Recurrence of <i>Plasmodium falciparum</i> after treatment with quinine and doxycycline in the Amazon basin

Gomes, Margarete do Socorro Mendonça; Vieira, José Luiz Fernandes; Couto, Álvaro Augusto Ribeiro D'Almeida; Couto, Vanja Suely Calvosa D’Almeida; Vieira, Michelle Valeria Dias Ferreira; Pereira, Francis Christian da Silva; Machado, Ricardo Luiz Dantas

doi:10.1111/tmi.12813

Cited by 1 publication

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“…Moreover, the chance of a recrudescence after a second-line treatment of oral quinine plus doxycycline is very low [13]. Reasons for failure with this regimen may include a decrease in the sensitivity or an inadequate exposure to the drug caused by unusual pharmacokinetics in an individual, scarce adherence to the prescribed regimen or poor quality of anti-malarial drugs [14]. In this case, therefore, the concurrence of both pathogen- and host-related factors could have been responsible for the second recrudescence.…”

Section: Discussionmentioning

confidence: 99%

An intricate case of multidrug resistant Plasmodium falciparum isolate imported from Cambodia

Dell’Acqua

Fabrizio

Gennaro

et al. 2017

Malar J

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BackgroundImported cases of multidrug resistant Plasmodium falciparum and treatment failure with artemisinin-based regimens, although rare, have been described also in Western countries and their management is often challenging. This is also due to an inadequate knowledge and implementation of health prevention measures.Case reportA complex case of imported malaria caused by Plasmodium vivax/P. falciparum isolates in a patient who was not taking chemoprophylaxis while he was travelling in Cambodia is reported in this article. After failures of artemisinin-based and both oral and intravenous quinine-based regimens, a multidrug resistant P. falciparum was detected. The patient was successfully treated with atovaquone–proguanil.ConclusionsThis experience highlights the importance of a careful management that should be based not only on the most up-to-date guidelines, but also on the awareness of a rapidly evolving scenario.

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Section: Discussionmentioning

confidence: 99%

An intricate case of multidrug resistant Plasmodium falciparum isolate imported from Cambodia

Dell’Acqua

Fabrizio

Gennaro

et al. 2017

Malar J

View full text Add to dashboard Cite

show abstract

Recurrence of Plasmodium falciparum after treatment with quinine and doxycycline in the Amazon basin

Abstract: There is evidence of a decreased in vivo sensitivity to quinine of P. falciparum strains in the Brazilian Amazon basin.

Cited by 1 publication

References 23 publications

An intricate case of multidrug resistant Plasmodium falciparum isolate imported from Cambodia

An intricate case of multidrug resistant Plasmodium falciparum isolate imported from Cambodia

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