Recurrence of adrenal aldosterone-producing adenoma

Abstract

SummaryConn's syndrome (adrenal aldosteroneproducing adenoma) and bilateral adrenal hyperplasia are the most common causes of primary aldosteronism. The treatment of choice for patients with aldosteroneproducing adenoma is unilateral total adrenalectomy. Recurrence after adequate surgery is exceptional. We present a patient with recurrence of an aldosterone-producing adenoma in the right adrenal gland 9 years after adenomectomy of a aldosterone-producing adenoma in the same adrenal gland. We conclude that adenomectomy is not an adequate therapy for patients with adrenal aldosterone-producing adenoma.

K + Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension

“…APAs virtually always remain benign, without local invasion or distant metastasis (9). Surgical removal ameliorates or cures hypertension in the large majority of patients (10). The mechanisms responsible for neoplasia and cell-autonomous aldosterone production are unknown.…”

Analysis of mRNA expression for steroidogenic enzymes in the remaining adrenal cortices attached to adrenocortical adenomas.

“…This approach would seem to be successful, although the postoperative long-term follow-up is often inadequate (5,7,14). Meanwhile, the recurrence of PA or CS following total or subtotal adrenalectomy has also been reported (3,(15)(16)(17). Therefore, knowledge of what lesions are present in the remaining cortices is essential.…”

The Long-term Effect of Adrenal Arterial Embolization for Unilateral Primary Aldosteronism on Cardiorenovascular Protection, Blood Pressure, and the Endocrinological Profile

“…Shigematsu et al demonstrated multiple, highly active aldosterone production nodules, not only in unilateral adrenal hyperplasia, but also in adjacent tissues of APA (21). Even in the case of surgical treatment, CalvoRomero et al reported a case with recurrence in the ipsilateral adrenal gland after partial unilateral adrenalectomy (22). These findings suggest that patients with TAAE must be carefully followed up.…”