Recurrent abdominal liposarcoma: Analysis of 19 cases and prognostic factors

Lu, Wei

doi:10.3748/wjg.v19.i25.4045

Cited by 8 publications

(31 citation statements)

References 33 publications

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“…18 In fact, the group of patients with liposarcoma could be divided into well-differentiated, undifferentiated, myxoid and rounded cells. Lu et al 19 showed that well-differentiated and myxoid liposarcoma patients have more prolonged survival rates than the undifferentiated variants. In our series, non-liposarcoma histology was one of the independent variables associated with worse OS and with a shorter recurrence-free period.…”

Section: Discussionmentioning

confidence: 98%

Oncology outcomes in Retroperitoneal sarcomas: Prognostic factors in a Retrospective Cohort study

García-Ortega

Villa-Zepeda

Saíd

et al. 2016

International Journal of Surgery

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Section: Discussionmentioning

confidence: 98%

Oncology outcomes in Retroperitoneal sarcomas: Prognostic factors in a Retrospective Cohort study

García-Ortega

Villa-Zepeda

Saíd

et al. 2016

International Journal of Surgery

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“…Among high-grade dedifferentiation, they also demonstrated UPS most frequently. [13,15] Homologous dedifferentiation is the terminology proposed by the WHO, in 2013 classification, for tumors showing features of both WDLPS and PLS. [5] Earlier, these were classified as mixed liposarcomas.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Dedifferentiated Liposarcomas Emphasizing the Diagnostic Dilemmas

Lali

Kini

Chakraborti

et al. 2020

Indian Journal of Medical and Paediatric Oncology

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Introduction: Dedifferentiated liposarcoma (DDLPS) is defined as a progression of well-differentiated liposarcoma (WDLPS) to another nonlipogenic sarcoma. Since a variety of heterologous sarcomas can be encountered in dedifferentiation, clinical dilemmas arise. The present study analyzed the role of clinicopathologic and immunohistochemical (IHC) features in the diagnosis of DDLPS and its differentiation from mimics. Materials and Methods: A retrospective and prospective study was conducted wherein all cases of liposarcoma from 2012 to 2017 were reviewed. DDLPS cases were identified among pleomorphic lesions. Clinical and histopathological details for these cases were retrieved from medical records section and department archives. Histomorphology and immunohistochemistry (MDM2, S100, and Ki-67) were analyzed for these cases. Results: Among 37 cases of liposarcomas reviewed, DDLPS was diagnosed in 12 cases (32.4%). Mean age of the patients was 54.3 years with equal gender distribution (M:F =1:1.2). Two patients had recurrent tumors. Most were retroperitoneal (58.3%) with mean duration of symptoms being 8.7 months. Mean tumor dimension was 17.5 cm. High-grade dedifferentiated component was most common (83.3%) with only one case each (8.3%) of low-grade and homologous dedifferentiation. Undifferentiated pleomorphic sarcoma was the frequent nonlipogenic sarcoma. MDM2 overexpression was detected in 100%, focal S100 positivity seen in 66.6%, and mean Ki-67 labeling index was 24. Conclusion: DDLPS exhibits aggressive clinical behavior. Adequate sampling, correlation to clinical details, demonstration of transition from WDLPS to DDLPS aid in narrowing the differentials. Immunostaining with MDM2 helps in definite categorization and S100 highlights lipoblasts, when they are not easily identifiable. MDM2, CDK4, and p16 IHC panel is recommended in all cases and fluorescence in situ hybridization analysis where IHC is noncontributory.

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“…[4] Retroperitoneal/Abdominal Liposarcoma Liposarcoma is the most common mesenchymal tumor arising in the abdominal cavity, they can affect the retroperitoneum, mesentery, gastrointestinal wall, or even any organ within the abdominal cavity. [22] The most common site is the retroperitoneum, and LS represents about the 50% of all retroperitoneum sarcomas. The can present at any age, but the mean age of presentation is at 56 years, and it affects males and females equally.…”

Section: Head and Neck Liposarcomasmentioning

confidence: 99%

Liposarcoma: A Pictorial and Literature Review

Santoscoy¹,

Castillo²,

Jose³

et al. 2018

J Clin Res Radiol

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According to some clinical trials and epidemiologic studies, WDL is the most common LS (40%), followed by myxoid LS (20%), DDLS, pleomorphic LS (5%), and, last, mixed-type LS. [3,6,8] There are crucial differences among each subtype regarding presentation, treatment, and prognosis. WDL WDL is the most common subtype, representing the 40-50% of all LSs. WDL is a low-grade tumor due to their highly lipomatous content. Histologically, they are composed of variable size mature adipocytes, with scattered lipoblast and large fibrous stroma, and in some cases, they may present sclerosing and inflammatory components.

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Recurrent abdominal liposarcoma: Analysis of 19 cases and prognostic factors

Abstract: Close follow-up should be conducted in patients with RAL. Early re-operation for relapse is preferred and gross resection most likely prolongs the RFI.

Cited by 8 publications

References 33 publications

Oncology outcomes in Retroperitoneal sarcomas: Prognostic factors in a Retrospective Cohort study

Oncology outcomes in Retroperitoneal sarcomas: Prognostic factors in a Retrospective Cohort study

Analysis of Dedifferentiated Liposarcomas Emphasizing the Diagnostic Dilemmas

Liposarcoma: A Pictorial and Literature Review

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