Recurrent Acute Kidney Injury with Severe Loin Pain and Patchy Renal Ischaemia after Anaerobic Exercise without Renal Hypouricaemia in a New Zealand European Male

Abstract

Acute kidney injury with severe loin pain and patchy renal ischaemia after anaerobic exercise (ALPE) is a rare clinical syndrome. ALPE has predominantly been described in Japanese and Korean populations to date. Many cases and most recurrent examples are associated with renal hypouricaemia. We describe a 28-year-old New Zealand European male without renal hypouricaemia who developed recurrent ALPE whilst performing elite-level sport. Avoiding elite-level anaerobic exercise was successful at preventing further episodes. This report confirms the first known case of ALPE in a New Zealand European male and raises the possibility that ALPE is an under-recognized condition. Long-term outcomes of recurrent ALPE remain unclear, and preventative strategies should be implemented to preserve renal function. Avoiding intense anaerobic exercise is an effective preventative strategy.

Effect of high-altitude hypoxia environment on uric acid excretion, Desmin protein level in podocytes, and Na+-K+- ATPase activity

“…The low oxygen content in the plateau environment has a series of effects on the body's organs and tissues, including changes in blood biochemistry, rheology, and blood gas (33). The kidney, as an organ to maintain the stability of the internal environment of the body, will be damaged in the hypoxia environment, resulting in pathological changes (34). The kidney plays a key role in adapting to altitude sickness syndrome (high-altitude cerebral edema and high-altitude pulmonary edema) by regulating body fluid, electrolyte, and acid-base homeostasis (35).…”