Recurrence-Free Survival in Early and Locally Advanced Large Cell Neuroendocrine Carcinoma of the Lung after Complete Tumor Resection

Altieri, Barbara; Salvia, Anna La; Modica, Roberta; Marciello, Francesca; Mercier, Olaf; Filosso, Pier Luigi; Latour, Bertrand Richard De; Giuffrida, Dario; Campione, Severo; Guggino, Gianluca; Fadel, Élie; Papotti, Mauro; Colao, Annamaria; Scoazec, Jean‐Yves; Baudin, Éric; Faggiano, Antongiulio

doi:10.3390/jpm13020330

Cited by 2 publications

(1 citation statement)

References 34 publications

(131 reference statements)

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“…For thymic malignancies, radical resection is considered part of the multimodal treatment in patients of stage III and even stage IVa with pleural spread [17][18][19]. This treatment principles is also applicable to other rare types of locally advanced thoracic cancers, including mediastinal sarcoma [20], mediastinal teratoma [21], mediastinal large cell neuroendocrine cancer [22], pulmonary blastoma [23], pleomorphic lung cancer [24], and large cell neuroendocrine lung cancer [25], which were all also reported in our series. Regardless of the tumor histology, the extent of invasion of adjacent anatomical structures is the key determinant of surgical di culty.…”

Section: Discussionsupporting

confidence: 61%

Is Extended Resection for Locally Advanced Thoracic Cancer with Cardiopulmonary Bypass Justified?

Hsu,

Chou,

Huang

et al. 2024

Preprint

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Background: Resection of intrathoracic tumor with cardiopulmonary bypass (CPB) remains a relatively under-reported intervention in literature, and its role in managing locally advanced mediastinal and lung cancers is a topic of ongoing debate. Our aim was to review our experience and assess the role of CPB for treatinglocally advanced mediastinal and lung cancers. Methods: Between 2015 and 2020, this study initially included 10 patients with primary locally advanced thoracic malignancies with apparent adjacent cardiovascular invasion demonstrated by thoracic imaging scans. Operation was performed based on a multidisciplinary tumor board consensus. Eventually, 8 patients (3 primary lung cancers and 5 mediastinal cancers) received either salvage or elective resection with CPB; two completed surgery without requiring CPB. Results: Regarding the extent of adjacent structure involvement, 4 patients presented with involvement of the superior vena cava (SVC), 1 involved the right atrium (RA), 2 involved the SVC and RA, and 1 involved the SVC, the origin of main pulmonary artery, and the ascending aorta. Thirty-day mortality occurred in two of three patients receiving salvage surgery due to respiratory insufficiency. With the long-term follow-up, one patient died of recurrence 25 months postoperatively, one survived with recurrence 30 months postoperatively, and four were alive without recurrence for 35, 36, 49, and 107months after operations. Conclusions: In certain patients, particularly for elective surgical candidates rather than salvage resection, CPB allows for extended resection of locally advanced thoracic cancerswith acceptable perioperative safety and survival.

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Section: Discussionsupporting

confidence: 61%

Is Extended Resection for Locally Advanced Thoracic Cancer with Cardiopulmonary Bypass Justified?

Hsu,

Chou,

Huang

et al. 2024

Preprint

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Gender Differences in Lung Neuroendocrine Tumors: A Single-Center Experience

Liccardi,

Colao,

Modica

2024

Neuroendocrinology

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Introduction Gender difference may affect lung neuroendocrine tumors (L-NET) onset, progression and outcomes as emerged in other cancers. This study aims to analyse gender difference in L-NET to identify potential prognostic factors, to improve patient follow-up and therapeutic strategies. Methods Patients (pt) with histologically confirmed L-NEN diagnosis referred to the ENETS CoE of the Endocrinology Unit, Federico II University of Naples, from 2013 to 2023 were retrospectively evaluated. Results Among 48 pt with L-NEN, 38 (79,2%) with sporadic L-NET were enrolled: 22 typical (57,9%) and 16 atypical (42,1%) carcinoids, 22 (57,9%) female and 16 (42,1%) male, mean age at diagnosis 57,3 years (range 16-84). Median follow up was 70,5 months (range 12-305). No statistically difference resulted regardig smoking habit, body mass index (BMI), primary site (left/right and central/peripheral) and histological characteristics, between cohorts. Metastasis at diagnosis were found in 20 pt (52,3%), 10 female (10%%), 10 male (10%) (p:0,20). Progressive disease (PD) was observed in 14 (36,8%) pt, male sex developed PD more frequently 9/14 (64,3%) than female 5 (35,7%), p: 0.05. Male sex seemed to show more frequently bone metastasis without reaching statistically difference, 7male/10 (70%), p: 0.06. Among 9 deaths (23,7%), 7 (77,8%) were men and 7 died for PD, p<0,03. Male had a poorer prognosis than female regarding progression free survival (p: 0,04) and overall survival (p:0,001), also when sub-groups of pt metastatic at diagnosis were compared (p: 0,02 and p:0,02). Conclusions This study showed a worse prognosis in male than female with L-NET, despite similar clinical features, tumour type, stage and treatment, with regard to PFS, OS and metastatic spread. These findings may suggest a closer follow up in men, with potential positive impact on outcomes.

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Recurrence-Free Survival in Early and Locally Advanced Large Cell Neuroendocrine Carcinoma of the Lung after Complete Tumor Resection

Cited by 2 publications

References 34 publications

Is Extended Resection for Locally Advanced Thoracic Cancer with Cardiopulmonary Bypass Justified?

Is Extended Resection for Locally Advanced Thoracic Cancer with Cardiopulmonary Bypass Justified?

Gender Differences in Lung Neuroendocrine Tumors: A Single-Center Experience

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