Recurrent anti-GQ1b IgG antibody syndrome showing different phenotypes in different periods

Abstract

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Acute Ophthalmoparesis Associated With Anti-GM1, Anti-GD1a, and Anti-GD1b Antibodies After Enterovirus Infection in a 6-Year-Old Girl

“…It is generally recognized that there is a link between acute ophthalmoparesis and either anti-GQ1b immunoglobulin G antibody production or the Miller Fisher variant of Guillain-Barré syndrome. 8 It is interesting to note that in humans, GM1, GD1a, and GD1b are present in both dorsal and ventral roots and in peripheral nerves, whereas GQ1b is especially enriched at the nodes of Ranvier of oculomotor nerves. 1 We would suggest that a regional variant of GuillainBarré syndrome developed in our patient; more precisely, an acute axonal motor neuropathy or nerve conduction block of the third right cranial nerve could be suggested.…”

Isolated abducens nerve paresis associated with high titer of anti-asialo-GM1 following Campylobacter jejuni enteritis

“…Sirs: So far only anti-GQ1b antibodies have been identified as a possible pathogenetic factor in acute ophthalmoparesis [2, 3,5,6,8,10]. Here we report one patient with isolated abducens palsy following a Campylobacter jejuni enteritis associated with high titer of anti-asialo-GM1 antibodies, a marginally elevated titer of antiGQ1b-antibodies and a negative titer of GM1 antibodies.…”

Recurrent Miller Fisher Syndrome with Vestibular Involvement

“…Changing phenotypes of MFS have been already reported [7]. The patient never developed drowsiness, respiratory disturbances, or pyramidal signs suggestive of Bickerstaff encephalitis.…”