Recurrent extramedullary plasmacytomas without multiple myeloma: A case report with review of the literature.

Raghuram, Saadvik; Faizal, Bini; Sanjeevan, KV; Eapen, Malini; Nair, Indu R.; Philip, Arun; Pavithran, Keechilat

doi:10.1016/j.ctarc.2022.100550

Cited by 2 publications

(3 citation statements)

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“…Cytogenetic profiles of plasmacytomas in bone marrow samples should be evaluated with fluorescence in situ hybridization because t (11; 14), t (4; 14), del (13q) and 1q gain were associated with recurrence of EMP and prognosis with MM. [ 22 ] Our case had no bone marrow fluorescence in situ hybridization information, so we did not assess the nasal plasma cell tumor cell genetics spectrum, this may affect the potential treatment decisions and it is the limitations of our case study. Endoscopic nasal surgery is a relatively safe and minimally invasive technique that provides sufficient and rapid delivery of high-quality tissue samples for a definitive diagnosis and also provides an effective resection method to remove the tumor from the cavity, which can significantly alleviate symptoms and inhibit the progression of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Through systematic and gradual screening of literature, 20 full texts including 23 patients were finally obtained. [2,5,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] Including our patient, a total of 24 patients consisting of 16 men and 8 women, were included in this study. The median age of onset in men was about 52.9 years, and the age ranged from 45 to 63 years.…”

Section: Literature Reviewmentioning

confidence: 99%

“…Alive Iran [22] M/48 Xing MH/2021/ USA [24] M/70 EMP on MRI have been identified, such as the presence of dilated features, the absence of infiltrative features and the presence of significant contrast enhancement. [37] Diffusion was significantly limited on DWI, and ADC values were significantly lower than those of benign lesions and epithelial-derived malignancies, which contributed to the differential diagnosis.…”

Section: Tablementioning

confidence: 99%

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Diagnosis and management of extramedullary plasmacytoma in nasal cavity: Clinical experience and literature review

et al. 2023

Medicine

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Nasal extramedullary plasmacytoma (EMP) is a rare plasma cell tumor that occurs in the soft tissue of the nasal cavity, and its imaging characteristics are still unclear. The purpose of this study was to investigate the clinical features, imaging findings, treatment, survival analysis, and prognosis of nasal EMP, and to provide a systematic review of the patients we treated and the published literature. A 45-year-old female patient who presented with epistaxis with nasal obstruction was recommended for magnetic resonance imaging to assess the nature of the lesion. On magnetic resonance imaging, abnormal signal shadow can be seen in the right nasal cavity. Diffusion weighted imaging showed signal of the lesion was significantly limited, presenting high signal, with a low apparent dispersion coefficient, and the lesion was significantly enhanced on contrast-enhanced scan. Combined with the clinical manifestations of the patient, who was initially considered to have a hemangioma. She underwent endoscopic nasal surgery under general anesthesia to remove the mass, and the final pathology confirmed it was EMP. However, the final pathology confirmed EMP. Five months later, the patient came to our hospital for follow-up and underwent fluorine-18-fluorodeoxyglucose/positron emission tomography/computed tomography scan, which showed no recurrence of the lesion and no transformation of multiple myeloma. The nasal EMP imaging findings were mostly soft tissue masses with uniform density or signal, which were significantly enhanced by enhancement scan, high signal on diffusion weighted imaging and low signal on apparent dispersion coefficient. Immunohistochemical staining for CD38, CD138, and CD79a was positive in most of the cases evaluated, while CD20 and CD10 were negative. The absence of dilated features, infiltrative features and the presence of significant contrast enhancement may be relatively specific imaging findings of nasal EMP. The prognosis of nasal EMP is good, and recurrence, metastasis, and transformation into multiple myeloma are rare. Because the lesions are sensitive to radiotherapy, surgical resection combined with radiotherapy is a more effective treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Literature Reviewmentioning

confidence: 99%

Section: Tablementioning

confidence: 99%

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Diagnosis and management of extramedullary plasmacytoma in nasal cavity: Clinical experience and literature review

et al. 2023

Medicine

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Nasal cavity extramedullary plasmacytoma: literature review and clinical experience

Vivekanand,

Tara

2024

Romanian Journal of Rhinology

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BACKGROUND. Extramedullary plasmacytoma is an extremely rare solitary plasma cell neoplasm that occurs in locations other than bone, without involving the bone marrow. It is commonly located in the upper aerodigestive tract. In the head and neck region, the most frequent location is the sinonasal region. MATERIAL AND METHODS. A systemic review in accordance with the PRISMA guidelines was done with research works in PubMed, Elsevier database, Cochrane library, Web of Science, Scopus, Crossref and Google Scholar. The search was carried out using the keywords “plasmacytoma and nose”, “extramedullary plasmacytoma”, “extramedullary plasmacytoma of nose”, “plasmacytoma and nasal cavity”, and “extramedullary plasmacytoma of nasal cavity”. RESULTS. We analysed 27 research works with a total number of 32 cases. The most common presenting symptoms were nasal cavity bleeding. The disease showed a male preponderance (78.1%). Bone erosion was seen in 7 cases. The histopathological examination showed plasma cells arranged predominantly as a uniform population or sheet-like appearance. A common immunohistochemical marker was CD138 (11 cases). Treatment was primarily radiotherapy (43.7%). We are also reporting a case of a 53-year-old male with plasmacytoma of the middle turbinate managed by wide resection and postoperative radiotherapy. CONCLUSION. Though a less common condition, in a case of polypoidal-like lesion with bleeding tendency, the clinician should keep in mind the possibility of extramedullary plasmacytoma. The diagnosis is made with histopathological examination and immunohisto-chemistry of the tissue involved. Treatment can be radiotherapy, surgery, or a combination of modalities.

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Recurrent extramedullary plasmacytomas without multiple myeloma: A case report with review of the literature.

Cited by 2 publications

References 9 publications

Diagnosis and management of extramedullary plasmacytoma in nasal cavity: Clinical experience and literature review

Diagnosis and management of extramedullary plasmacytoma in nasal cavity: Clinical experience and literature review

Nasal cavity extramedullary plasmacytoma: literature review and clinical experience

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