Recurrent dysphagia in a patient with chronic lymphocytic esophagitis

Niewiarowski, Tomasz J.; Stoll, Lisa

doi:10.1016/j.gie.2016.02.016

Cited by 8 publications

(6 citation statements)

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“…In up to one‐third of patients, the mucosa may be completely normal, while in others the mucosal surface shows rings, furrows, as well as strictures similar to those seen in patients with EoE (Fig. ) . EoE‐like changes seem to develop throughout the esophagus, with the mid‐esophagus being usually involved in conjunction with involvement of the proximal or distal esophagus.…”

Section: Endoscopic Appearance Of Lymphocytic Esophagitis and Overlapmentioning

confidence: 93%

“…They concluded that 83% of patients with EoE have at least one abnormality on endoscopy. A review of all the clinical studies and case reports published thus far includes 456 patients with lymphocytic esophagitis . Of these, endoscopic abnormalities were described in 359 (79%) patients.…”

Section: Endoscopic Appearance Of Lymphocytic Esophagitis and Overlapmentioning

confidence: 99%

“…1). 1,3,4,6,7,11,13,[17][18][19][20][21][22][23][24][25][26][27] EoE-like changes seem to develop throughout the esophagus, with the mid-esophagus being usually involved in conjunction with involvement of the proximal or distal esophagus. In fact, in a study by Xue et al, most biopsies from the mid-esophagus were found to have a higher intraepithelial lymphocyte count compared to biopsies obtained from other parts of the esophagus.…”

Section: Endoscopic Appearance Of Lymphocytic Esophagitis and Overlapmentioning

confidence: 99%

“…A review of all the clinical studies and case reports published thus far includes 456 patients with lymphocytic esophagitis. 1,3,4,6,7,11,13,[17][18][19][20][21][22][23][24][25][26][27] Of these, endoscopic abnormalities were described in 359 (79%) patients. The distribution of these endoscopic findings and the comparative frequencies of these findings in EoE (based on meta-analysis by Kim et al 28 ) is shown in Table 1.…”

Section: Endoscopic Appearance Of Lymphocytic Esophagitis and Overlapmentioning

confidence: 99%

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Lymphocytic esophagitis: an update on histologic diagnosis, endoscopic findings, and natural history

Patil

Hammer

Langer

et al. 2018

Annals of the New York Academy of Sciences

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Lymphocytic esophagitis is a histologic pattern of injury characterized by increased intraepithelial lymphocytes (>20/high-power field) with rare, or absent granulocytes. Lymphocytes tend to be more numerous in the peripapillary epithelium, and are often associated with evidence of mucosal injury, edema, and scattered dyskeratotic cells. More than a decade following its original description, lymphocytic esophagitis remains an enigmatic entity with variable clinical presentations, associated disorders, etiologies, treatment, and natural history. Most of the confusion regarding the clinical significance of this disorder stems from its diagnostic criteria: lymphocytic esophagitis is currently defined based entirely on histologic criteria, despite the common occurrence of lymphocytosis in a variety of unrelated inflammatory conditions of the esophagus. The goal of this review is to summarize the literature regarding lymphocytic esophagitis and focus on key clinicopathologic features that distinguish it from other esophageal disorders that can show increased numbers of intraepithelial lymphocytes.

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Section: Endoscopic Appearance Of Lymphocytic Esophagitis and Overlapmentioning

confidence: 93%

Section: Endoscopic Appearance Of Lymphocytic Esophagitis and Overlapmentioning

confidence: 99%

Section: Endoscopic Appearance Of Lymphocytic Esophagitis and Overlapmentioning

confidence: 99%

Section: Endoscopic Appearance Of Lymphocytic Esophagitis and Overlapmentioning

confidence: 99%

See 2 more Smart Citations

Lymphocytic esophagitis: an update on histologic diagnosis, endoscopic findings, and natural history

Patil

Hammer

Langer

et al. 2018

Annals of the New York Academy of Sciences

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“…Additionally, therapeutic esophageal dilations have been performed in patients presenting with dysphagia (with or without food impaction). Based on the few case reports published, dilation can be repeated as needed[ 26 , 31 ].…”

Section: Treatmentmentioning

confidence: 99%

Lymphocytic esophagitis: Still an enigma a decade later

Rouphael

Gordon

Thota

2017

WJG

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Lymphocytic esophagitis (LE) is a clinicopathologic entity first described by Rubio et al in 2006. It is defined as peripapillary intraepithelial lymphocytosis with spongiosis and few or no granulocytes on esophageal biopsy. This definition is not widely accepted and the number of lymphocytes needed to make the diagnosis varied in different studies. Multiple studies have described potential clinical associations and risk factors for LE, such as old age, female gender and smoking history. This entity was reported in inflammatory bowel disease in the pediatric population but not in adults. Other associations include gastroesophageal reflux disease and primary esophageal motility disorders. The most common symptom is dysphagia, with a normal appearing esophagus on endoscopy, though esophageal rings, webs, nodularities, furrows and strictures have been described. Multiple treatment modalities have been used such as proton pump inhibitors and topical steroids. Esophageal dilation seems to be therapeutic when dysphagia is present along with esophageal narrowing secondary to webs, rings or strictures. The natural history of the disease remains unclear and needs to be better delineated. Overall, lymphocytic esophagitis seems to have a chronic and benign course, except for two cases of esophageal perforation in the literature, thought to be secondary to this entity.

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