Recurrence risk for psoriasis and psoriatic arthritis within sibships

Myers, Andrea; Kay, LJ; Lynch, Sally Ann; Walker, D. J.

doi:10.1093/rheumatology/keh589

Cited by 74 publications

(48 citation statements)

References 25 publications

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“…The prevalence of psoriasis in FDRs of probands with PsA was also increased compared with the population control. A recent UK study reported the prevalence of PsA in siblings to be 14.3% and that in the general population to be 0.3% 12. The calculated λ S was therefore 47.…”

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confidence: 90%

Familial aggregation of psoriatic arthritis

et al. 2008

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confidence: 90%

Familial aggregation of psoriatic arthritis

et al. 2008

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“…Both conditions are considered to be complex diseases that are influenced by environmental and genetic factors. The genetic liability towards the susceptibility to PsA, determined using the sibling recurrence risk (λ s ), is estimated to be much higher (λ s > 30) than that of PsV (λ s = 8–12) 2–4. These differences are suggestive of additional genetic susceptibility loci for PsA, although it is highly likely that environmental factors also contribute to these differences 5…”

Section: Introductionmentioning

confidence: 99%

Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris

et al. 2011

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ObjectiveThere is great interest in the identification of genetic factors that differentiate psoriatic arthritis (PsA) from psoriasis vulgaris (PsV), as such discoveries could lead to the identification of distinct underlying aetiological pathways. Recent studies identified single nucleotide polymorphisms (SNPs) in the interleukin 13 (IL-13) gene region as risk factors for PsV. Further investigations in one of these studies found the effect to be primarily restricted to PsA, thus suggesting the discovery of a specific genetic risk factor for PsA. Given this intriguing evidence, association to this gene was investigated in large collections of PsA and PsV patients and healthy controls.MethodsTwo SNPs (rs20541 and rs1800925) mapping to the IL-13 gene were genotyped in 1057 PsA and 778 type I PsV patients using the Sequenom genotyping platform. Genotype frequencies were compared to those of 5575 healthy controls. Additional analyses were performed in phenotypic subgroups of PsA (type I or II PsV and in those seronegative for rheumatoid factor).ResultsBoth SNPs were found to be highly associated with susceptibility to PsA (rs1800925 ptrend = 6.1×10−5 OR 1.33, rs20541 ptrend = 8.0×10−4 OR 1.27), but neither SNP was significantly associated with susceptibility to PsV.ConclusionsThis study confirms that the effect of IL-13 risk locus is specific for PsA, thus highlighting a key biological pathway that differentiates PsA from PsV. The identification of markers that differentiate the two diseases raises the possibility in future of allowing screening of PsV patients to identify those at risk of developing PsA.

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“…Moll and Wright4 were the first to report a recurrence risk ratio in first-degree relatives (λ 1 ) of 55, compared with estimates ranging from five to 10 in PsC. Another study from the UK, reported a PsA prevalence of 14.3% among siblings and recurrence risk ratio (λ s ) of 47 5. Our group has found a PsA prevalence of 7.6% among first-degree relatives leading to a λ 1 of 30.4 6.…”

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confidence: 99%