Recurrence of peptic ulcer in uraemic and non‐uraemic patients after <i>Helicobacter pylori</i> eradication: a 2‐year study

Tseng, Guan Ying; Lin, Hwai Jeng; Fang, C.-T.; Yang, Haw‐Ching; Tseng, Guan-Chin; Wang, P.-C.; Hung, Tzu-Chieh; Deng, Yanyong; Cheng, Yao-Wen; Huang, Chiu‐Ching

doi:10.1111/j.1365-2036.2007.03438.x

Cited by 50 publications

(63 citation statements)

References 26 publications

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“…Our study showed that patients with CKD and a history of UGIB had a 2-fold higher risk of UGIB. In addition, H. pylori infection has been associated with a higher risk of UGIB (23,24), and H. pylori eradication therapy decreases the risk of recurrent UGIB (25). Forty-two (1.4%) patients were receiving H. pylori eradication therapy; this therapy did not significantly affect UGIB risk.…”

Section: Discussionmentioning

confidence: 99%

Upper Gastrointestinal Bleeding in Patients with CKD

Liang

Wang

Kuo

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives Patients with CKD receiving maintenance dialysis are at risk for upper gastrointestinal bleeding. However, the risk of upper gastrointestinal bleeding in patients with early CKD who are not receiving dialysis is unknown. The hypothesis was that their risk of upper gastrointestinal bleeding is negatively linked to renal function. To test this hypothesis, the association between eGFR and risk of upper gastrointestinal bleeding in patients with stages 3-5 CKD who were not receiving dialysis was analyzed. Results In total, 2968 patients with stages 3-5 CKD who were not receiving dialysis were followed for a median of 1.9 years. The incidence of upper gastrointestinal bleeding per 100 patient-years was 3.7 (95% confidence interval, 3.5 to 3.9) in patients with stage 3 CKD, 5.0 (95% confidence interval, 4.8 to 5.3) in patients with stage 4 CKD, and 13.9 (95% confidence interval, 13.1 to 14.8) in patients with stage 5 CKD. Higher eGFR was associated with a lower risk of upper gastrointestinal bleeding (P=0.03), with a subdistribution hazard ratio of 0.93 (95% confidence interval, 0.87 to 0.99) for every 5 ml/min per 1.73 m 2 higher eGFR. A history of upper gastrointestinal bleeding (P,0.001) and lower serum albumin (P=0.004) were independently associated with higher upper gastrointestinal bleeding risk. ConclusionsIn patients with CKD who are not receiving dialysis, lower renal function is associated with higher risk for upper gastrointestinal bleeding. The risk is higher in patients with previous upper gastrointestinal bleeding history and low serum albumin.

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Section: Discussionmentioning

confidence: 99%

Upper Gastrointestinal Bleeding in Patients with CKD

Liang

Wang

Kuo

et al. 2014

Clinical Journal of the American Society of Nephrology

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“…Further study is required to confirm whether hypoalbuminemia patients have a higher risk of developing non-H. pylori and non-NSAID peptic ulcers, as do other comorbidities, such as liver cirrhosis, malignancy, and ESRD [17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Higher Risk of Developing Peptic Ulcer Bleeding in Adult Patients Diagnosed with Hypoalbuminemia

Hu¹,

Huang²,

Chang³

2016

Gen Med (Los Angeles)

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“…Patients with ESRD exhibit a higher incidence of PUD than do patients without renal disease [12] . H. pylori is critical in the development of peptic ulcers [46] .…”

Section: H Pylori Eradication and Recurrent Peptic Ulcers In Patientmentioning

confidence: 99%

“…Studies on H. pylori infections in uremic patients have reported rates varying from 27% to 73.0% [12][13][14][15][16][17][18][19][20] . This variation may have been caused by small sample sizes, nonuniform duration of dialysis, and varying methodologies and enrollment criteria.…”

Section: H Pylori Prevalence Among Patients With End-stage Renal Dismentioning

confidence: 99%

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Helicobacter pylori: Effect of coexisting diseases and update on treatment regimens

Chang¹,

Hu²

2015

WJGPT

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Recurrence of peptic ulcer in uraemic and non‐uraemic patients after Helicobacter pylori eradication: a 2‐year study

Abstract: SUMMARY BackgroundThe role of Helicobacter pylori in the pathogenesis of peptic ulcer disease in patients with uraemia remains unclear.

Cited by 50 publications

References 26 publications

Upper Gastrointestinal Bleeding in Patients with CKD

Upper Gastrointestinal Bleeding in Patients with CKD

Higher Risk of Developing Peptic Ulcer Bleeding in Adult Patients Diagnosed with Hypoalbuminemia

Helicobacter pylori: Effect of coexisting diseases and update on treatment regimens

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