Recurrence Risk of Febrile Seizures in Children

Rajbhandari, Rateena; Shakya, Kiran; Aryal, Umesh Raj

doi:10.3126/jnps.v32i1.5947

Cited by 13 publications

(18 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The above mentioned studies have also shown that the onset of 1 st episode of febrile seizure before 1 year of age is a risk factor for recurrence, similarly significant association was found between the age of onset and recurrence in the present study. But Ojha et al (23) did not find any association between the two.…”

Section: Resultsmentioning

confidence: 89%

Risk Factors for Recurrence of Febrile Seizures in Children Aged Between 6 Months to 5 Years of Age Admitted to Dr. Punjabrao Deshmukh Medical College, Amravati

Rane¹,

Nistane²,

Barabde³

et al. 2015

jemds

View full text Add to dashboard Cite

Febrile seizures (FS) occur in 2% to 5% of all children and are most common convulsive event in children younger than 60 month. Recurrence of FS ranges from 21-43% in different studies and are associated with various risk factors like age of onset of 1 st episode of FS less than 1 year, duration and grade of fever, parental consanguinity, family history of FS and epilepsy, male gender and complex FS as initial seizure. AIMS AND OBJECTIVE: The purpose of this study was to evaluate the risk factors and their association for recurrences of febrile seizures in children aged between 6 months to 5 years of age. MATERIALS & METHODS:The study design was prospective observational study in which 63 children (6 months to 5 years) presenting with the first episode of FS to Dr. Punjabrao Deshmukh Medical College, Amravati between 1 st November 2013 to 31 st October 2014 were enrolled in the study. These subjects were followed up for a period of 1 year from the date of 1 st episode of FS. RESULTS: In present study 46 out of 63 subjects had recurrence of FS. Male: female ratio in the recurrence group was 0.76:1. Family history of FS and epilepsy was present in 34.9% and 12.6% respectively. Total 67.34% subjects with simple FS and 92.85% with complex FS had recurrence. 69.69% subjects had FS within 24 hours of onset of fever. Parental consanguinity was found in 14 (22.2%) subjects with p value of 0.013. No association between the number of risk factors and recurrence was found. 22 (34.9%) out of total 63 subjects were on intermittent FS prophylaxis during the febrile illness and 15 subjects still had recurrence of FS and hence no significant association between recurrence of FS and intermittent prophylaxis for FS was seen. CONCLUSION: Parental consanguinity and age less than one year for 1 st episode of FS were the only significant risk factors indentified for the recurrence of FS. Age of onset of 1 st episode of FS less than 1 year, duration of fever, grade of fever, family history of FS and epilepsy, male gender and complex febrile seizure as initial seizure were not found to be significantly associated with recurrence of FS. No significant association between the numbers of risk factors and recurrence of FS was found. Prescribing prophylaxis for FS statistically did not show any benefit in decreasing the frequency nor completely stop the recurrences of FS.

show abstract

Section: Resultsmentioning

confidence: 89%

Risk Factors for Recurrence of Febrile Seizures in Children Aged Between 6 Months to 5 Years of Age Admitted to Dr. Punjabrao Deshmukh Medical College, Amravati

Rane¹,

Nistane²,

Barabde³

et al. 2015

jemds

View full text Add to dashboard Cite

show abstract

“…[35][36][37][38] Male to female ratio was 1.4:1 which reemphasized previous studies that febrile seizure was more frequent in boys than girls. 33,35,36,39 However, this study was hospital based and probable gender bias for health seeking behaviour might also be the limiting factors.…”

Section: Discussionmentioning

confidence: 97%

“…33,34 Similarly, etiology of fever varies in various studies. 33,[35][36][37] Hence this study was conducted with objectives to evaluate demographic, clinical profile and laboratory parameters with an emphasis on recurrence of febrile seizures in children presenting to our teaching hospital. Manual checking and coding of data were undertaken before data entry commenced to clean the data and ensure consistency.…”

mentioning

confidence: 99%

Clinical, epidemiological and laboratory characteristics of children with febrile seizures

