Recurrence of non‐alcoholic steatohepatitis after liver transplantation in a 13‐yr‐old boy

Jankowska, Irena; Socha, Piotr; Pawłowska, Joanna; Teisseyre, Mikołaj; Gliwicz, Dorota; Czubkowski, Piotr; Kaliciński, Piotr; Cielecka-Kuszyk, Joanna; Socha, Jerzy

doi:10.1111/j.1399-3046.2007.00767.x

Cited by 24 publications

(19 citation statements)

References 14 publications

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“…Both patients had a history of hypothalamic/pituitary dysfunction; in one case associated with hepatopulmonary syndrome. These two cases34 35 extended prior observations of the development of severe liver disease from NAFLD in patients with hypothalamic/pituitary dysfunction 36…”

Section: Discussionsupporting

confidence: 71%

“…It is also intriguing that both cases undergoing liver transplantation in our series developed recurrent NASH, with cirrhotic stage disease in one patient who required re-transplantation. Recurrence of NASH after liver transplantation in children has been documented in two isolated cases,34 35 both male patients of age 13 and 16 years who developed decompensated liver disease from NAFLD. Both patients had a history of hypothalamic/pituitary dysfunction; in one case associated with hepatopulmonary syndrome.…”

Section: Discussionmentioning

confidence: 99%

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The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years

Feldstein

Charatcharoenwitthaya

Treeprasertsuk

et al. 2009

Gut

614

430

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Objectives: The long-term prognosis of non-alcoholic fatty liver disease (NAFLD) in children remains uncertain. We aimed at determining the long-term outcomes and survival of children with NAFLD. Design: Retrospective longitudinal hospital-based cohort study. Patients: Sixty-six children with NAFLD (mean age 13.9 (SD 3.9) years) were followed up for up to 20 years with a total of 409.6 person-years of follow-up.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years

Feldstein

Charatcharoenwitthaya

Treeprasertsuk

et al. 2009

Gut

614

430

View full text Add to dashboard Cite

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“…In one report, 21 patients were diagnosed with NAFLD 6.4 years after the diagnosis of pituitary and hypothalamic dysfunction (Adams et al 2004). Of the 10 patients biopsied, six had cirrhosis, two had simple steatosis, and two had NASH with fibrosis requiring LT. Two other case reports described patients with cirrhosis secondary to NASH with hypopituitarism associated with HPS; both of these patients were diagnosed with recurrent NASH within 6 months after LT (Jonas et al 2005;Jankowska et al 2007). Even with careful monitoring and treatment of endocrine abnormalities, NAFLD and NASH recur in most of these patients after LT, with some of these patients requiring re-transplantation.…”

Section: Discussionmentioning

confidence: 98%

“…This may be owing in part to treatment with metformin, an agent shown effective for pediatric NAFLD and NASH (Schwimmer et al 2005;Jankowska et al 2007). Stable liver function in our patient may also be because of GH replacement therapy.…”

Section: Discussionmentioning

confidence: 99%

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Long-Term Survival with Growth Hormone Replacement after Liver Transplantation of Pediatric Nonalcoholic Steatohepatitis Complicating Acquired Hypopituitarism

Fujio

Kawagishi

Echizenya

et al. 2015

Tohoku J. Exp. Med.

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Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis

et al. 2008

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Transient elastography (TE) has received increasing attention as a means to evaluate disease progression in chronic liver disease patients. In this study, we assessed the value of TE for the prediction of fibrosis stage in a cohort of pediatric patients with nonalcoholic steatohepatitis. Furthermore, TE interobserver agreement was evaluated. TE was performed in 52 consecutive biopsy-proven nonalcoholic steatohepatitis patients (32 males, 20 females, age 13.6 ؎ 2.44 years). The area under the receiver operating characteristic curves for the prediction of "any" (>1), significant (>2), or advanced fibrosis (>3) were 0.977, 0.992, and 1, respectively. Calculation of multilevel likelihood ratios showed that TE values <5, <7, and <9 kPa, suggest the presence of "any" fibrosis, significant fibrosis, and advanced fibrosis, respectively. TE values between 5 and 7 kPa predict a fibrosis stage of 1, but with some degree of uncertainty. TE values between 7 and 9 kPa predict fibrosis stages 1 or 2, but cannot discriminate between these two stages. TE values of at least 9 kPa are associated with the presence of advanced fibrosis. The intraclass correlation coefficient for absolute agreement was 0.961. Conclusion: TE is an accurate and reproducible methodology to identify pediatric subjects without fibrosis or significant fibrosis, or with advanced fibrosis. In patients in which likelihood ratios are not optimal to provide a reliable indication of the disease stage, liver biopsy should be considered when clinically indicated. (HEPATOLOGY 2008;48:442-448.) N onalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome, a cluster of abnormalities related to insulin resistance, which is frequently associated with obesity. Given the strong association of NAFLD with increased body mass index (BMI) and the considerable increase in the prevalence of overweight among children and adolescents, 1 NAFLD represents an emerging clinical problem affecting a substantial proportion of these subjects (2.6%-9.8%), 2-3 especially in the presence of obesity. 4 The high prevalence of NAFLD, and the likelihood of evolution to cirrhosis and its complications warrant increased attention toward this disorder. 5-9 Disease progression depends on the presence of hepatocellular damage, inflammation and fibrogenesis which define a pathological entity called nonalcoholic steatohepatitis (NASH).Currently, histopathological analysis of liver tissue represents the only means to assess fibrosis in NAFLD. 10 In the past decade, major efforts have been directed at identifying noninvasive methods for the assessment of liver fibrosis in different chronic liver diseases (CLD) including NAFLD. 11 These efforts assume a particular relevance in the pediatric setting, where the use of liver biopsy is perceived as bearing higher risks and is less acceptable than in adults.A noninvasive medical device based on transient elastography (TE) (Fibroscan; Echosens, Paris, France) has

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Recurrence of non‐alcoholic steatohepatitis after liver transplantation in a 13‐yr‐old boy

Cited by 24 publications

References 14 publications

The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years

The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years

Long-Term Survival with Growth Hormone Replacement after Liver Transplantation of Pediatric Nonalcoholic Steatohepatitis Complicating Acquired Hypopituitarism

Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis

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