Recurrent Aphthous Stomatitis - A Review

Sankari, S. Leena; Masthan, K. M. K.; Babu, N. Aravindha; Priyadharsini, C

doi:10.13005/bpj/381

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…Pada varian ini dapat ditemukan banyak ulser (multipel ulser) dibandingkan dengan varian SAR lainnya, berukuran kurang <5 mm dan tersebar di sebagian mukosa mulut. 3,4 Streptococcus sanguinis tergolong jenis bakteri Streptococcus virdans dan termasuk pada tipe alfa hemolitik. Bakteri ini biasanya membentuk koloni di rongga mulut, saluran pencernaan dan alat kelamin wanita.…”

Section: Pendahuluanunclassified

Efek Antibakteri Ekstrak Etanol Kulit Bawang Merah (Allium ascalonicum) terhadap Streptococcus sanguinis

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Setiadhi

Sugiaman

2023

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Recurrent aphthous stomatitis is often found in the community, however, the definite cause is still unknown. One of the predisposing factors is Streptococcus sanguinis. Mostly, the treatment for RAS is symptomatic and supportive with antiseptic mouthwash such as 0.2% chlorhexidine gluconate, albeit, it has some side effects for long-term use. Herbal ingredients such as onion peel is expected to cure RAS at a relatively cheap price and minimum side effects. Onion peel (Allium ascalonicum) contains active compounds such as flavonoids, saponins, phenols, tannins, and alkaloids that are known to have antibacterial activity. This study aimed to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of 96% onion peel ethanol extract on the growth of Streptococcus sanguinis. MIC was measured by broth microdilution using 10% DMSO solvent and seven concentrations of onion peel extract, and 0.2% chlorhexidine gluconate as the positive control. The results showed that 96% ethanol extract onion peel with a concentration of 40% was the minimum inhibitory concentration against Streptococcus sanguinis while the minimum kill concentration was 80%. In conclusion, the onion peel (Allium ascalonicum) ethanolic extract has a minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) on the growth of Streptococcus sanguinis. Keywords: recurrent aphthous stomatitis; Streptococcus sanguinis; ethanol extract of onion peel Abstrak: Stomatitis aftosa rekuren sering dijumpai pada masyarakat namun etiologinya masih belum diketahui. Salah satu faktor predisposisi yaitu Streptococcus sanguinis. Penatalaksanaan penyakit ini umumnya simtomatis dan suportif dengan obat kumur antiseptik seperti klorheksidin glukonat 0,2%, namun obat tersebut memiliki efek samping untuk penggunaan jangka panjang. Pengobatan menggunakan bahan herbal seperti kulit bawang merah umumnya memiliki efek samping yang lebih minimal dan diharapkan dapat menyembuhkan SAR dengan harga relatif murah. Kulit bawang merah (Allium ascalonicum) mengandung senyawa aktif seperti flavonoid, saponin, fenol, tanin, dan alkaloid yang diketahui memiliki aktivitas antibakteri. Penelitian ini bertujuan untuk mengetahui kadar hambat minimum (KHM) dan kadar bunuh minimum (KBM) ekstrak etanol 96% kulit bawang merah terhadap pertumbuhan Streptococcus sanguinis. KHM diukur dengan teknik broth microdilution menggunakan pelarut DMSO 10% dan tujuh konsentrasi ekstrak kulit bawang merah. Klorheksidin glukonat 0,2% sebagai kontrol positif. Hasil penelitian mendapatkan ekstrak etanol 96% kulit bawang merah dengan konsentrasi 40% merupakan KHM terhadap Streptococcus sanguinis sedangkan KBM ialah 80%. Simpulan penelitian ini ialah ekstrak etanol kulit bawang merah (Allium ascalonicum) memiliki Kadar Hambat Minimum dan Kadar Bunuh Minimum terhadap pertumbuhan Streptococcus sanguinis. Kata kunci: stomatitis aftosa rekuren; Streptococcus sanguinis; ekstrak etanol kulit bawang merah

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Section: Pendahuluanunclassified

Efek Antibakteri Ekstrak Etanol Kulit Bawang Merah (Allium ascalonicum) terhadap Streptococcus sanguinis

Sihite

Setiadhi

Sugiaman

2023

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An update on investigations of autoimmune diseases affecting orofacial region

Garlapati

Rallabandi

Shalini

2019

Journal of Immunoassay and Immunochemistry

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Presentation of recurrent aphthous ulcer among patients in a tertiary hospital

Okoh

Ikechukwu²

2019

Afr. J. Oral. Health

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Objectives: To determine the prevalence of recurrent aphthous ulcer and the gender and age distribution of the various subtypes of recurrent aphthous ulcer among patients utilizing dental services in University of Benin Teaching Hospital (UBTH). Methods: A retrospective cross sectional study was carried out in Oral Medicine Clinic, UBTH. Data of patients with recurrent aphthous ulcers were collected and analyzed with IBM SPSS version 21.0 software. The association between age and gender distribution amongst patients was analyzed using Chi squared test. The level of significance was set at P < 0.05. Results: The prevalence of recurrent aphthous ulcer in the study was found to be 7.2%, with 54.5% of cases seen in male patients and 45.5% in female. Most of the patients (n=9, 41.0%) were within the 21-30 years age group. Eleven (50.0%) cases of recurrent aphthous ulcer were found to be of the minor subtype with more female preponderance (27.4%), while 8(36.4%) had the hepertiform subtype with equal gender distribution and the least (13.6%) was the major subtype found only in male patients. Conclusion: The study revealed an overall prevalence of 7.2% of recurrent aphthous ulcers with higher occurrence among males. Most of the patients were in the third decade of life. The most common subtype of recurrent aphthous ulcer was the minor type.

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Recurrent Aphthous Stomatitis - A Review

Cited by 3 publications

References 18 publications

Efek Antibakteri Ekstrak Etanol Kulit Bawang Merah (Allium ascalonicum) terhadap Streptococcus sanguinis

Efek Antibakteri Ekstrak Etanol Kulit Bawang Merah (Allium ascalonicum) terhadap Streptococcus sanguinis

An update on investigations of autoimmune diseases affecting orofacial region

Presentation of recurrent aphthous ulcer among patients in a tertiary hospital

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