Recurrent Fever Episodes with Arthralgia or Hyperesthesia – Have You Ruled Out Parvovirus B19?

Marek, Iwona; Metzler, Markus; Reutter, G.; Holter, Wolfgang

doi:10.1055/s-0030-1265136

Cited by 1 publication

(1 citation statement)

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“…Other accompanying symptoms included fatigue, night sweats, headache, abdominal pain, skin rash, hyperesthesia, swelling of the hands and feet, erythema nodosum, increased inflammatory markers and moderate anemia. Diagnosis was based on serologic and PCR tests [ 20 , 21 ].…”

Section: Infectious Causesmentioning

confidence: 99%

Recurrent Fever in Children

Torreggiani

Filocamo

Esposito

2016

IJMS

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Children presenting with recurrent fever may represent a diagnostic challenge. After excluding the most common etiologies, which include the consecutive occurrence of independent uncomplicated infections, a wide range of possible causes are considered. This article summarizes infectious and noninfectious causes of recurrent fever in pediatric patients. We highlight that, when investigating recurrent fever, it is important to consider age at onset, family history, duration of febrile episodes, length of interval between episodes, associated symptoms and response to treatment. Additionally, information regarding travel history and exposure to animals is helpful, especially with regard to infections. With the exclusion of repeated independent uncomplicated infections, many infective causes of recurrent fever are relatively rare in Western countries; therefore, clinicians should be attuned to suggestive case history data. It is important to rule out the possibility of an infectious process or a malignancy, in particular, if steroid therapy is being considered. After excluding an infectious or neoplastic etiology, immune-mediated and autoinflammatory diseases should be taken into consideration. Together with case history data, a careful physical exam during and between febrile episodes may give useful clues and guide laboratory investigations. However, despite a thorough evaluation, a recurrent fever may remain unexplained. A watchful follow-up is thus mandatory because new signs and symptoms may appear over time.

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Section: Infectious Causesmentioning

confidence: 99%