Recurrent evolution of two competing haplotypes in an insect DNA virus

Hill, Tom; Unckless, Robert

doi:10.5061/dryad.2fqz612mh

2020

DOI: 10.5061/dryad.2fqz612mh

|View full text |Cite

Recurrent evolution of two competing haplotypes in an insect DNA virus

Tom Hill,

Robert Unckless

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2020

Publication Types

Select...

Preprint2

Relationship

Self Cite2

Independent0

Authors

Journals

Cited by 2 publications

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Adaptation, ancestral variation and gene flow in a ‘Sky Island’Drosophilaspecies

Hill

Unckless

2020

Preprint

Self Cite

View full text Add to dashboard Cite

1Over time, populations of species can expand, contract, and become isolated, creating subpopulations that 2 can adapt to local conditions. Understanding how species adapt following these changes is of great interest, 3 especially as the current climate crisis has caused range shifts for many species. Here, we characterize how 4 Drosophila innubila came to inhabit and adapt to its current range: mountain forests in southwestern USA 5 separated by large expanses of desert. Using population genomic data from more than 300 wild-caught 6 individuals, we examine four distinct populations to determine their population history in these mountain-7 forests, looking for signatures of local adaptation to establish a genomic model for this spatially-distributed 8 system with a well understood ecology. We find D. innubila spread northwards during the previous 9 glaciation period (30-100 KYA), and has recently expanded even further (0.2-2 KYA). Surprisingly, D. 10 innubila shows little evidence of population structure, though consistent with a recent migration, we find 11 signatures of a population contraction following this migration, and signatures of recent local adaptation 12 and selective sweeps in cuticle development and antifungal immunity. However, we find little support for 13 recurrent selection in these genes suggesting recent local adaptation. In contrast, we find evidence of 14 recurrent positive selection in the Toll-signaling system and the Toll-regulated antimicrobial peptides. 15 65 evolutionary change and this is particularly interesting regarding the coevolution with pathogens (DYER 66 AND JAENIKE 2005; UNCKLESS 2011a). We also wanted to understand how D. innubila adapt to their local 67

show abstract

Adaptation, ancestral variation and gene flow in a ‘Sky Island’Drosophilaspecies

Hill

Unckless

2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Recurrent evolution of two competing haplotypes in an insect DNA virus

Hill

Unckless

2020

Preprint

Self Cite

View full text Add to dashboard Cite

1Hosts and viruses are constantly evolving in response to each other: as hosts attempt to suppress the virus, 2 the virus attempts to evade and suppress the host's immune system. This arms race results in the evolution 3 of novel pathways in both the host and virus to gain the upper hand. Here we describe the coevolution 4 between Drosophila species and a common and virulent DNA virus. We identify two distinct viral types 5 that differ 100-fold in viral titer in infected individuals, with similar effects across multiple species. Our 6 analysis suggests that one of the viral types appears to have recurrently evolved at least 4 times in the past 7 ~30,000 years, including in another geographically distinct species, due to the high effective mutation rate 8 which increases with titer. The higher titer viral type is associated with suppression of the host immune 9 system and an increased transmission rate compared to the low viral titer type. Both types are maintained 129 2016; PALMER et al. 2019).130 Among populations there is a positive correlation between the frequency of the High type and 131 overall DiNV infection frequency (Figure 1D, GLM logistic regression z-value = 6.104, p-value = 132 0.00883), suggesting that the High type may have a higher effective transmission rate, resulting in a 133 higher number of new individuals infected, per DiNV infected individual. The transmission rate appears 134 157 the frequency of the virus infection. E. Expression (in FPKM per viral particle) of gp83 increases with the 158 number of High DiNV haplotype SNPs. 159 160

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Recurrent evolution of two competing haplotypes in an insect DNA virus

Cited by 2 publications

References 2 publications

Adaptation, ancestral variation and gene flow in a ‘Sky Island’Drosophilaspecies

Adaptation, ancestral variation and gene flow in a ‘Sky Island’Drosophilaspecies

Recurrent evolution of two competing haplotypes in an insect DNA virus

Contact Info

Product

Resources

About