Recurrent Cardiac Intimal (Spindle Cell) Sarcoma of the Left Atrium

Li, Zhe; Hsieh, Tyken C.; Salehi, Ali

doi:10.1053/j.jvca.2011.07.027

Cited by 48 publications

(58 citation statements)

References 5 publications

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“…Intimal (spindle cell) sarcomas are mesenchymal tumours, more commonly encountered in large arterial blood vessels and extremely rare in the heart, with only 3 cases reported [4–6]. Intimal sarcomas affect the pulmonary artery more than the aorta (165 versus 100 reported patients) [10–12].…”

Section: Discussionmentioning

confidence: 99%

“…Chemotherapy and radiation therapy have limited benefit [19]. Although surgery with negative resection margins is the only mainstay of successful treatment, complete tumour resection is possible in less than 50% of patients [4]. As life expectancy is twice as long for patients who undergo complete tumour resection [20], this indicates that early diagnosis and treatment have important prognostic and therapeutic implications.…”

Section: Discussionmentioning

confidence: 99%

“…The most common cardiac sarcoma is the angiosarcoma (about 37%) [1] while others include undifferentiated sarcoma (24%), malignant fibrous histiocytoma (MFH) (11%–24%), leiomyosarcoma (8%-9%), and osteosarcoma (3%–9%) [1]. Less encountered primary tumours of the heart include rhabdomyosarcoma, liposarcoma, fibrosarcoma, synovial sarcoma, and hemangiopericytoma, with the least reported cardiac tumours being the intimal (spindle cell) sarcomas [1, 4–6]. …”

Section: Introductionmentioning

confidence: 99%

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Primary Intimal (Spindle Cell) Sarcoma of the Heart: A Case Report and Review of the Literature

Ibrahim

Luk

Singhal

et al. 2013

Case Reports in Medicine

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Intimal (spindle cell) sarcomas of the left atrium are extremely rare primary cardiac tumours with three cases reported (Li et al. (2013), Cho et al. (2006), and Modi et al. (2009)). We present a 69-year-old man who first came to medical attention after experiencing abdominal discomfort. He had a 30 lb weight loss apparently due to dieting. He denied any other constitutional symptoms. His symptoms persisted despite a course of antibiotics for presumed diverticulitis. Laboratory values were within normal limits, though the haemoglobin was 131 g/L (normal: 140–180). Subsequent abdominal computed tomography (CT) scan revealed an abdominal wall mass and intracardiac lesion; the cardiac mass was further characterized by transesophageal echo (TEE), magnetic resonance imaging (MRI), and dedicated cardiac CT. TEE revealed a mass attached to the posterolateral wall of the left atrium above the mitral annulus, and the cardiac CT and MRI confirmed the TEE findings. The patient underwent extensive surgical resection and repair of the left side of the heart. Postoperatively, he developed acute renal failure requiring dialysis and reintubation for volume overload. He became acutely hypotensive, developed multiorgan failure, and succumbed to his illness. Histopathologic examination of the left atrial mass showed an intimal sarcoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Primary Intimal (Spindle Cell) Sarcoma of the Heart: A Case Report and Review of the Literature

Ibrahim

Luk

Singhal

et al. 2013

Case Reports in Medicine

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“…Symptomatic cardiac sarcomas usually present with dyspnea, orthopnea, paroxysmal nocturnal dyspnea, or lower extremity edema. 5,8 Patients can also present with the features of metastatic disease in advanced stages. 7 …”

Section: Discussionmentioning

confidence: 99%

Primary Intimal Sarcoma of the Left Atrium: An Incidental Finding on Routine Echocardiography

et al. 2016

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Cardiac sarcomas are extremely rare primary malignant tumors of the heart. In this article, we present the case of a 70-year-old female, who was found to have a left atrial mass during a routine outpatient transthoracic echocardiography. Further investigation with cardiac magnetic resonance imaging confirmed the presence of a bilobulated mass with heterogeneous enhancement. Left atrial myxoma was the first diagnostic consideration, followed by other primary cardiac tumors, and thrombus. The patient subsequently underwent resection of the mass, utilizing cardiopulmonary bypass. Upon pathological examination, the mass was found to be an intimal sarcoma. The objective of this report is to describe a case of this rare disease entity, and to discuss its presentation, pathological findings and management.

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“…About 25% of primary cardiac tumours are malignant of which sarcomas are most common entities, while lymphomas are rare (5%) 1. Among cardiac sarcomas, angiosarcoma (about 40%) is the most common form while others include undifferentiated sarcoma (24%), malignant fibrous histiocytoma (14–24%), leiomyosarcoma (8%) and osteosarcoma (6%), while the least reported malignant cardiac tumour is spindle cell sarcoma 1 4. Many sarcomas are misdiagnosed as myxomas because of their similar clinical presentation.…”

Section: Introductionmentioning

confidence: 99%

Right atrial spindle cell sarcoma as a rare cause of tricuspid stenosis

et al. 2016

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Spindle cell sarcomas of the right atrium are extremely rare primary cardiac tumours with very few cases reported in the medical literature. The prognosis of this malignant neoplasm remains poor due to delay in diagnosis, early metastasis and few available therapeutic options. It responds poorly to chemotherapy and radiotherapy. Surgical excision is the mainstay of treatment. We report a 42-year-old man, who presented to emergency room with dyspnoea and fatigue (New York Heart Association classification II) since 1 month. Transthoracic echocardiogram showed massive pericardial effusion with tamponade. The patient underwent emergency pericardiocentesis; postpericardiocentesis echocardiogram showed large right atrial mass involving the right ventricle and the tricuspid valve causing tricuspid stenosis. Findings were confirmed by cardiac CT scan. Percutaneous transvenous biopsy was carried out which revealed spindle cell sarcoma.

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Recurrent Cardiac Intimal (Spindle Cell) Sarcoma of the Left Atrium

Cited by 48 publications

References 5 publications

Primary Intimal (Spindle Cell) Sarcoma of the Heart: A Case Report and Review of the Literature

Primary Intimal (Spindle Cell) Sarcoma of the Heart: A Case Report and Review of the Literature

Primary Intimal Sarcoma of the Left Atrium: An Incidental Finding on Routine Echocardiography

Right atrial spindle cell sarcoma as a rare cause of tricuspid stenosis

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