Recurrence, postponing pregnancy, and termination rates after hyperemesis gravidarum: Follow up of the MOTHER study

Nijsten, Kelly; Dean, Caitlin; Minnen, Loïs M. van der; Bais, Joke; Ris‐Stalpers, Carrie; Eekelen, Rik van; Bremer, Henk A.; Ham, David P. van der; Heidema, Wieteke M.; Huisjes, Anjoke; Kleiverda, Gunilla; Kuppens, Simone; Laar, Judith O E H van; Langenveld, Josje; Made, Flip van der; Papatsonis, Dimitri; Pelinck, M. J.; Pernet, Paula; Rheenen-Flach, Leonie van; Rijnders, Robbert J.P.; Scheepers, Hubertina C.J.; Vogelvang, Tatjana E.; Mol, Ben Willem J.; Roseboom, Tessa J.; Koot, Marjette H.; Grooten, Iris J.; Painter, Rebecca C.

doi:10.1111/aogs.14197

Cited by 17 publications

(22 citation statements)

References 31 publications

(90 reference statements)

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“…Our study groups were small, so the number of patients in subgroups of the most infrequent nausea variables and second degree relatives remained limited. However, studies on HG have been conducted in populations of similar or even smaller sizes 3,6,12 . The history of nausea was self‐reported but assessed by a similar questionnaire in both groups.…”

Section: Discussionmentioning

confidence: 99%

“…Often these symptoms lead to dehydration and weight loss. HG is the most common reason for hospitalization in early pregnancy, 2 and has a major impact on women's health and may even influence family planning in the future 3 . Nevertheless in clinical practice, recognition of HG by healthcare personnel is insufficient, and therefore patients are often underdiagnosed and undertreated.…”

Section: Introductionmentioning

confidence: 99%

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Hyperemesis gravidarum: Associations with personal and family history of nausea

Lindström,

Laitinen,

Nurmi

et al. 2023

Acta Obstet Gynecol Scand

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IntroductionThe pathogenesis and risk factors for hyperemesis gravidarum, excessive nausea and vomiting of pregnancy, are not adequately recognized. In our previous study, we found that women with a personal history of nausea in different situations and a family history of nausea and vomiting of pregnancy (NVP) were more likely to have severe NVP. The present study focuses on these themes in association with hyperemesis gravidarum in a hospital setting.Material and methodsWomen with hyperemesis gravidarum (n = 102) were recruited from among patients hospitalized due to hyperemesis gravidarum in Turku University Hospital, Finland. Our control group (Non‐NVP group, n = 138) consisted of pregnant women with no NVP. Personal history of nausea in different situations was inquired about in relation to “motion sickness”, “seasickness”, “migraine”, “other kind of headache”, “after anesthesia”, “during the use of contraception”, and “other kinds of nausea”. Relatives with NVP were divided into first‐degree (mother and sisters) and second‐degree (more distant) relatives.ResultsIn univariate analysis, a personal history of motion sickness, seasickness, nausea related to migraine, nausea with other headache and nausea in other situations were associated with hyperemesis gravidarum. After adjusting for age, parity, pre‐pregnancy body mass index, marital status, and smoking, motion sickness (adjusted odds ratio [aOR] 5.24, 95% confidence interval [CI] 2.67–10.31, p < 0.0001), seasickness (aOR 4.82, 95% CI 2.32–10.03, p < 0.0001), nausea related to migraine (aOR 3.00, 95% CI 1.58–5.70, p < 0.001), and nausea in other situations (aOR 2.65, 95% CI 1.13–6.20, p = 0.025) remained significant. In multivariable analysis with all history of nausea variables, motion sickness (OR 2.76, 95% CI 1.29–5.89, p = 0.009) and nausea related to migraine (OR 3.10, 95% CI 1.40–6.86, p = 0.005) were associated with hyperemesis gravidarum. Having any affected relative (OR 3.51, 95%CI 1.84–6.73, p = 0.0002), especially a first‐degree relative (OR 3.06, 95% CI 1.62–5.79, p = 0.0006), was also associated with hyperemesis gravidarum. Adjustment did not change the results.ConclusionsWomen with a personal history of nausea or a family history of NVP are more likely to suffer from hyperemesis gravidarum. These results are beneficial to better identify and help women at risk for hyperemesis gravidarum.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hyperemesis gravidarum: Associations with personal and family history of nausea

Lindström,

Laitinen,

Nurmi

et al. 2023

Acta Obstet Gynecol Scand

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“…This is incorrect and their own follow-up study, designed the same way, was defined as "a prospective cohort study." 4 Inaccurate ratings assigned to our studies contribute to bias and may underestimate neurodevelopmental findings. The study should be repeated to address concerning errors and biases before drawing conclusions.…”

mentioning

confidence: 91%

Inaccuracies in “Long-term health outcomes of children born to mothers with hyperemesis gravidarum: a systematic review and meta-analysis”

Fejzo

MacGibbon

Mullin

2022

American Journal of Obstetrics and Gynecology

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“…Nijsten et al 8 focused on the long-term impact of HG after an affected pregnancy with 215 women in the Netherlands. Seventy-three women completed an online follow-up questionnaire.…”

Section: Introductionmentioning

confidence: 99%

Survivors' Experiences of Hyperemesis Gravidarum

Beck

2023

Journal of Infusion Nursing

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Hyperemesis gravidarum can result in life-threatening physical and psychological maternal morbidity, including severe dehydration, weight loss, electrolyte imbalance, depression, and suicidal ideation. The reported prevalence of hyperemesis gravidarum ranges from 0.3% to 3.6%. The purpose of this qualitative study was to investigate what blogs can tell us about women's experiences of hyperemesis gravidarum. Thirty-three blogs written by hyperemesis gravidarum survivors posted on Hyperemesis Australia's website were analyzed using Krippendorff's qualitative content analysis method. Clustering was used and yielded 6 themes: (1) debilitating physical and mental health problems: digging deep to persevere, (2) heartbreaking choices, (3) lack of understanding and dismissed, (4) so much guilt surrounding their unborn infant, (5) it takes a village to support women with hyperemesis gravidarum, and (6) warriors and survivors: giving back. Infusion nurses are in a perfect position to provide support and compassionate care for women who are repeatedly coming to the hospital for rehydration treatment. Infusion nurses can validate women's physical and emotional struggles with hyperemesis gravidarum and help to no longer make women feel stigmatized.

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Recurrence, postponing pregnancy, and termination rates after hyperemesis gravidarum: Follow up of the MOTHER study

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmerc ial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 17 publications

References 31 publications

Hyperemesis gravidarum: Associations with personal and family history of nausea

Hyperemesis gravidarum: Associations with personal and family history of nausea

Inaccuracies in “Long-term health outcomes of children born to mothers with hyperemesis gravidarum: a systematic review and meta-analysis”

Survivors' Experiences of Hyperemesis Gravidarum

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