Recurrent arterial embolization from a metastatic germ cell tumor invading the left atrium

Ischemic neuromyopathy due to peripheral arterial embolization of an adenocarcinoma in a cat

“…In human patients, most cases of tumor embolism involve atrial myxomas, which are rare, but frequently embolize (Durgut et al 2002). Remaining cases of tumor embolism are usually associated with pulmonary neoplasia, as was likely in the cat in this report (Starr et al 1981, Singh et al 2000, Xiromeritis et al 2000). A recent retrospective study of 104 cases of tumor embolism in humans found that nearly 90% were associated with lung tumors (44% primary and 32% secondary) and 13% were associated with primary aortic tumors (Xiromeritis et al 2000).…”

“…mbolization of a malignant tumor in a peripheral artery is rare in human beings and poorly documented in animals. Most human cases are associated with primary or secondary lung cancer, following tumor invasion of the pulmonary vein (Starr et al 1981, Singh et al 2000, Xiromeritis et al 2000. In cats, almost all cases of ischemic neuromyopathy result from arterial embolization of a fragment of an intracardiac thrombus, formed as a consequence of underlying cardiac disease (Laste and Harpster 1995).…”

“…Tumor cells were admixed with thrombi in other arterial sections, and within skeletal muscle, there were extensive areas of acute coagulation necrosis (hematoxylin and eosin stain). Singh et al 2000, Xiromeritis et al 2000. A recent retrospective study of 104 cases of tumor embolism in humans found that nearly 90% were associated with lung tumors (44% primary and 32% secondary) and 13% were associated with primary aortic tumors (Xiromeritis et al 2000).…”

Recurrent Peripheral Arterial Embolism from Metastatic Lung Choriocarcinoma

“…6 Peripheral arterial embolism in the presence of lung metastases has also been associated with melanoma, 7 chondrosarcoma, 8 and germ-cell tumor. 9 Furthermore, peripheral arterial embolism has been reported in patients with primary sarcoma of the aorta [10][11][12] and in another patient with metastatic carcinoma to the thoracic aorta. 13 If these patients and our patient were incorporated into the summary developed by Xiromertis et al, 2 we would count at least 115 patients with peripheral arterial tumor embolism, 49 with primary lung cancer, 37 with tumor metastasis into the lungs, and 18 with aortic tumor.…”

Metastatic testicular germ cell tumor with left atrial metastasis via the right pulmonary vein

“…Most common causes of cardiac metastasis in order are lung, breast, and ovarian malignancy. 1 Recognition of cardiac involvement is imperative as complications including stroke 2 , acute limb ischemia 3 and pulmonary venous obstruction 4 may occur.…”