RECURRENT ARTERIAL THROMBOSIS IN A CHILD: Primary Antiphospholipid Antibody Syndrome

Abstract

Antiphospholipid antibody syndrome (APS) is characterized by the association of recurrent arterial or venous thrombosis or recurrent fetal wastage and the presence of circulating antiphospholipid antibodies, detected as anticardiolipin antibodies or lupus anticoagulant. The authors report an 8-year-old girl, who presented with central retinal artery occlusion and live do reticularis and was diagnosed as APS. Despite the proper anticoagulant treatment she had several cerebral ischemic events and died 29 months after the diagnosis. A larger number of pediatric case investigations will be required for better understanding and treating this rare thrombotic disorder.

Factor VIII levels in children with thrombosis

“…However, the reports on the pediatric TE disease have emerged in recent publications. 4,[14][15][16][17] In order to elucidate the causes of thrombosis, much effort has been made and the authors have focused on a number of acquired and congenital prothrombotic abnormalities. Of these, elevated plasma levels of FVIII ( ≥ 150 IU/dL) have been shown to be associated with both venous and arterial thrombosis in several studies.…”

Effect of Factor VIIIc Levels in Pediatric Stroke Patients

“…Much effort has been made to elucidate the causes of thrombosis, and authors have focused on a number of acquired and congenital prothrombotic abnormalities [24,25]. Of these, elevated plasma levels of factor VIII (>150 IU/dL) have been shown to be associated with both venous and arterial thrombosis in several studies [15][16][17][18][19]. Mercuri et al evaluated the occurrence of prothrombotic disorders in 24 infants with neonatal stroke and documented association of prothrombotic disorders.…”

Sequential Central Retinal Vein and Ophthalmic Artery Occlusions in a Pediatric Case of Primary Antiphospholipid Syndrome

“…Previous reports have described retinal arteriolar occlusions in pediatric APS. 4,5 Hartnett et al 6 described a case of retinal venous thrombosis with subsequent neovascularization in a 6-year-old patient with primary APS. Consecutive CRVO and ophthalmic artery occlusion have been described in a 60-year-old patient with primary APS.…”