by 112 publications

References 14 publications

Inhibition of the Fibrinolytic System in Behçet’s Disease?

Inhibition of the Fibrinolytic System in Behçet’s Disease?

Immunopathogenesis of Behçet's Disease

Behcet’s disease

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