Recurrent brief depression as an indicator of severe mood disorders

Angst, J.; Gamma, Alex; Ajdacic, Valadeta; Eich, Dominique; Pezawas, Lukas; Rössler, Wulf

doi:10.1017/cbo9780511544019.006

Cited by 4 publications

(18 citation statements)

References 35 publications

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“…In our model, family history of depression showed high odds (OR 2.57, 95 % CI 0.75-8.76) for the poorest course trajectory (class 5 ; class 1 reference), but this did not reach significance. Similarly, Angst et al (2009) could not demonstrate significant differences between chronic and non-chronic depressions related to family history of depression. Some other studies based on data-driven techniques identified family history of depressive symptomatology as a predictor for poor course trajectories.…”

Section: Discussionmentioning

confidence: 67%

“…They suggested that being female was more associated with transient and episodic forms of internalizing psychopathology. Both somatic co-morbidity (Angst et al 2009) and an earlier age of onset of depression were previously associated with chronic depressions, compared to non-chronic depressions (Mondimore et al 2006 ;Angst et al 2009). Although most studies to date have not used data-driven techniques, Olino et al (2010) did used LCGA and concluded that the persistent depression class they identified may reflect an earlyonset chronic form of depression (>70 % chance of being depressed at each time interval), whereas the second depression class they identified may reflect an adult-onset, episodic form of depression with <25 % chance of being depressed at each time interval.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, we explored the characteristics of each identified class and examined putative predictors of class membership, and hence course trajectory. In previous studies, sociodemographics, co-morbid anxiety disorders (Hayden & Klein, 2001), age of onset of depressive symptoms (Klein et al 1999 ;Angst et al 2009), childhood adversity (Hayden & Klein, 2001 ;Rhebergen et al 2011), somatic co-morbidity (Angst et al 2009), neuroticism (Hayden & Klein, 2001 ;Rhebergen et al 2011) and a family history of depression (Klein et al 1999 ;Stoolmiller et al 2005 ;Olino et al 2010) have been demonstrated to predict course trajectories. However, some inconsistencies exist.…”

Section: Introductionmentioning

confidence: 97%

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Course trajectories of unipolar depressive disorders identified by latent class growth analysis

et al. 2011

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Background. Current classification of unipolar depression reflects the idea that prognosis is essential. However, do DSM categories of major depressive disorder (MDD), dysthymic disorder (Dysth) and double depression (DD=MDD+Dysth) indeed adequately represent clinically relevant course trajectories of unipolar depression ? Our aim was to test DSM categories (MDD, Dysth and DD) in comparison with empirically derived prognostic categories, using a prospectively followed cohort of depressed patients.Method. A large sample (n=804) of out-patients with unipolar depression were derived from a prospective cohort study, the Netherlands Study of Depression and Anxiety (NESDA). Using latent class growth analysis (LCGA), empirically derived 2-year course trajectories were constructed. These were compared with DSM diagnoses and a wider set of putative predictors for class membership.Results. Five course trajectories were identified, ranging from mild severity and rapid remission to high severity and chronic course trajectory. Contrary to expectations, more than 50 % of Dysth and DD were allocated to classes with favorable course trajectories, suggesting that current DSM categories do not adequately represent course trajectories. The class with the most favorable course trajectory differed on several characteristics from other classes (younger age, more females, less childhood adversity, less somatic illnesses, lower neuroticism, higher extraversion). Older age, earlier age of onset and lower extraversion predicted poorest course trajectory.Conclusions. MDD, Dysth and DD did not adequately match empirically derived course trajectories for unipolar depression. For the future classification of unipolar depression, it may be wise to retain the larger, heterogeneous category of unipolar depression, adopting cross-cutting dimensions of severity and duration to further characterize patients.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Course trajectories of unipolar depressive disorders identified by latent class growth analysis

et al. 2011

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“…In simultaneous RBD, the frequency in UP was 9.5 times higher than among controls, and in BP II 14.2 times higher in the Zurich study (98). Moreover, 38.5% of the individuals with BP II and RBD had attempted suicide, but only 16% of them without RBD.…”

Section: Suicide and Attempted Suicide In Bp IImentioning

confidence: 69%

“…The brief episodes with depressive symptoms usually last for 1Á/14 days (typically 1Á/4 days) and recur at least once per month (98, 131Á/135). RBD has the same character in UP and BP II (98), but is observed somewhat more often in BP II (nearly half of the cases) (98). The occurrence of RBD involves a more severe clinical course with, for example, an early illness debut, high comorbidity with anxiety disorders, greater impulsivity and a heightened frequency of attempted suicide.…”

Section: Other Characteristics Of Bp IImentioning

confidence: 99%

Bipolar II and the bipolar spectrum

Skeppar

Adolfsson²

2006

Nordic Journal of Psychiatry

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In studies made in the last decade, patients consulting doctors because of depression and anxiety have very often turned out to suffer from bipolar type II and similar conditions with alternating depression and hypomania/mania (the bipolar spectrum disorders - BP). Specifically, about every second patient seeking consultation because of depression has been shown to suffer from BP, mainly bipolar type II. BP is often concealed by other psychiatric conditions, e.g. recurrent depression, psychosis, anxiety, addiction, personality disorder, attention-deficit hyperactivity disorder and eating disorder. BP shows strong heredity. Relatives of patients with BP also have a high frequency of the psychiatric conditions just mentioned. Conversion ("switching") from recurrent unipolar depressions (recurrent UP) to BP is common in very long longitudinal studies (over decades). Mood-stabilizing medicines are recommended to a great extent in the treatment of BP, since anti-depressive medicines are often not effective and involve a substantial risk of inducing mood swings. Particularly in the long-term pharmacological treatment of depression in BP anti-depressive medicines may worsen the condition, e.g. inducing a symptom triad of dysphoria, irritability and insomnia: ACID (antidepressant-associated chronic irritable dysphoria).

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The history of bipolar disorders

Marneros

2009

Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy

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Recurrent brief depression as an indicator of severe mood disorders

Cited by 4 publications

References 35 publications

Course trajectories of unipolar depressive disorders identified by latent class growth analysis

Course trajectories of unipolar depressive disorders identified by latent class growth analysis

Bipolar II and the bipolar spectrum

The history of bipolar disorders

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