Recurrent airway obstruction—heaves

Léguillette, Renaud

doi:10.1016/s0749-0739(02)00067-6

Cited by 105 publications

(100 citation statements)

References 82 publications

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“…A number of environmental, immunologic, infectious and genetic factors play an important role in the pathogenesis of equine recurrent airway obstruction (RAO) (Léguillette 2003). However, the immunological basis of this disease is still poorly understood and requires further studies.…”

Section: Introductionmentioning

confidence: 99%

Circulating immune complexes and markers of systemic inflammation in RAO-affected horses

Niedźwiedź¹,

Jaworski²,

Kubiak³

2014

Polish Journal of Veterinary Sciences

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The aim of this study was to investigate the levels of circulating immune complexes (CICs) and concentration of haptoglobin, fibrinogen and C-reactive protein in the serum of horses with recurrent airway obstruction and healthy controls. The study was conducted on a group of 14 adult Polish Konik horses, kept in uniform environmental and living conditions. Horses were divided into two groups: 7 horses were not affected by any respiratory problem (control group) and 7 horses had a history of recurrent airway obstruction (RAO) (study group). A clinical and laboratory evaluation, endoscopic examination and bronchoalveolar lavage (BAL) were performed in all horses. Levels of circulating immune complexes were significantly (p=0.0057) increased in heaves-affected horses compared to healthy controls (median [25 th -75 th percentiles]) (3.96 [3.96 -4.43] vs. 7.46 [5.13 -11.9]). No significant difference was observed in the levels of the examined acute phase proteins between the groups. Moreover, all results were within the reference range established for horses. The results of this study indicate that heaves in horses is associated with the formation and high level of CICs. Haptoglobin, fibrinogen and C-reactive protein failed as markers of early stage systemic inflammation in the course of RAO.

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Section: Introductionmentioning

confidence: 99%

Circulating immune complexes and markers of systemic inflammation in RAO-affected horses

Niedźwiedź¹,

Jaworski²,

Kubiak³

2014

Polish Journal of Veterinary Sciences

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“…However, many owners are oblivious to the early signs of IAD, which might later progress to RAO with its potentially debilitating consequences 2. Still to date, the assumption that horses with IAD are at increased risk of developing RAO remains speculative and has not been appropriately investigated 3, 4, 5. To our knowledge, the present results provide the first scientific basis for this assumption.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Coughing and Nasal Discharge as Early Indicators for An Increased Risk to Develop Equine Recurrent Airway Obstruction (RAO)

Bosshard

Gerber

2014

Veterinary Internal Medicne

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BackgroundIt is often assumed that horses with mild respiratory clinical signs, such as mucous nasal discharge and occasional coughing, have an increased risk of developing recurrent airway obstruction (RAO).HypothesisCompared to horses without any clinical signs of respiratory disease, those with occasional coughing, mucous nasal discharge, or both have an increased risk of developing signs of RAO (frequent coughing, increased breathing effort, exercise intolerance, or a combination of these) as characterized by the Horse Owner Assessed Respiratory Signs Index (HOARSI 1–4).AnimalsTwo half‐sibling families descending from 2 RAO‐affected stallions (n = 65 and n = 47) and an independent replication population of unrelated horses (n = 88).MethodsIn a retrospective cohort study, standardized information on occurrence and frequency of coughing, mucous nasal discharge, poor performance, and abnormal breathing effort—and these factors combined in the HOARSI—as well as management factors were collected at intervals of 1.3–5 years.ResultsCompared to horses without clinical signs of respiratory disease (half‐siblings 7%; unrelated horses 3%), those with mild respiratory signs developed clinical signs of RAO more frequently: half‐siblings with mucous nasal discharge 35% (P < .001, OR: 7.0, sensitivity: 62%, specificity: 81%), with mucous nasal discharge and occasional coughing 43% (P < .001, OR: 9.9, sensitivity: 55%, specificity: 89%); unrelated horses with occasional coughing: 25% (P = .006, OR = 9.7, sensitivity: 75%, specificity: 76%).Conclusions and Clinical importanceOccasional coughing and mucous nasal discharge might represent an increased risk of developing RAO.

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“…Furthermore, older animals that were exposed to A. fumigatus had a higher percentage of neutrophils in the BALF (60% or more), when compared to 2-month-old animals (20%). In horses, animals that are older than 5 years of age are more frequently affected by RAO compared to younger animals, and the prevalence of RAO increases with age (Leguillette 2003). Cöutil and War (2003) suggest that the incidence of RAO increases until the animals reach 7 to 10 years of age.…”

Section: Discussionmentioning

confidence: 99%

“…However, although the immunological aspects of RAO have been extensively studied, the precise sequence of events is not fully understood (Leguillette 2003, Wagner 2009). In addition, these investigations have been hampered by problems with the use of antibodies for the detection of equine IgE (Tahon et al 2009) and the lack of suitable immunological tools.…”

Section: Introductionmentioning

confidence: 99%

Inhalation of Aspergillus fumigatus spores induces airway inflammation in mice in a similar manner as observed in Recurrent Airway Obstruction in horses

et al. 2011

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Recurrent airway obstruction—heaves

Cited by 105 publications

References 82 publications

Circulating immune complexes and markers of systemic inflammation in RAO-affected horses

Circulating immune complexes and markers of systemic inflammation in RAO-affected horses

Evaluation of Coughing and Nasal Discharge as Early Indicators for An Increased Risk to Develop Equine Recurrent Airway Obstruction (RAO)

Inhalation of Aspergillus fumigatus spores induces airway inflammation in mice in a similar manner as observed in Recurrent Airway Obstruction in horses

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