Recurrence rates for patients with early-stage breast cancer treated with IOERT at a community hospital per the ASTRO consensus statement for APBI

A systematic review and meta-analysis of intraoperative electron radiation therapy delivered with a dedicated mobile linac for partial breast irradiation in early breast cancer

“…After eliminating duplicates, 1659 articles remained but 1575 did not meet the selection criteria; 66/84 remaining papers were excluded for not meeting clinical and outcome criteria. Consequently, only 18 articles that were published in the period 2010–2023 were suitable for inclusion in this meta-analysis and systematic review [ [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] ]. Fig.…”

“…et al [ 23 ] 2018 Journal of Cancer Research and therapeutics Retrospective trial −1 1 1 2 Guenzi M. et al [ 7 ] 2018 Frontiers in Oncology Retrospective trial 1 1 1 4 Jacobs DHM et al [ 24 ] 2018 Breast Cancer Research and Treatment Prospective Observational trial 1 1 1 5 Sorrentino L. et al [ 25 ] 2018 Elsevier/The Breast Prospective Observational trial 1 1 1 5 Sawaki M. et al [ 26 ] 2019 Annals of Surgical Oncology Prospective Phase II trial 1 1 1 5 Williams V.L. et al [ 8 ] 2019 Brachiterapy Prospective Phase I-II trial 1 1 1 5 Kawamura M. et al [ 27 ] 2020 Journal of Radiation Research Prospective Phase I-II trial −1 1 1 …”

“…As 9 patients had simultaneous bilateral breast cancer and both were treated with IOeRT, the total number of lesions was 5483. Median age was reported in 8 studies [ 6 , 8 , 13 , 14 , 21 , 23 , 24 , 27 ], ranging from 56 to 68 years (study median 64.5 years). Ten studies [ 6 , 8 , 13 , 14 , 20 , 21 , 23 , 24 , 26 , 27 ] reported lowest and highest ages (median lowest age 50 years, range 33–59; median highest age 82.5 years, range 62–91).…”

“…Some specific concerns have arisen with outcomes after IOeRT. Depending on the patient's characteristics and follow-up, local relapse rates even reached an unexpectedly high 10% or more, according to some reports that were prevalently retrospective, prospective observational or phase II studies [ [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] ]. Other concerns were raised about side effects and cosmetic outcomes.…”

Delivery of Adjuvant Radiation in 5 Days or Less After Lumpectomy for Breast Cancer: A Systematic Review

“…Prospective studies evaluating IORT have shown promising initial outcomes, though many studies are limited by small numbers of patients and/or short follow-up. [112][113][114][115][116][117][118][119][120][121][122][123][124][125] For example, a series of 1000 cancers treated with IORT found a 3-year recurrence rate of 3.9%. 113 The TARGIT-R registry was recently published, and with 5-year follow-up, the rate of local recurrence for those patients undergoing primary IORT was 8%, substantially higher than seen with AWBI or APBI.…”