Recurrent cutaneous leiomyosarcoma

Abstract

Background. Soft tissue sarcomas comprise approximately 0.7% of all malignant neoplasms. Superficial leiomyosarcoma, a rare malignant lesion, constitutes 4.0‐6.5% of all soft tissue sarcomas, an overall incidence of approximately 0.04% among all cancers. Currently, less than 125 cumulative cases of cutaneous and subcutaneous leiomyosarcoma have been reported in the English literature. Methods. The authors report the case of a 70‐year‐old Japanese man with recurrent cutaneous leiomyosarcoma who was treated by wide local excision. A comprehensive literature survey is also presented. Results. The patient is free from recurrence 1 year after wide local excision of a second recurrence of cutaneous leiomyosarcoma. Moreover, superficial leiomyosarcoma can be subdivided into cutaneous leiomyosarcoma and subcutaneous leiomyosarcoma, based on histolopathologic and prognostic differences. Conclusions. The treatment of choice of superficial leiomyosarcoma is wide local excision. Cutaneous leiomyosarcoma is associated with local recurrence only, although subcutaneous leiomyosarcoma undergoes meta‐static spread in 30‐60% of cases, with a 30‐40% mortality rate. Cancer 1992; 70:490–492.

Giant Subcutaneous Leiomyosarcoma at Knee Joint:Malignant Tumour at Rare Site

“…Wide local excision with 3 to 5 cm surgical margin, has been recommended depending on the size of the tumour and recurrent presentation of tumour, is the primary treatment for the cutaneous leiomyosarcoma. [3][4][5][6][7] Factors correlated with the adverse prognosis with subcutaneous leiomyosarcoma include tumor size (>5cm), high mitotic rate, presence of necrosis, deep seated tumours with fascial involvement, and intratumoral vascular invasion. [1] Adverse prognostic factors present in our case were: giant size, high mitotic rate and deep seated tumour.…”

Leiomyosarcoma of the thumb: a case report and literature review

“…The microscopic features of this neoplasm have been described in detail by numerous investigators [1,4,5,6,7,8,9]. In contrast to benign smooth muscle tumors, LS cells exhibit a high mitotic rate.…”

“…Leiomyosarcoma is considered to be a tumor of adults, and most often develops in the uterus, the gastrointestinal tract, or the extremities [1,4,5,6,7,8,9]. The microscopic features of this neoplasm have been described in detail by numerous investigators [1,4,5,6,7,8,9].…”

Recurrent cutaneous leiomyosarcoma of the anterior abdominal wall: a rare tumor at an unusual site

“…11 Immunohistochemistry plays a key role in differential diagnosis and in pleomorphic or poorly differentiated cases. 7 Majority of the cases are positive for smooth muscle actin (SMA), desmin, heavy caldesmon and smooth muscle myosin. Amongst them SMA is the most sensitive marker and has been reported to be positive in 100% of the cases of LMS.…”

“…The trunk is rarely involved by LMS. 7 Preoperative misdiagnosis is frequent for LMS because of their rarity and non-specific presentation. We herein report the clinical, cytological, histopathological and immunehistochemical findings in a 50 years old female with recurrent cutaneous leiomyosarcoma arising in the anterior abdominal wall.…”