Recurrence of the Original Liver Disease

Liver biopsy

“…It is often important to make a specific diagnosis in the setting of liver test abnormalities early after transplantation to investigate allograft rejection, preservation or reperfusion injury, drug‐induced liver injury, (usually recurrent) viral infection, or bile duct injury. Liver biopsy is also often helpful in the setting of late allograft dysfunction,69 including to investigate the possibility of recurrence of the original disease 70. Some liver transplant programs perform liver biopsy on a protocol basis after transplantation (e.g., annually), even in those patients with normal liver tests, although compelling evidence to support this approach is lacking.…”