Recurrent Bacterial Meningitis due to Genetic Deficiencies of Terminal Complement Components (C5 and C6)

Haeney, M R; Ball, A. P.; Thompson, R. A.

doi:10.1016/s0171-2985(80)80048-9

Cited by 22 publications

(14 citation statements)

References 15 publications

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“…Four patients had had previous episodes of bacterial meningitis, two in the pneumococcal group and one each in the meningococcal and culture negative groups. The previous episodes in both of the latter patients were culture negative and both patients were found to have a familial complement deficiency (Haeney et al 1980). Contact with other cases of bacterial meningitis was recorded in only three patients, two with meningococcal and one with culture negative meningitis accompanied by a florid petechial rash.…”

Section: Resultsmentioning

confidence: 89%

Bacterial meningitis – ten years experience

Davey¹,

Cruikshank²,

McManus

et al. 1982

J. Hyg.

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SummaryBetween January 1968 and December 1977, 635 cases of acute bacterial meningitis were admitted to hospitals in the Birmingham Area Health Authority. The epidemiology of these cases was analysed and compared with the 270 cases which were admitted to the regional infectious diseases unit at East Birmingham Hospital (E.B.H.). In children and young adults the meningococcus was the commonest causative organism while over the age of 25 pneumococcal meningitis predominated. AlthoughHaemophilus influenzaewas the second commonest infecting organism it was a rare cause of meningitis in school children and adults, only four cases presenting in these age groups in the Birmingham Area.A detailed analysis was made of the symptoms, signs, laboratory investigations and clinical course of the 270 cases treated at E.B.H.The mortality in the patients with pneumococcal meningitis was 30%. In the meningococcal group it was 3·5% and in the haemophilus groups 7·7%.An analysis of the various treatment regimes employed in the 270 E.B.H. patients supports the view that a single antibiotic is sufficient for the therapy of most forms of bacterial meningitis. Intrathecal antibiotic administration is unnecessary in pyogenic meningitis caused by meningococci, pneumococci orH. influenzae.

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Section: Resultsmentioning

confidence: 89%

Bacterial meningitis – ten years experience

Davey¹,

Cruikshank²,

McManus

et al. 1982

J. Hyg.

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“…Purulent CSF appears to lack significant bactericidal or opsonic activity (7,8,10). Complement deficiencies predispose to recurrent bouts of meningitis (38,39), and complement components are essential for the control of experimental pneumococcal infections in noncentral nervous system locales as well (40,41). These relative deficiencies permit the extracellular pneumococci to continue multiplying within the CSF and strongly suggest the need for bactericidal antibiotics for cure.…”

Section: Discussionmentioning

confidence: 99%

Bactericidal versus Bacteriostatic Antibiotic Therapy of Experimental Pneumococcal Meningitis in Rabbits

Scheld¹,

Sande²

1983

J. Clin. Invest.

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A B S T R A C T A rabbit model of pneumococcal meningitis was used to examine the importance of bactericidal vs. bacteriostatic antimicrobial agents in the therapy of meningitis. 112 animals were infected with one of two strains of type III Streptococcus pneumoniae. Both strains were exquisitely sensitive to ampicillin, minimum inhibitory concentration (MIC)/ minimum bactericidal concentration (MBC) <0.125 ug/ml. The activity of chloramphenicol against the two strains varied: strain1-MIC 2 ug/ml, MBC 16 /Ag/ml; strain2-MIC 1 ,g/ml, MBC 2 ,g/ml. Animals were treated with either ampicillin or chloramphenicol in dosages that achieved a peak bactericidal effect in cerebrospinal fluid (CSF) for ampicillin against both strains. Two different dosages were used for chloramphenicol. The first dosage achieved a peak CSF concentration of 4.4±1.1 gg/ml that produced a bacteriostatic effect against strainI and bactericidal effect against strain2. The second dosage achieved a bactericidal effect against both strains (mean peak CSF concentration 30.0 Ag/ml). All

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“…Bei den dabei isolierten Erregern handelt es sich um ein Spektrum grampositiver wie gramnegativer Erreger, in dem Meningokokken vergleichsweise selten vertreten sind. Rezidivierende Meningokokkenmeningitiden sind vielmehr verd/ichtig auf einen angeborenen oder erworbenen Mangel der terminalen Komplementfaktoren C5 bis C8 [5,6,7,9,10,12,15,16,17,18,21,23,24,25,26,28,29,30]. Berichte fiber einen heridit/iren C8-Mangel finden sich sehr selten in der Literatur [7,24,25].…”

Section: Abstract: Complement System -C8-deficiency -Meningococcal Munclassified

“…Bisher war man davon ausgegangen, dab abgesehen yon Neisserien sonstige gramnegative oder grampositive Bakterien bereits durch eine intakte Phagozytose abgewehrt werden k6nnen und dab Patienten mit einem Defekt der terminalen Komplementkomponenten nicht geh/iuft an Infektionen mit diesen Erregern erkranken. Eine St6-rung der Antik6rperproduktion soll bei einem Mangel der terminalen Komplementdefekte nicht vorliegen [9,10,23,29]. Bei unserem Patienten fand sich 1984 und 1985 eine leichte Erniedrigung der Immunglobuline im IgG-Bereich bei normalem IgA-und normalem IgM-Spiegel.…”

Section: Diskussionunclassified

Rezidivierende Meningitis bei familiärem Mangel der achten Komponente des Komplementsystems

et al. 1987

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An 18-year-old man suffered from recurrent bacterial meningitis. Investigation of the complement system revealed deficiency of the 8th complement component (C8) in the patient and his sister. Genetic defects of the terminal complement components C5 to C8 predispose to Neisseria infections, probably due to a lack in bacteriolytic activity. It is to be noted that 1 year ago the patient had been hospitalized for a culture-proved pneumococcal meningitis.

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Recurrent Bacterial Meningitis due to Genetic Deficiencies of Terminal Complement Components (C5 and C6)

Cited by 22 publications

References 15 publications

Bacterial meningitis – ten years experience

Bacterial meningitis – ten years experience

Bactericidal versus Bacteriostatic Antibiotic Therapy of Experimental Pneumococcal Meningitis in Rabbits

Rezidivierende Meningitis bei familiärem Mangel der achten Komponente des Komplementsystems

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