Recurrence of primary extramedullary plasmacytoma in breast both simulating primary breast carcinoma

Kaviani, Ahmad; Djamali-zavareie, Mansoor; Noparast, Maryam; Keyhani‐Rofagha, Sedigheh

doi:10.1186/1477-7819-2-29

Cited by 23 publications

(5 citation statements)

References 24 publications

(7 reference statements)

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“…Like our case, EMP was disseminated progressively in multiples sites: testis, skin, and retroperitoneum and mediastinal plasmacytoma; we found two other cases of recurrence EMP in the upper airway and in the breast [9, 10]. …”

Section: Discussionsupporting

confidence: 70%

Extramedullary plasmocytoma relapsing at differents sites: an unusual presentation

Ahnach¹,

Marouan²,

Rachid³

et al. 2013

Pan Afr Med J

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Extramedullary plasmacytoma (EMP) is an uncommon plasma cell neoplasm results from plasma cell proliferation and consists of monoclonal plasmacytic infiltration, without bone marrow involvement and any other systemic characteristics of multiple myeloma. EMP accounts for 3% of all plasma cell neoplasms and approximately 80% to 90% of EMP involve submucosa of the upper aerodigestive, while scrotal, dermis and retroperitoneal infiltration are very rare. There are no consensus guidelines for treatment, but EMP is highly radiosensitive, surgery may be considered for some sites, but 11 at 30% can progress in multiple myeloma. We report here an exceptional case of recurrent EMP in much localization. It's about a man 72 years old with initially testicular plasmocytoma who generalized the plasmacytic infiltration after 16 months in skin and progressively in mediastinal and retroperitoneal plasmacytoma, without any medullar and bone involvement.

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Section: Discussionsupporting

confidence: 70%

Extramedullary plasmocytoma relapsing at differents sites: an unusual presentation

Ahnach¹,

Marouan²,

Rachid³

et al. 2013

Pan Afr Med J

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“…Clinical presentation, radiographic findings, and biopsy are used in conjunction to come to a definitive diagnosis. While primary plasmacytoma is not a common breast lesion, we report it is a possibility [ 10 , 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Solitary Plasmacytoma of the Breast: A Case of an Uncommon Breast Neoplasm

McCormack

Hamad

2023

Case Reports in Hematology

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Plasmacytoma is a rare cancer that originates from a single plasma cell and is characterized by the abnormal proliferation of monoclonal plasma cells. It is typically localized in a single area of the body, most commonly in the bone or soft tissue. Solitary plasmacytoma can be further classified as either solitary plasmacytoma of bone (SPB) or solitary extramedullary plasmacytoma (SEP or EMP). Diagnosis may be delayed in symptomatically silent plasmacytomas, but early diagnosis and prompt treatment are crucial for the management of this disease. The mean age for patients with plasmacytoma varies depending on the specific type of plasmacytoma, but generally, it is more common in older adults. Soft tissue plasmacytomas are uncommon, and plasmacytomas manifesting within the breast are extremely rare, especially when they are not a manifestation of multiple myeloma (MM). This report presents a case of SEP of the breast in a 79-year-old female patient. This rare disease needs to be studied further in terms of long-term survival and disease progression to MM. By raising awareness and understanding of plasmacytoma, we aim to improve outcomes and quality of life for patients affected by this disease.

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“…Primary breast plasmacytoma usually displays mild clinical behaviour and long patient survival, similar to other plasmacytomas originating from soft tissues [5–6]. The majority of cases can be cured by radiotherapy [7].…”

Section: Resultsmentioning

confidence: 99%

“…It is well known that plasmacytomas are radiosensitive, with success rates of 79%–90% and a 10-year survival rate of 50%–100% [5–12]. Solitary EMPs have better prognosis than solitary bony plasmacytomas and can be cured by local radiotherapy [5–7].…”

Section: Discussionmentioning

confidence: 99%

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ecancermedicalscience

Majadob

Al-Sakkaf²,

Rezk³

et al.

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We present a rare case of a multiple recurrent extramedullary plasmacytoma of the breast and spine that showed aggressive behaviour without bone marrow involvement. A 29-year-old woman initially presented with extramedullary plasmacytoma of the left breast that was treated with radiotherapy. Shortly after, a recurrence appeared in the right breast, spine, and in both breasts, despite treatment with local and systemic therapy.

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Recurrence of primary extramedullary plasmacytoma in breast both simulating primary breast carcinoma

Abstract: Background: Extramedullary myelomas (plasmacytoma) are malignant proliferations of plasma cells in the absence of bone involvement. When they occur in the soft tissue they usually involve the upper respiratory tract and oral cavity. Extramedullary plasmacytomas of breast are uncommon.

Cited by 23 publications

References 24 publications

Extramedullary plasmocytoma relapsing at differents sites: an unusual presentation

Extramedullary plasmocytoma relapsing at differents sites: an unusual presentation

Solitary Plasmacytoma of the Breast: A Case of an Uncommon Breast Neoplasm

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