Recurrence of a primary xanthoma of the humerus in a 9-year-old normolipidemic child

Primary intraosseous xanthoma of the frontal bone in a child: illustrative case

“…1 Intraosseous xanthomas, benign expansile lesions characterized histologically by abundant lipid-laden histiocytes, are another possible cause of a calvarial mass, but they almost never occur in children. 2,3 Furthermore, when intraosseous xanthomas are observed in children, these lesions generally impact the appendicular skeleton 4 and arise almost exclusively in the setting of hyperlipidemic disease or another systemic condition that may alter fat metabolism (e.g., diabetes). 2,[5][6][7][8][9][10][11] This type of lesion in the absence of systemic disease, termed a "primary intraosseous xanthoma," is exceptionally rare, especially in the pediatric population.…”