Recurrent choroidal melanoma after transscleral local resection with diffuse vitreous seeding

González, Pedro; Kemp, Ewan; Roberts, Fiona

doi:10.1007/s00417-009-1261-9

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Частота рецидивов связана с тем, что большие МХ агрессивно внедряются в окружающие ткани. Рецидивную меланому после транссклеральной эксцизии обнаруживают в сетчатке, в преретинальной мембране и стекловидном теле, во влаге передней камеры в виде отсева опухолевых клеток [64]. По сути, это IV стадия роста опухоли, когда локальное ее удаление противопоказано.…”

Section: хирургические методы леченияunclassified

Local treatment of choroidal melanoma: possibilities and limitations

Brovkina¹

2018

Vestn. oftal'mol.

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Local treatment of choroidal melanoma (CM) attracts the attention of many ophthalmology specialists, especially in recent years as the capabilities to target irradiation at small objects and possibilities of surgical interventions on the eyeball have expanded. The article discusses the medical indications for local treatment of CM. Review of literature of the last 16 years and author's own observations on CM patients who underwent almost all kinds of conventional methods of local treatment allowed thorough analysis of indications and counter-indications for their usage. Among the authors who favor local destruction and removal of large CM, the main indication is the possibility to preserve vision and anatomical structures of the eye. This led to unreasonably wide spread of local destruction (removal) of large CM, primarily the endovitreal resection method. However, such metastasis risk factors as CM size and its localization are being overlooked. Literature analysis and author's own observations helped validate the unsafety of the local treatment of large CM. The article features long-term results of contact and distant radiation therapy, and presents CM metrics for best therapeutic effect.

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Section: хирургические методы леченияunclassified

Local treatment of choroidal melanoma: possibilities and limitations

Brovkina¹

2018

Vestn. oftal'mol.

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Vitreous Seeding of Choroidal Melanoma

Raval

Bowen

Soto

et al. 2021

Retina

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Purpose: To report a case of vitreous seeding in a medium-sized choroidal melanoma and review the literature.Methods: Observational case report and review of literature for pathogenesis, role of vitreous biopsy, and treatment outcomes.Results: A case of 57-year-old man diagnosed with vitreous seeding in the left eye 1 year after episcleral brachytherapy for medium-sized choroidal melanoma. The patient was initially diagnosed to have subretinal and vitreous hemorrhage due to rupture of a retinal artery macroaneurysm for which focal laser and intravitreal antivascular endothelial growth factor injections were administered. Over the next 9 months, the vitreous hemorrhage cleared and choroidal melanoma with retinal invasion became evident. One year after brachytherapy, the primary tumor regressed with resolution of surrounding subretinal fluid and hemorrhage. However, gradual decline in the visual acuity from 20/50 to 20/500 with increase of pigmented debris over the retinal surface and in the vitreous cavity was noted. A vitreous biopsy confirmed the presence of viable melanoma cells (epithelioid type), and the eye was enucleated. Histopathology showed microscopic persistence of primary tumor with diffuse vitreous seeding.Conclusion: Vitreous seeding of choroidal melanoma poses a diagnostic and management challenge.

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Recurrent choroidal melanoma after transscleral local resection with diffuse vitreous seeding

Cited by 2 publications

References 8 publications

Local treatment of choroidal melanoma: possibilities and limitations

Local treatment of choroidal melanoma: possibilities and limitations

Vitreous Seeding of Choroidal Melanoma

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