Shankar

Mahamud

2020

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Febrile seizure is the most common type of seizure disorder that occurs in children aged 6-60 months. Recurrences are common. This study was conducted to evaluate the epidemiology, clinical profile and laboratory parameters of children presenting with febrile seizure in a teaching hospital.Methods: This was a descriptive retrospective study among children presenting with febrile seizure admitted to KIMS, Bengaluru from March (2018-2019). Children between six months to five years were included in the study while patients with prior episodes of afebrile seizures, abnormal neurodevelopment and not meeting the age criteria were excluded. Patient’s demographic and clinical data were collected from the in-patient records and analysed.Results: Among 60 children with febrile seizures were enrolled in our study with highest prevalence in males (58%) and amongst 13-24 months age group (37%). Majority (20%) presented in the monsoon season (June) and in the morning hours (43%). Simple febrile seizures and complex febrile seizures were observed in 60% and 40% respectively. Majority (73%) who developed first episode of seizure were below 24 months ago with mean age of 18.71±11.50 months. 42% had recurrence and was significantly associated with first episode of febrile seizures at age ≤1 year and family history of seizures. Upper respiratory tract infections were the commonest cause of fever. Anaemia and leucocytosis were seen in 72% and 70% cases respectively.Conclusions: Febrile seizure was observed predominantly in children below two years, simple febrile seizure being the commonest. Recurrence was common and significantly associated with the first episode of febrile seizure at the age one year or below and family history. Majority had anaemia which showed that iron deficiency anaemia could be a risk factor. Leucocytosis was present in most which could be either due to underlying infection or due to the stress of seizure itself.

show abstract

“…URTI were also the commonest cause of fever in other studies [ 23 , 25 , 34 , 35 ]. In tropical regions, malaria was the commonest cause of fever [ 34 , 36 ]. Among 12 children who had diarrhea in this study and were diagnosed with gastroenteritis; 67% (8) had stool rotavirus antigen test positive.…”

Section: Discussionmentioning

confidence: 99%

Profile and clinical characterization of seizures in hospitalized children

Mwipopo¹,

Akhatar²,

Fan³

et al. 2016

Pan Afr Med J

View full text Add to dashboard Cite

IntroductionSeizure is the commonest pediatric neurological disorder, which is frightening to caretakers. The current study aims to determine profile, clinical spectrum and analyze the commonest etiology of seizures in children admitted to a tertiary hospital in Central China.MethodsThis was a hospital based retrospective study carried out in Zhongnan Hospital of Wuhan University, China. Computerized data was collected from January 2012 to May 2015. Variables collected were demographics, clinical presentations and laboratory tests; brain imaging studies, electroencephalography, diagnosis, prognosis, outcome and duration of hospitalization.ResultsA total of 200 patients were admitted with seizures. There were 109 (54.5%) males and 91 (45.5%) females. Among these patients, 193 (96.5%) were aged 1 month to 5 years and 182 (91.0%) presented with seizures and fever. Generalized tonic-clonic seizure was the most common seizure type in 196 (98.0%) children. Febrile seizure was the leading etiology of seizure in 175 (87.5%) children followed by epilepsy in 11 (5.5%) children. There were only 3 (2%) children with central nervous system infections. Abnormal brain images were noted in 10 (20%) out of 50 patients. Among 193 children tested for different infections, 49 (25.4%) had positive results. Viral infections were commonest infections by 49.0%, atypical bacterial 34.7% and 16.3% coinfections.ConclusionSeizure was the commonest neurological condition of children admitted in our hospital, febrile seizures being the commonest etiology. The prognosis and outcomes were good but there were prolonged days of hospitalization. Children with unprovoked seizures require brain-imaging studies for better understanding of seizure etiology.

show abstract

Recurrence Risk of Febrile Seizures in Children

Cited by 13 publications

References 15 publications

Risk Factors for Recurrence of Febrile Seizures in Children Aged Between 6 Months to 5 Years of Age Admitted to Dr. Punjabrao Deshmukh Medical College, Amravati

Risk Factors for Recurrence of Febrile Seizures in Children Aged Between 6 Months to 5 Years of Age Admitted to Dr. Punjabrao Deshmukh Medical College, Amravati

Clinical, epidemiological and laboratory characteristics of children with febrile seizures

Profile and clinical characterization of seizures in hospitalized children

Contact Info

Product

Resources

About