Recurrence of Ocular Surface Squamous Neoplasia Treated With Excisional Biopsy and Cryotherapy

Li, Albert S.; Shih, Carolyn; Rosen, Lisa; Steiner, Anne; Milman, Tatyana; Udell, Ira J.

doi:10.1016/j.ajo.2015.04.027

Cited by 32 publications

(28 citation statements)

References 27 publications

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“…Incidence is estimated to be ~20 cases per 1 million people per year. 9 This review is limited to data obtained from only patients of the Anterior Segment Division of The Ohio State University Havener Eye Institute, which were further refined to include only those whose pathology reports were available for review. Several patients who carried one of the ICD-9 codes used in data collection were excluded if there was no pathology report available, typically because the excision occurred prior to use of the current electronic medical record or was performed at an outside institution.…”

Section: Discussionmentioning

confidence: 99%

“…According to the current information available from the United States Center for Disease Control, in 2014, ~17 per 100 adults in the US currently identified as cigarette smokers. 9 A study with a large population of patients following surgical excision of OSSN lesions with available pathology reports and a more detailed substance use history including the number of pack-years of cigarette smoking, current smoking status, number of weekly alcoholic beverages, and number of years of alcohol use may have stronger statistical power. Smoking and alcohol use have been shown to be risk factors for other head and neck SCCs, so continued investigation into their independent or combined influence on OSSN would further add to the literature.…”

Section: Discussionmentioning

confidence: 99%

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Lack of relationship between cigarette smoking and alcohol use with dysplasia grade in ocular surface squamous neoplasia

Early

Adelson

Miller

et al. 2018

OPTH

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ObjectiveTo evaluate smoking and alcohol use as risk factors for higher-grade dysplasia in a population of patients with histopathologically proven ocular surface squamous neoplasia.Materials and methodsThis is a retrospective chart review of data extracted from a database comprising demographic information and medical diagnosis information based on International Classification of Disease codes. Outcome measures were analyzed using the Wilcoxon two-sided test, a non-parametric t-test.ResultsDatabase review yielded 35 patients with ocular surface squamous neoplasia lesions proven by histopathologic analysis. The mean age was 64.51 years with SD 17.54 years. Patients were 28.57% female and 71.43% male. Nearly all patients were White (88.57%), and 5.71% were African American, 2.86% Hispanic, and 2.86% Other. There was no significant difference in dysplasia grade between smokers and non-smokers (P=0.7044), those who used alcohol vs did not use alcohol (P=0.2470), those who used tobacco and alcohol vs those who did not (P=0.5117), and those who used either tobacco or alcohol vs those who did not (P=0.8259).ConclusionNo statistically significant relationship was found between high-grade dysplasia and cigarette smoking, alcohol use, or both cigarette smoking and alcohol use.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lack of relationship between cigarette smoking and alcohol use with dysplasia grade in ocular surface squamous neoplasia

Early

Adelson

Miller

et al. 2018

OPTH

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“…This is our preferred surgical technique. Much lower local recurrence rates have been reported for cryotherapy at the time of excision, such as 7% at 5 years with cryotherapy verses 39% with excision alone [9,10].…”

Section: How Should Surgery Be Performed?mentioning

confidence: 95%

“…intralesional versus topical interferon-a 2b , mitomycin C strength and regimen) that makes comparing these case series fraught with difficulty. Unsurprisingly, reported recurrence rates vary widely, from 0 to 56% with surgical excision alone [9][10][11][12][13], 0-28% with surgical excision followed by topical interferon-a 2b (IFNa 2b ) [12-20], 10-15% with surgical excision followed by topical 5-fluorouracil [16,21,22] and 0-30% with surgical excision followed by topical mitomycin C (MMC) [23][24][25][26][27][28]. From this potpourri of evidence, the clinician must formulate treatment strategies for a diverse patient population, often with many medical comorbidities.…”

Section: Introductionmentioning

confidence: 99%

Management Issues in Conjunctival Tumours: Ocular Surface Squamous Neoplasia

Cohen

O’Day

2019

Ophthalmol Ther

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Ocular surface squamous neoplasia is the most common tumour of the ocular surface. It is a spectrum of disease from intraepithelial dysplasia to invasive squamous cell carcinoma. Recent years have seen an increase in the use of topical chemotherapeutic agents to treat this condition, often as primary treatment without full-thickness biopsy. This practical approach provides a critical appraisal of the evidence base with the goal being to aid the clinician in the management of these patients.

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“…Treatment of OSSN includes a variety of options and even combinations of therapy, such as excisional biopsy, cryotherapy, or topical chemotherapy [4,5]. Personalizing treatment requires evaluation of not just the medical aspects of the condition but also the social needs of the patient.…”

Section: Introductionmentioning

confidence: 99%

Cost-effective treatment of ocular surface squamous neoplasia for an undocumented and uninsured New York City patient: a case report

Saffra

Emborgo²,

Iacob

et al. 2020

J Med Case Reports

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Background New York City has a heterogeneous population with many undocumented and uninsured immigrants from equatorial areas who have a higher incidence of ocular surface squamous neoplasia. To the best of our knowledge, this is the first documented selection of this cost-effective treatment of ocular surface squamous neoplasia (the use of absolute ethanol along the corneal margin, primary excision, double freeze-thaw cryopexy, and primary conjunctival closure) for an undocumented and uninsured New York City patient. Case presentation A 35-year-old man from Ecuador presented to a New York City emergency department due to worsening discomfort of a long-standing left eye pterygium. A slit-lamp examination of the left eye demonstrated a nasally located conjunctival mass measuring 6 × 8 mm extending onto the cornea (3 mm superiorly and 6 mm inferiorly on the cornea). Histological diagnosis confirmed squamous cell carcinoma in situ arising from the pterygium. Surgical excision with adjunctive absolute alcohol with additive double freeze-thaw cryopexy was performed. Our patient has remained free of tumor recurrence at year 2 postoperative visit. Conclusions Our case highlights the need to choose a cost-effective treatment for ocular surface squamous neoplasia in an at-risk population among undocumented and uninsured patients. Areas in the world with similar types of populations or treatment challenges may need to consider this approach as a primary treatment option.

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Recurrence of Ocular Surface Squamous Neoplasia Treated With Excisional Biopsy and Cryotherapy

Cited by 32 publications

References 27 publications

Lack of relationship between cigarette smoking and alcohol use with dysplasia grade in ocular surface squamous neoplasia

Lack of relationship between cigarette smoking and alcohol use with dysplasia grade in ocular surface squamous neoplasia

Management Issues in Conjunctival Tumours: Ocular Surface Squamous Neoplasia

Cost-effective treatment of ocular surface squamous neoplasia for an undocumented and uninsured New York City patient: a case report

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