Recurrence of non‐alcoholic steatohepatitis and cryptogenic cirrhosis following orthotopic liver transplantation in the context of the metabolic syndrome

Abstract

Higher recurrence of NASH and CC was associated with presence of MS, HTN and insulin use. Recurrence should be further evaluated in larger studies, with special emphasis on management of MS and prevention strategies.

Long-Term Survival with Growth Hormone Replacement after Liver Transplantation of Pediatric Nonalcoholic Steatohepatitis Complicating Acquired Hypopituitarism

“…Although these noninvasive methods can detect hepatic steatosis, but the recurrence of NASH could not be assessed. Metabolic syndrome, including obesity and type 2 diabetes mellitus, plays an essential role in the recurrence of NASH after LT (El Atrache et al 2012). Recurrence of NASH has not been observed in patients with significantly reduced weight after LT (Koneru and Dikdan 2002).…”

Nonalcoholic steatohepatitis in posttransplantation liver: Review article

“…The studies of Contos et al, 9 Ong et al, 10 El Atrache et al, 19 and Dureja et al 20 found advanced fibrosis, greater than grade 3, in about 4% of the samples. Contos et al 9 associate the increased recurrence of NAFLD with the use of corticosteroids.…”

“…The authors observed that patients transplanted due to NASH have an incidence of MetS similar to those transplanted for other reasons, around 50% (Table 3). In the series evaluated by Laish et al 35 and El Atrache et al, 19 the population evaluated consisted exclusively of patients transplanted due to NASH. In the investigation by Seo et al, 40 the population consisted of patients with de novo NASH.…”

“…57 There is no association of NODAT with graft dysfunction and decreased survival. 63 Even though studies evaluating patients with posttransplant NAFLD 8,19,40,45 yield prevalence rates for diabetes similar to those of the general population, there is an investigation by Stepanova et al 64 including over 15,000 transplanted patients, some 3,000 of which transplanted due to NASH, which eventually concluded that the latter have a higher risk of developing DM.…”

“…10,19,21,31 NODAT was observed in 10% to 36% of the population and was related to obesity, positive family history, glucose intolerance prior to transplantation and hepatitis C as the etiology of transplantation, in addition to immunosuppressants, especially calcineurin inhibitors. 53,62 Numerous studies have demonstrated a higher incidence of dyslipidemia and hypertension in posttransplant patients.…”