Recurrence of graft steatosis after liver transplantation for cryptogenic cirrhosis in recently commenced liver transplant program

Siriwardana, R. C.; Niriella, Madunil Anuk; Dassanayake, Anuradha S; Liyanage, C.A.H.; Gunetilleke, Bhagya; Silva, Hithanadura Janaka de

doi:10.1007/s12664-016-0653-0

Cited by 12 publications

(5 citation statements)

References 6 publications

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“…A single-center retrospective study involving 696 patients with cirrhosis found only 13 (1.87%) patients had chronic hepatitis B infection [48]. In another study done on 81 patients with cirrhosis who were referred for liver transplantation, none had hepatitis B or C [49]. Even though nationwide data on prevalence of hepatitis C virus (HCV) in Sri Lanka is not available, studies conducted in various specific groups of population have shown a seroprevalence of <1% [46].…”

Section: Discussionmentioning

confidence: 99%

Non-alcoholic fatty liver disease and pregnancy complications among Sri Lankan women: A cross sectional analytical study

et al. 2019

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Background Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of liver disease worldwide and is the hepatic manifestation of metabolic syndrome. Effects of NAFLD on pregnancy is still unclear with few studies showing an association to gestational diabetes and pre-eclampsia. We aimed to describe the association between the NAFLD and pregnancy complications. This is the first study, to our knowledge, in a South Asian population. Method A cross sectional analytical study was done in Teaching Hospital, Ragama, Sri Lanka. Women carrying a singleton pregnancy, admitted for delivery were assessed for NAFLD with liver ultrasound scan. Data were extracted from interviewer administered questionnaire and antenatal and inpatient records. Pregnancy complications and labour outcomes were compared between the women with NAFLD and women without NAFLD (non-NAFLD). Results Out of the 573 women who participated, 18.2% (n = 104) were found to have NAFLD. Out of them, 58 (55.8%), 32(30.8%), and 14(13.5%) had fatty liver grade 1,2 and 3 respectively. Women with NAFLD were 2 times more likely to develop gestational hypertension and pre-eclampsia compared to the women in the non-NAFLD group, after adjusting for BMI, age and Hyperglycaemia in pregnancy [Adjusted OR 2.09, (95% CI 1.07–4.10)]. There was no association between the grade of steatosis and a composite outcome of gestational hypertension and pre-eclampsia, within the NAFLD group. Composite outcome of gestational diabetes mellitus and diabetes in pregnancy diagnosed during pregnancy was a significant complication in the NAFLD group compared to non-NAFLD group in the bivariate analysis (27.2% vs 17.7%; p<0.05), but the significance disappeared after adjusting for confounders. The current study did not demonstrate a significant association between NAFLD with preterm labour, caesarean section rate, low birth weight, and Apgar score of the baby. Conclusion Women with NAFLD had a 2-fold higher risk of developing gestational hypertension and pre-eclampsia during pregnancy compared to women without NAFLD, after controlling for other confounding variables.

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Section: Discussionmentioning

confidence: 99%

Non-alcoholic fatty liver disease and pregnancy complications among Sri Lankan women: A cross sectional analytical study

et al. 2019

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“…Preliminary experience from Sri Lanka shows that NAFLD is one of the main reasons for rejecting potential donors of liver. 17 This is experienced at other liver transplant centers from the region as well. Nonalcoholic steatohepatitis is well recognized to recur in patients who undergo liver transplantation for cryptogenic cirrhosis.…”

Section: Introductionmentioning

confidence: 98%

Nonalcoholic Fatty Liver Disease: Identifying the Disease Burden in Sri Lanka

Dassanayake¹

2018

Euroasian Journal of Hepato-Gastroenterology

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Nonalcoholic fatty liver disease (NAFLD) is becoming one of the most important causes for chronic liver disease and also hepatocellular carcinoma (HCC) in Sri Lanka. This tendency is also recognized worldwide. More than half of the middle-aged and elderly adults in urban Sri Lanka have ultrasonic evidence of NAFLD. The NAFLD is also identified in population from rural areas of Sri Lanka and also in children. Nonalcoholic steatohepatitis (NASH) cirrhosis is the most common cause of referral for liver transplantation in Sri Lankans. The NASH is also the most common cause for rejecting potential donors for liver transplantation in Sri Lanka. Patients who underwent liver transplantation for cryptogenic cirrhosis developed evidence of NASH following liver transplantation. Recent evidence suggests that there is a genetic component to NAFLD. PNPLA3, a single gene polymorphism linked to the short arm of chromosome 22, is associated with the severity of NAFLD. The presence of this genetic polymorphism appears to carry higher risk of patients with NAFLD developing NASH with fibrosis cirrhosis and hepatocellular carcinoma. In a large population-based study from Sri Lanka, there was a tendency to develop NAFLD associated with this genetic polymorphism. In a population-based study, NAFLD was identified as an independent risk factor for development of diabetes. This association is recognized worldwide now. Most patients with HHC in Sri Lanka developed it on a back ground of cryptogenic cirrhosis. At the same time, the prevalence of the markers for hepatitis B and C was rare in Sri Lankan patients with HCC.How to cite this article: Dassanayake AS. Nonalcoholic Fatty Liver Disease: Identifying the Disease Burden in Sri Lanka. Euroasian J Hepato-Gastroenterol 2018;8(1):69-72.

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“…However, they are more likely to die from cardiovascular diseases or sepsis (75). Recurrence of NASH in the graft following liver transplant is not uncommon (76).…”

Section: Liver Transplantationmentioning

confidence: 99%

Non-alcoholic fatty liver disease – 2019

in-chief

2019

Sri Lanka J. Diabetes Endocrinol. Metab.

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Recurrence of graft steatosis after liver transplantation for cryptogenic cirrhosis in recently commenced liver transplant program

Cited by 12 publications

References 6 publications

Non-alcoholic fatty liver disease and pregnancy complications among Sri Lankan women: A cross sectional analytical study

Non-alcoholic fatty liver disease and pregnancy complications among Sri Lankan women: A cross sectional analytical study

Nonalcoholic Fatty Liver Disease: Identifying the Disease Burden in Sri Lanka

Non-alcoholic fatty liver disease – 2019

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