Recurrent Bilateral Inflammatory Idiopathic Optic Neuropathy Treated with Mycophenolate Mofetil: Clinical and Radiological Course

Benito, Luisa; Muñoz, L; Martínez, M. Luisa; Cortés, Carlos; Andrés, Clara de

doi:10.1080/01658100500218053

Cited by 3 publications

(13 citation statements)

References 16 publications

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“…Finally Google Scholar was used to trace citations of the original description of CRION [1]. This combined search strategy revealed 22 publications [1,4,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. Subsequently, corresponding authors were contacted by email in an attempt to complete the published data.…”

Section: Methodsmentioning

confidence: 99%

“…Bilateral visual loss either simultaneous or sequential has been observed in 36 patients (59%) [1, 4, 15, 19, 21, 24-27, 29, 34]. Not in all cases the time lag of visual loss between the eyes were noted, but true simultaneous loss of vision was present in 8 cases [1,15,24,26,32]. In 12 cases visual loss was only on the left [4, 16-18, 26, 27] and in 11 cases only on the right [4,20,22,23,26,27].…”

Section: Semiologymentioning

confidence: 99%

“…Visual loss in the affected eye was severe in most cases. Summary statistics were performed on the published visual acuity (VA) at presentation using the decimal notation [1,4,15,16,18,[20][21][22][23][24][25][26][27]34]. The median VA in the affected eye was 0.02 (IQR 0-0.25).…”

Section: Semiologymentioning

confidence: 99%

“…Pain. Pain at onset was present in 43 cases [1, 4, 16, 17, 19-23, 32, 34], absent on direct questioning in only 3 cases [1,15,21] and not reported in the remaining patients. Absence of pain occurs in a small proportion of patients with CRION.…”

Section: Semiologymentioning

confidence: 99%

“…Chronicity. The average published follow-up time was 56±54 months (4.6 years) with a median of 36 months (3 years) and a range of 4 to 204 months [1,4,15,17,[19][20][21][22][23][24][25][26][27][28]. The heterogeneity of these data severely limits any estimate of long-term chronicity of CRION.…”

Section: Semiologymentioning

confidence: 99%

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Chronic relapsing inflammatory optic neuropathy: a systematic review of 122 cases reported

2013

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Chronic relapsing inflammatory optic neuropathy (CRION) is an entity that was described in 2003. Early recognition of patients suffering from CRION is relevant because of the associated risk for blindness if treated inappropriately. It seems timely to have a clinical review on this recently defined entity. A systematic literature review, irrespective of language, retrieved 22 case series and single reports describing 122 patients with CRION between 2003 and 2013. We review the epidemiology, diagnostic workup, differential diagnosis, and treatment (acute, intermediate, and long term) in view of the collective data. These data suggest that CRION is a distinct nosological entity, which is seronegative for anti-aquaporin four auto-antibodies and recognized by and managed through its dependency on immuno-suppression. Revised diagnostic criteria are proposed in light of the data compromising a critical discussion of relevant limitations.

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Section: Methodsmentioning

confidence: 99%

Section: Semiologymentioning

confidence: 99%

Section: Semiologymentioning

confidence: 99%

Section: Semiologymentioning

confidence: 99%

Section: Semiologymentioning

confidence: 99%

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Chronic relapsing inflammatory optic neuropathy: a systematic review of 122 cases reported

2013

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Chronic relapsing inflammatory optic neuropathy: description of two clinical cases

Nehrych

Kopchak

Kyryliuk

2020

AML

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Aim. To study the features of the clinical course, diagnosis and treatment of chronic relapsing inflammatory optic neuropathy based on clinical cases. Materials and Methods. Clinical cases of chronic relapsing inflammatory optic neuropathy in two men are presented. The patients underwent neurological and ophthalmological examination, laboratory blood tests, testing of cerebrospinal fluid, magnetic resonance imaging of the brain and spinal cord, perimetry, ophtalmoscopy, optical coherence tomography, ultrasound examination of internal organs and of the branches of the aortic arch, and chest radiography. Results and Discussion. Two cases of chronic relapsing inflammatory optic neuropathy were described in two men aged 44 and 22 years. Episodes of recurrent optic neuritis, both unilateral and bilateral, were observed in patients; their vision improved after corticosteroid therapy. No etiological factors or comorbidities capable of causing the condition were identified. The older patient had 8 attacks of recurrent optic neuritis, with complete recovery of vision after therapy in seven cases, and partial recovery after the last relapse . The 22-year-old patient endured 5 episodes without complete recovery of vision after treatment. Based on the diagnostic criteria of chronic recurrent inflammatory optic neuropathy, this diagnosis was suspected in the patients. Conclusions. Chronic relapsing inflammatory optic neuropathy is a rare pathology whose clinical manifestations must meet diagnostic criteria. Patients with recurrent optic neuritis are to be well examined, in order to make a correct diagnosis and prescribe adequate therapy. Clinical manifestations of chronic relapsing inflammatory optic neuropathy tend to regress and stabilize against a background of immunosuppressive therapy. Keywords: chronic relapsing inflammatory optic neuropathy, clinical cases

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Сhronic relapsing inflammatory optic neuropathy: diagnostic strategies and treatment (literature review)

Nehrych,

Kopchak,

Kyryliuk

2023

Med. perspekt.

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The article presents a review and analysis of scientific works on the problem of chronic relapsing inflammatory optic neuropathy, its diagnostic criteria and treatment methods. Chronic relapsing inflammatory optic neuropathy, first described in 2003, is an autoimmune inflammatory disease of the optic nerve of unknown etiology, accompanied by frequent painful episodes of optic neuritis, with a clear response to steroid therapy and relapses after its withdrawal. An analysis of foreign works published in the E-Library, CrossRef, PubMed, Web of Science, Scopus databases was carried out in order to systematize data on the etiology, pathogenesis, clinical manifestations, diagnostic criteria, differential diagnosis and treatment of this pathological condition. It has been established that chronic recurrent inflammatory optic neuropathy is a rare, recurrent, corticosteroid-dependent optic neuropathy in which there is no other neurological deficit, no etiological factor is identified and it is a diagnosis of exclusion. It is important to identify such patients because the appointment of appropriate immunosuppressive therapy causes remission of the disease.

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Recurrent Bilateral Inflammatory Idiopathic Optic Neuropathy Treated with Mycophenolate Mofetil: Clinical and Radiological Course

Cited by 3 publications

References 16 publications

Chronic relapsing inflammatory optic neuropathy: a systematic review of 122 cases reported

Chronic relapsing inflammatory optic neuropathy: a systematic review of 122 cases reported

Chronic relapsing inflammatory optic neuropathy: description of two clinical cases

Сhronic relapsing inflammatory optic neuropathy: diagnostic strategies and treatment (literature review)

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