Recurrence of infection and diversity of Helicobacter pylori strains in an adult population in Mexico treated with empirical standard triple therapy.

Cuén, Jaime Alberto Sánchez; Cabrales, Ana Bertha Irineo; Sicairos, Nidia Maribel León; Zamora, Loranda Calderón; Higuera, Luis Monroy; Román, Vicente Adrián Canizalez

doi:10.17235/reed.2017.4994/2017

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…Literature suggests that recurrence rates in developing countries are much higher than those in developed countries (11,12). For example, the annual recurrence rate in Latin America is 11.2% (13), while it is 9.3% in Mexico (14). A study in South Korea reported a recurrence rate of 10.9% following eradication (15), and in Vietnam, the reinfection rate was 23.5% after 11 months of follow-up (16).…”

Section: Discussionmentioning

confidence: 99%

Analysis of Risk Factors for the Recurrence of Helicobacter Pylori Infection in Baoding Children Aged 4 - 16 Years

Teng,

Dong,

Liu

et al. 2024

Iran J Pediatr

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Background: Helicobacter pylori (H. pylori) infection affects over 50% of the world's population and is the primary cause of duodenal and gastric ulcers, as well as gastric cancer. Objectives: To investigate the risk factors for recurrence following successful eradication of H. pylori infection in children aged 4 - 16 years in the Baoding area. Methods: The study included 328 children diagnosed with H. pylori infection at our hospital from January 2021 to June 2022, who had successfully undergone eradication treatment. A questionnaire covering personal history, family history, health status, and family socioeconomic status was administered to the children, coupled with a 1-year follow-up. Recurrence within this period was monitored, along with an analysis of the risk factors for recurrence post-eradication. Results: Out of 328 children with H. pylori infection, 295 (89.9%) were successfully followed up. Among these, 55 (18.6%) tested positive on the 13C-urea breath test and were considered to have recurrent infection (recurrence group), while 240 (81.4%) tested negative and were considered to have no recurrence (non-recurrence group). Univariate chi-square analysis of the questionnaire results indicated that age (P < 0.05), number of eradication treatments (P < 0.05), mother's education level (P < 0.05), place of residence (P < 0.05), family income (P < 0.05), family history of H. pylori infection (P < 0.05), separate meals (P < 0.05), and lunch location (P < 0.05) significantly influenced H. pylori recurrence. Multivariate analysis, which included factors showing significant differences in univariate analysis, was performed using a logistic regression model. This analysis identified multiple treatments (> 2 eradication attempts), residing in rural areas, and low family income as combined risk factors for H. pylori recurrence in children. Conversely, being older than 10 years, eating separate meals, and higher maternal education level emerged as protective factors against recurrence. Conclusions: There is a relatively high rate of H. pylori recurrence among children aged 4 - 16 years in this region, which may be linked to age, number of eradication treatments, dietary and hygiene habits, educational levels of family members, and economic status.

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Section: Discussionmentioning

confidence: 99%

Analysis of Risk Factors for the Recurrence of Helicobacter Pylori Infection in Baoding Children Aged 4 - 16 Years

Teng,

Dong,

Liu

et al. 2024

Iran J Pediatr

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Hydrogen Peroxide-Mediated Oxygen Enrichment Eradicates Helicobacter pylori In Vitro and In Vivo

Dounan

Zhang

Cao

et al. 2020

Antimicrob Agents Chemother

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Helicobacter pylori is an important risk factor for gastric ulcers. However, antibacterial therapies increase the resistance rate and decrease the eradication rate of H. pylori. Inspired by the microaerophilic characteristics of H. pylori, we aimed at effectively establishing an oxygen-enriched environment to eradicate and prevent the recurrence of H. pylori. The effect and the mechanism of an oxygen-enriched environment in eradicating H. pylori and preventing the recurrence were explored in vitro and in vivo. During oral administration and after drug withdrawal, H. pylori counts were evaluated by Giemsa staining in animal cohorts. An oxygen-enriched environment in which H. pylori could not survive was successfully established by adding hydrogen peroxide into several solutions and rabbit gastric juice. Hydrogen peroxide effectively killed H. pylori in Columbia blood agar and special peptone broth. Minimum inhibition concentrations and minimum bactericidal concentrations of hydrogen peroxide were both relatively stable after promotion of resistance for 30 generations, indicating that hydrogen peroxide did not easily promote resistance in H. pylori. In models of Mongolian gerbils and Kunming mice, hydrogen peroxide has been shown to significantly eradicate and effectively prevent the recurrence of H. pylori without toxicity and damage to the gastric mucosa. The mechanism of hydrogen peroxide causing H. pylori death was related to the disruption of bacterial cell membranes. The oxygen-enriched environment achieved by hydrogen peroxide eradicates and prevents the recurrence of H. pylori by damaging bacterial cell membranes. Hydrogen peroxide thus provides an attractive candidate for anti-H. pylori treatment.

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Recurrence of infection and diversity of Helicobacter pylori strains in an adult population in Mexico treated with empirical standard triple therapy.

Cited by 2 publications

References 37 publications

Analysis of Risk Factors for the Recurrence of Helicobacter Pylori Infection in Baoding Children Aged 4 - 16 Years

Analysis of Risk Factors for the Recurrence of Helicobacter Pylori Infection in Baoding Children Aged 4 - 16 Years

Hydrogen Peroxide-Mediated Oxygen Enrichment Eradicates Helicobacter pylori In Vitro and In Vivo

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