Recurrent Ameloblastoma: Clinical Manifestation and Disease-Free Survival Rate

Abstract

Objectives. Ameloblastoma is a slow-growing epithelial odontogenic neoplasm of the jaws with a high recurrence rate. The main treatment strategies for this lesion are radical or conservative surgical approaches. The aim of the present study was to analyze clinical presentations, histological types, and treatment strategies of recurrent ameloblastoma and to define its disease-free survival (DFS) rate. Materials and Methods. Twenty-four cases of recurrent ameloblastomas, treated between January 2009 and July 2021, were enrolled in this study. Medical files from each patient, including gender, age, size of the lesion, localization, patient complaints, clinical manifestation, radiographic appearance, histological type, surgical management, and treatment results were reviewed and analyzed retrospectively. Result. Out of 69 operated primary ameloblastomas, the rate of recurrence was 35%. Out of 24 recurrent cases, 21 developed after conservative treatment and 3 after radical treatment. In most cases, recurrences were found in the mandible (n = 20). A unilocular pattern was predominant in radiographic examination (44%). Estimated 3-year DFS was 84.5 ± 4.8%, and the 5-year and 10-year DFS were 73.0 ± 6.3% and 43.9 ± 8.343.9 ± 8.3%, respectively. Conclusion. Results obtained in the present retrospective study proved the necessity of long-term follow-up after both conservative and radical treatment approaches. The DFS median in our study was 8 years (95% CI 6 years–10 years). For recurrent cases, radical resection with histologically free margins after exact MRI determination of the ameloblastoma border within the soft tissues should be considered as the method of choice to avoid secondary recurrence.

Comparison of diagnostic methods for detection of BRAFV600E mutation in ameloblastoma

“…Albeit FFRSS samples were included to account for inadvertent errors that often occur with tissue handling and processing making vital surgical tissue samples unusable for molecular biology techniques. The age and gender distribution of our study patients align with established demographic profile of ameloblastoma patients 19,20 . However, majority of the patients were overwhelmingly Afro‐descendants (95%).…”

“…The age and gender distribution of our study patients align with established demographic profile of ameloblastoma patients. 19,20 However, majority of the patients were overwhelmingly Afro-descendants (95%). Ameloblastoma is highly prevalent in Africa 15 but there is paucity of information on genetic profile of ameloblastomas from Afro-centric patients.…”

Hemimaxillectomy defect reconstruction with a maxillary obturator prosthesis using a 3D-model stereolithography: A case report

“…Ameloblastoma should generally be continuously monitored because recurrences can occur up to 15 years after primary therapy [ 18 ]. Due to anatomical relationships, ameloblastomas in the maxilla are typically more challenging to manage and treat than those in the mandible.…”

Ameloblastoma Na Infância

“…No presente caso clínico, o diagnóstico de ameloblastoma convencional do tipo plexiforme despertou o alerta para alto índice (55-90%) de recidiva após a intervenção cirúrgica menos mutilante do ameloblastoma primário 2,4 . De acordo com a literatura, a variante convencional é a de maior prevalência, bem como possui alto potencial infiltrativo nas trabéculas ósseas 2,10,11 .…”

“…De acordo com a literatura, a variante convencional é a de maior prevalência, bem como possui alto potencial infiltrativo nas trabéculas ósseas 2,10,11 . Um estudo evidenciou que nos casos de ameloblastoma sólido, a taxa de recorrência foi maior após tratamento menos mutilante 4 . Este tipo de abordagem é um grande desafio entre os cirurgiões bucomaxilofaciais, já que, independentemente da habilidade técnica do profissional existe um grande potencial de recidiva que pode ocorrer em até 45 anos após a cirurgia de intervenção inicial 14 Neste contexto, pesquisas devem ser conduzidas com vistas a ressaltar a importância da abordagem interdisciplinar no diagnóstico e tratamento de pacientes pediátricos com ameloblastoma a fim de preservar a integridade estrutural, funcional e psicossocial para uma melhor qualidade de vida destas crianças.…”