Recurrent endobronchial inflammatory myofibroblastic tumors: Novel treatment options

Abstract

Endobronchial inflammatory myofibroblastic tumors (IMTs) rarely occur in children younger than 10 years of age and have intermediate malignant potential. A 7‐year‐old girl initially presented with pneumonia. After failing outpatient treatment, she re‐presented in status asthmaticus. Computed tomography showed a left mainstem endobronchial mass which was resected bronchoscopically. Pathology was consistent with IMT. Surveillance bronchoscopy identified a recurrence. Despite a left upper lobectomy, recurrence led to further treatment with celecoxib and argon plasma coagulation. Follow‐up bronchoscopy revealed complete resolution. She remains disease and symptom‐free at her six‐year follow‐up.

Anaplastic lymphoma kinase-positive pulmonary inflammatory myofibroblastic tumour: a case report

“…Ramirez et al . [ 25 ] reported a case treated with Celecoxib for 11 months and four sessions of argon plasma coagulation over the period. She remained in remission six years on [ 25 ].…”

Flexible bronchoscope for the treatment of intratracheal inflammatory myofibroblastic tumor in children: a case report and literature review

“…Studies have found that the diagnosis of IMT is mainly determined by histopathology and immunohistochemical examination through biopsy (13)(14)(15)(16)(17)(18)(19)(20)(21). The pathological manifestations of IMT are as follows: [1] A large number of proliferating spindle cells are arranged in bundles; [2] The nuclei may be slightly heteromorphic, with mitotic images occasionally seen; [3] Lack of pathological mitosis and coagulation necrosis; [4] A mixture of spindle cells, lymphocytes, plasma cells and eosinophils existed (2,27). Immunohistochemical examination of tissue biopsy showed that positive of vimentin, SMA, MSA and Desmin in the cytoplasm of spindle cell were characteristic manifestations of myo broblasts (11,27).…”

“…The pathological manifestations of IMT are as follows: [1] A large number of proliferating spindle cells are arranged in bundles; [2] The nuclei may be slightly heteromorphic, with mitotic images occasionally seen; [3] Lack of pathological mitosis and coagulation necrosis; [4] A mixture of spindle cells, lymphocytes, plasma cells and eosinophils existed (2,27). Immunohistochemical examination of tissue biopsy showed that positive of vimentin, SMA, MSA and Desmin in the cytoplasm of spindle cell were characteristic manifestations of myo broblasts (11,27). ALK expression was detected in nearly half of IMT patients (26), which was consistent with the cases collected in this study (Table 1).…”