Recurrent Encephalopathy with Transverse Myelitis: An Uncommon Presentation of Neurobrucellosis

Anadure, Ravi; Goel, Jitesh; Sahu, Samaresh; Vidhale, Tushar

doi:10.1055/s-0039-1700600

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…Moreover, the clinical manifestations of neurobrucellosis include headache, dizziness, vomiting, numbness of limbs, fatigue, disturbance of consciousness and seizures. Transverse myelitis was also previously reported as a main symptom [14]. In addition, heart damage from brucellosis can manifest as pericarditis and endocarditis.…”

Section: Discussionmentioning

confidence: 86%

A 10-year retrospective comparative analysis of the clinical features of brucellosis in children and adults

Chen

et al. 2021

J Infect Dev Ctries

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Introduction: Brucellosis is a zoonosis with a wide spectrum of clinical manifestations. However, it is still unclear whether the clinical manifestations in children are significantly different from those in adults. Methodology: Patients with brucellosis and treated at the General Hospital of Ningxia Medical University between 2009 and 2019 were divided into two groups; children (88) and adults (354). Thereafter, the records of the two groups were analyzed retrospectively. Results: The findings showed that: 1. School-age children, young and middle-aged individuals were more likely to suffer from brucellosis and most were male; 2. Fever and arthralgia were the most common manifestations in the two groups. In addition, fatigue and low back pain were rare in children although fever and lymphadenopathy were more common in this group. However, hepatomegaly and splenomegaly were common in both groups; 3. The most common complication was osteoarthritis and peripheral arthritis occurred more frequently in children. On the other hand, spondylitis was the most common in adults (this particularly involved the lumbar and sacral vertebrae); 4. An increase in the erythrocyte sedimentation rate, levels of the C-reactive protein and liver enzymes was common in both two groups; 5. There was no significant difference in the positive rate of the standard agglutination test between children (96.59%) and adults (95.20%). However, the positive rate of blood culture was higher in children (65.85%) than in adults (51.00%). Conclusions: Brucellosis causes damage to multiple systems and differences in clinical characteristics were found between children and adults.

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Section: Discussionmentioning

confidence: 86%

A 10-year retrospective comparative analysis of the clinical features of brucellosis in children and adults

Chen

et al. 2021

J Infect Dev Ctries

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“…The most common clinical presentation is meningitis. Brucellosis is a ubiquitous zoonosis worldwide that has been re-emerging in the past few years [3,10]. In Tunisia, the mean incidence of human brucellosis decreased from 354/100,000 cases in 2004 to 284/100,000 cases in 2005 [11].…”

Section: Discussionmentioning

confidence: 99%

The Re-emergence of a Forgotten Disease: Neurobrucellosis

Rekik¹,

Hammami²,

Chakroun³

et al. 2020

DSAHMJ

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Brucellosis may present with a broad spectrum of clinical manifestations. Neurobrucellosis (NB), an uncommon but a serious complication, may occur at any stage of the disease. We aimed to evaluate the clinical, diagnostic, therapeutic, and evolutionary features of NB. We conducted a retrospective study including all patients hospitalized for neurobrucellosis in the infectious diseases department between 1994 and 2018. The diagnosis was based on the association of neurological symptoms with bacteriological and/or serological confirmation of brucellosis in blood or Cerebrospinal Fluid (CSF). There were 16 patients (10 male) with NB. The median (range) age was 35 (24-48) years. The revealing symptoms were fever (n = 15), headache (n = 12), and vomiting (n = 9). CSF analysis showed lymphocytic pleocytosis (n = 9) and a high level of protein (n = 10). Brucella was isolated from the blood and CSF in two and five cases, respectively. All patients had a positive Brucella serological test. Eleven patients received rifampicin, doxycycline, and trimethoprim/sulfamethoxazole. The median (range) duration of treatment was 4.5 (3-5.3) months. The disease evolution was favorable in 13 cases. Sequelae were noted in one case. Two patients died. In cases of unusual neurological disorders, NB should be considered, especially in endemic areas. Prompt diagnosis and treatment are crucial in order to avoid serious complications and sequelae.

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“…Bu ölçütler dışında bazı çalışmalarda sadece serum ve/veya BOS'ta brusella antikorlarının "enzyme-linked immunosorbent assay" (ELISA) ile Şekil 5. Tedavi Edilmemiş Brusellozun Evrelerine Göre Antikor Yanıtları (27) saptanmasıyla nörobruselloz tanısı konulmuştur (42)(43)(44)(45)(46)(47)(48)(49)(50). Serum ve BOS'ta brusella antikorlarının sadece immünofloresan (IFA) veya kompleman fiksasyon testleriyle gösterilmesi yoluyla tanı konulan az sayıda olgu da bildirilmiştir (51,52).…”

Section: Nörobruselloz Tanı öLçütleriunclassified

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2023

Klimik Derg

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Although brucellosis is very common in the world and Türkiye, there are no evidence-based guidelines to guide the diagnosis and treatment of the disease. This guide has been prepared by the Turkish Society of Clinical Microbiology and Infectious Diseases to provide evidence-based recommendations to physicians from different specialties interested in the diagnosis and treatment of brucellosis. The recommendations of the Clinical Practice Guide Development Guide of the Infectious Diseases Society of America (IDSA) were taken as the basis for preparing this guide. The guideline preparation group determined 20 questions considered to be important in the diagnosis and treatment of brucellosis, and the publications that could answer these questions prepared in PICO (Population/Patient [P], Intervention [I], Comparison [C], Outcome [O]) format, were searched in ULAKBİM Tr Dizin, PubMed, Cochrane databases without date restrictions. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) Working Group method was used to rank the evidence and determine the strength of the recommendations for each PICO question and for each individual outcome. Meta-analyses of comparative clinical studies were performed to answer the PICO questions. Individual participant data (IPD) meta-analyses with data obtained from case reports and case series were conducted in the absence of comparative clinical studies. It is planned to update the recommendations at regular intervals in line with the results of new studies.

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Recurrent Encephalopathy with Transverse Myelitis: An Uncommon Presentation of Neurobrucellosis

Cited by 3 publications

References 8 publications

A 10-year retrospective comparative analysis of the clinical features of brucellosis in children and adults

A 10-year retrospective comparative analysis of the clinical features of brucellosis in children and adults

The Re-emergence of a Forgotten Disease: Neurobrucellosis

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