Recurrent Endocarditis Caused by Streptococcus pneumoniae

Lindberg, Jens; Fangel, Søren

doi:10.1080/00365549950163888

Cited by 9 publications

(2 citation statements)

References 13 publications

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“…In addition, several streptococcal species are known to cause IE [31]. We would want a polyvalent vaccine to have broad protection against different streptococcal species [32]; thus, such conservation is desirable. We identified conserved proteins by comparative genomic analyses.…”

Section: Resultsmentioning

confidence: 99%

Pooled Protein Immunization for Identification of Cell Surface Antigens in Streptococcus sanguinis

Kitten

Munro

et al. 2010

PLoS ONE

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BackgroundAvailable bacterial genomes provide opportunities for screening vaccines by reverse vaccinology. Efficient identification of surface antigens is required to reduce time and animal cost in this technology. We developed an approach to identify surface antigens rapidly in Streptococcus sanguinis, a common infective endocarditis causative species.Methods and FindingsWe applied bioinformatics for antigen prediction and pooled antigens for immunization. Forty-seven surface-exposed proteins including 28 lipoproteins and 19 cell wall-anchored proteins were chosen based on computer algorithms and comparative genomic analyses. Eight proteins among these candidates and 2 other proteins were pooled together to immunize rabbits. The antiserum reacted strongly with each protein and with S. sanguinis whole cells. Affinity chromatography was used to purify the antibodies to 9 of the antigen pool components. Competitive ELISA and FACS results indicated that these 9 proteins were exposed on S. sanguinis cell surfaces. The purified antibodies had demonstrable opsonic activity.ConclusionsThe results indicate that immunization with pooled proteins, in combination with affinity purification, and comprehensive immunological assays may facilitate cell surface antigen identification to combat infectious diseases.

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Section: Resultsmentioning

confidence: 99%

Pooled Protein Immunization for Identification of Cell Surface Antigens in Streptococcus sanguinis

Kitten

Munro

et al. 2010

PLoS ONE

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“…Very few cases of recurrent PE are reported in the medical literature. To our knowledge, the last reported case of recurrent PE was by Lindberg and Fangel in 1999 [7]. Risk factors of PE include extremes of age, alcoholism, malnutrition, immunosuppression, and prior valvulopathy.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Mitral Valve Endocarditis Caused byStreptococcus pneumoniaein a Splenectomized Host

Shrestha

Chintanaboina

Pancholy

2013

Case Reports in Infectious Diseases

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A 72-year-old male with a remote history of splenectomy and two previous episodes of pneumococcal endocarditis of mitral valve presented with high-grade fever and confusion for 3 days. Nine months priorly, patient underwent mitral valve repair when he had the first episode of pneumococcal mitral valve endocarditis. He received pneumococcal vaccination two years ago. On examination during this admission, he was found to be febrile (104.3 F) and confused and had a grade 2/6 systolic murmur at the apex without any radiation. Laboratory data was significant for a white blood cell count of 22,000/mm3 (normal: 4000–11000/mm3). Blood cultures (4/4 bottles) grew penicillin-sensitive Streptococcus pneumoniae. Transesophageal echocardiogram revealed small vegetation on the posterior mitral leaflet without any evidence of abscess and severe mitral regurgitation. Patient clinically responded to intravenous ceftriaxone. However, due to recurrent pneumococcal mitral valve endocarditis and severe mitral regurgitation, the patient underwent mitral valve replacement. Patient had an uneventful recovery and was discharged home. Pneumococcal endocarditis itself is being uncommon in this current, penicillin, era; our case highlights the recurrent nature of pneumococcal endocarditis in a splenectomized host and the importance of pursuing aggressive treatment options in this clinical scenario.

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Treatment of Native Valve Endocarditis: General Principles and Therapy for Specific Organisms

Vinh

Embil

2006

Endocarditis

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Recurrent Endocarditis Caused by Streptococcus pneumoniae

Cited by 9 publications

References 13 publications

Pooled Protein Immunization for Identification of Cell Surface Antigens in Streptococcus sanguinis

Pooled Protein Immunization for Identification of Cell Surface Antigens in Streptococcus sanguinis

Recurrent Mitral Valve Endocarditis Caused byStreptococcus pneumoniaein a Splenectomized Host

Treatment of Native Valve Endocarditis: General Principles and Therapy for Specific Organisms

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